A noninvasive model to predict liver histology for antiviral therapy decision in chronic hepatitis B with alanine aminotransferase < 2 upper limit of normal [PDF]
, 2021 Shanshan Chen, Haijun Huang, Wei Huang
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Advanced Science, EarlyView.Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan +19 more
wiley +1 more source
Extremely Low Activity of Serum Alanine Aminotransferase Is Associated with Long-Term Overall-Cause Mortality in the Elderly Patients Undergoing Percutaneous Coronary Intervention after Acute Coronary Syndrome [PDF]
, 2023 Doo-Young Kim +4 more
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Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis
Advanced Science, EarlyView.Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu +13 more
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Advanced Science, EarlyView.The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen +8 more
wiley +1 more source
Acute Effects of on Javdar Supplementation on Asparate Aminotransferase(AST) and Alanine Aminotransferase(ALT) after Exhaustive Incremental Exercise in Men’s Handball [PDF]
Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2017 Background: The aim of this study was to investigate the acute effect of supplementation Jadvar on aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzymes after exhaustive incremental exercise in men's handball. Materials and Methods:
Mojtaba Khansooz +3 more
doaj
Advanced Science, EarlyView.Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang +16 more
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Alanine–Glyoxylate Aminotransferase Sustains Cancer Stemness Properties through the Upregulation of SOX2 and OCT4 in Hepatocellular Carcinoma Cells [PDF]
, 2022 Peng Ye +5 more
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