Results 121 to 130 of about 748 (149)
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Alarmones as Vestiges of a Bygone RNA World
Journal of Molecular Evolution, 2019All known alarmones are ribonucleotides or ribonucleotide derivatives that are synthesized when cells are under stress conditions, triggering a stringent response that affects major processes such as replication, gene expression, and metabolism. The ample phylogenetic distribution of alarmones (e.g., cAMP, Ap(n)A, cGMP, AICAR, and ZTP) suggests that ...
Antonio Lazcano +2 more
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The magic dance of the alarmones (p)ppGpp
Molecular Microbiology, 2016SummaryThe alarmones (p)ppGpp are important second messengers that orchestrate pleiotropic adaptations of bacteria and plant chloroplasts in response to starvation and stress. Here, we review our structural and mechanistic knowledge on (p)ppGpp metabolism including their synthesis, degradation and interconversion by a highly diverse set of enzymes ...
Gert Bange
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Bacterial adaptation to biocides: the possible role of ‘alarmones’
Journal of Hospital Infection, 2001Jean-Yves Maillard +2 more
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Alarmones as bacterial persistence factor
Вестник Пермского университета. Серия «Биология»=Bulletin of Perm University. Biology, 2023 The treatment of bacterial infections with antibiotics is significantly complicated because of the adaptive mechanisms employed by bacteria. Chronic and recurrent infections are often linked to bacterial persis-tence, biofilm formation, and antibiotic tolerance.
Roman Yu. Sidorov +1 more
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2-ketobutyrate: A putative alarmone of Escherichia coli
Molecular and General Genetics MGG, 19832-ketobutyrate is synthesized from threonine by threonine deaminase (dehydratase) in E. coli. The effects of 2-ketobutyrate as a regulatory metabolite were studied in vivo. 2-ketobutyrate was shown to inhibit the phosphoenolpyruvate (PEP): sugar phosphotransferase system resulting in aspartate starvation, elevation of ppGpp endogenous pools, and ...
J, Daniel, L, Dondon, A, Danchin
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The Alarmone (p)ppGpp Regulates Primer Extension by Bacterial Primase
Journal of Molecular Biology, 2021Primase is an essential component of the DNA replication machinery, responsible for synthesizing RNA primers that initiate leading and lagging strand DNA synthesis. Bacterial primase activity can be regulated by the starvation-inducible nucleotide (p)ppGpp. This regulation contributes to a timely inhibition of DNA replication upon amino acid starvation
Christina N, Giramma +2 more
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Regulation of nitrogen starvation responses by the alarmone (p)ppGpp in rice
Journal of Genetics and Genomics, 2022Nitrogen is an essential macronutrient for all living organisms and is critical for crop productivity and quality. In higher plants, inorganic nitrogen is absorbed through roots and then assimilated into amino acids by the highly conserved glutamine synthetase/glutamine:2-oxoglutarate aminotransferase (GS/GOGAT) cycle.
Hanwen Li +18 more
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Selective Fluorescent Chemosensor for the Bacterial Alarmone (p)ppGpp
Journal of the American Chemical Society, 2008We have developed the first selective fluorescent chemosensor (PyDPA) for (p)ppGpp, a bacterial and plant alarmone. By using pyrene-excimer fluorescence, PyDPA shows very good selectivity for (p)ppGpp from among other nucleotides in water. PyDPA was used for the real-time detection of in vitro ppGpp synthesis by bacterial ribosomal complexes.
Rhee, Hyun-Woo +7 more
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