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Concentration matters!! ppGpp, from a whispering to a strident alarmone

Molecular Microbiology, 2011
SummaryBacteria have developed sophisticated signal transduction pathways to sense and respond to environmental stresses. These pathways include intracellular regulators that elicit adaptive changes in the physiology of the cell. Extensive work, mostly performed in Escherichia coli, showed that the modified nucleotide ppGpp plays a key regulatory role ...
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Alarmone-dependent regulators in Rhizobium etli.

Communications in agricultural and applied biological sciences, 2011
info:eu-repo/semantics ...
Vercruysse, M   +2 more
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Do stalled replication forks synthesize a specific alarmone?

Journal of Theoretical Biology, 1983
Potential causes of premature arrest of a replication fork in vivo include an encounter with a chemical lesion in the DNA, inhibition of one of the essential enzymes of the fork, and spontaneous failure of the fork due to its finite degree of processivity.
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Regulatory Themes and Variations by the Stress-Signaling Nucleotide Alarmones (p)ppGpp in Bacteria

Annual Review of Genetics, 2021
Jue D Wang   +2 more
exaly  

Molecular Mechanism of Regulation of the Purine Salvage Enzyme XPRT by the Alarmones pppGpp, ppGpp, and pGpp

Journal of Molecular Biology, 2020
Kenneth Andrew Satyshur   +2 more
exaly  

The alarmones (p)ppGpp directly regulate translation initiation during entry into quiescence

Proceedings of the National Academy of Sciences of the United States of America, 2020
Kelvin Caban   +2 more
exaly  

Np 4 A alarmones function in bacteria as precursors to RNA caps

Proceedings of the National Academy of Sciences of the United States of America, 2020
Joel Belasco   +2 more
exaly  

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