A Cell-Based Screen Reveals that the Albendazole Metabolite, Albendazole Sulfone, Targets Wolbachia [PDF]
PLoS Pathogens, 2012 Wolbachia endosymbionts carried by filarial nematodes give rise to the neglected diseases African river blindness and lymphatic filariasis afflicting millions worldwide.
Pamela M White +2 more
exaly +3 more sources
Analytical Method for the Simultaneous Determination of Albendazole and Metabolites Using HPLC-PDA: A Validation Study [PDF]
MoleculesAlbendazole is an anthelmintic drug commonly used in animals and humans against nematodes. A sensitive, accurate, precise, and time-saving high-performance liquid chromatography (HPLC) method for the simultaneous determination of albendazole and ...
Nelida Fernandez +2 more
exaly +4 more sources
Modification of albendazole pharmacokinetics by menbutone administration in calves [PDF]
Frontiers in Veterinary ScienceOptimizing the use of the existing anthelmintics has become a priority, as resistance is a growing concern worldwide and the development of novel antiparasitic drugs slow.
E. Milena Vazquez +7 more
doaj +2 more sources
Improvement of Albendazole Bioavailability with Menbutone Administration in Sheep
Animals, 2022 The pharmacokinetic interaction between a benzimidazole (albendazole, ABZ) and a choleretic drug (menbutone, MEN) was evaluated in sheep. The plasma disposition of albendazole sulfoxide (ABZSO, active metabolite) and albendazole sulfone (ABZSO2, inactive
Juan José García Vieitez +2 more
exaly +3 more sources
Separation Science Plus, 2021 Abstract The benzimidazole anthelmintic drug albendazole becomes metabolized to chiral albendazole sulfoxide, albendazole sulfone, albendazole 2‐aminosulfone, and other metabolites. High‐performance liquid chromatography with UV absorbance and fluorescence detection, liquid chromatography with mass spectrometry, and chiral electrokinetic chromatography
Wolfgang Thormann +2 more
exaly +2 more sources
Earthworm gut microbiome promotes biodegradation of albendazole in soil [PDF]
Crop HealthThe excretion of the anthelmintic drug albendazole (ALB) from treated animals into the soil, as well as its widespread application as a fungicide, poses a serious ecological risk to the soil environment.
Jiao Wang +7 more
doaj +2 more sources
Ionic liquid-based dispersive liquid-liquid microextraction of anthelmintic drug residues in small-stock meat followed by LC-ESI-MS/MS detection. [PDF]
Food Sci Nutr, 2023 The work is on development and validation of a green sample preparation method for the extraction of anthelmintic drugs from caprine and ovine. Abstract An ionic liquid‐based dispersive liquid–liquid microextraction (IL‐DLLME) of 20 anthelmintic drugs followed and detected by liquid chromatography–tandem mass spectrometry (LC–MS/MS) has been developed,
Tshepho R, Dube S, Nindi MM.
europepmc +2 more sources
Understanding Drug Exposure and Trichuris trichiura Cure Rates: A Pharmacometric Approach for Albendazole-Ivermectin Co-medication in Tanzania and Côte d’Ivoire [PDF]
Drugs in R&DBackground and Objective Trichuriasis caused by the human whipworm Trichuris trichiura poses a significant public health concern. Albendazole-ivermectin co-medication is currently the most effective treatment.
Veshni Pillay-Fuentes Lorente +11 more
doaj +2 more sources
Pharmacokinetics and tissue residues of albendazole sulphoxide and its metabolites in donkey after intramuscular injection. [PDF]
Vet Med SciThe results revealed that ABZSO2 was the main metabolite of ABZSO in donkey plasma. The concentrations of ABZSO and its cheif metabolite (ABZSO2) were detected in liver, kidney, skin and muscle; however, ABZ‐SO2NH2 was only detected in liver and kidney. Abstract Background Various anti‐parasitic drugs are used to control donkey parasitic diseases.
Li Z, Qin X, Wang C, Liu W.
europepmc +2 more sources
Pharmacokinetics of Albendazole, Albendazole Sulfoxide, and Albendazole Sulfone Determined from Plasma, Blood, Dried-Blood Spots, and Mitra Samples of Hookworm-Infected Adolescents. [PDF]
Antimicrobial Agents and Chemotherapy, 2019 Anna Neodo +2 more
exaly +2 more sources