Melatonin in Combination with Albendazole or Albendazole Sulfoxide Produces a Synergistic Cytotoxicity against Malignant Glioma Cells through Autophagy and Apoptosis [PDF]
Brain Sciences, 2023 Glioblastoma is the most aggressive and lethal brain tumor in adults, presenting diffuse brain infiltration, necrosis, and drug resistance. Although new drugs have been approved for recurrent patients, the median survival rate is two years; therefore ...
, Benjamin Pineda, Helgi Jung-Cook
exaly +6 more sources
Liquid chromatography--tandem mass spectrometry method for simultaneous determination of albendazole and albendazole sulfoxide in human plasma for bioequivalence studies [PDF]
Journal of Pharmaceutical Analysis, 2016 An improved high performance liquid chromatography--tandem mass spectrometry (LC–MS/MS) method has been developed for sensitive and rapid determination of albendazole (ABZ) and its active metabolite, albendazole sulfoxide (ABZSO), in the positive ...
Mallika Sanyal +2 more
exaly +6 more sources
Albendazole Sulfoxide Plasma Levels and Efficacy of Antiparasitic Treatment in Patients With Parenchymal Neurocysticercosis [PDF]
Clinical Infectious Diseases, 2019 AbstractBackgroundThe efficacy of albendazole therapy in patients with parenchymal neurocysticercosis (NCC) is suboptimal. Plasma levels of albendazole sulfoxide (ASOX), the active metabolite of albendazole, are highly variable among patients. We hypothesized that high ASOX plasma levels during albendazole therapy may be associated with an increased ...
Holger Maita-Malpartida +2 more
exaly +5 more sources
In vitro analysis of albendazole sulfoxide enantiomers shows that (+)-(R)-albendazole sulfoxide is the active enantiomer against Taenia solium. [PDF]
Antimicrob Agents Chemother, 2013 ABSTRACTAlbendazole is an anthelmintic drug widely used in the treatment of neurocysticercosis (NCC), an infection of the brain withTaenia soliumcysts. However, drug levels of its active metabolite, albendazole sulfoxide (ABZSO), are erratic, likely resulting in decreased efficacy and suboptimal cure rates in NCC.
Paredes A +10 more
europepmc +6 more sources
Modification of albendazole pharmacokinetics by menbutone administration in calves [PDF]
Frontiers in Veterinary ScienceOptimizing the use of the existing anthelmintics has become a priority, as resistance is a growing concern worldwide and the development of novel antiparasitic drugs slow.
E. Milena Vazquez +7 more
doaj +2 more sources
Exposure of Heligmosomoides polygyrus and Trichuris muris to albendazole, albendazole sulfoxide, mebendazole and oxantel pamoate in vitro and in vivo to elucidate the pathway of drug entry into these gastrointestinal nematodes [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2017 Millions of people are treated with anthelmintics to control soil-transmitted helminth infections; yet, drug distribution in the plasma and gastrointestinal tract compartments and the pathway of drug uptake into gastrointestinal nematodes responsible for
Noemi Cowan +3 more
doaj +2 more sources
Pharmacokinetics of Albendazole, Albendazole Sulfoxide, and Albendazole Sulfone Determined from Plasma, Blood, Dried-Blood Spots, and Mitra Samples of Hookworm-Infected Adolescents. [PDF]
Antimicrob Agents Chemother, 2019 Albendazole is an effective anthelmintic intensively used for decades. However, profound pharmacokinetic (PK) characterization is missing in children, the population mostly affected by helminth infections.
Schulz JD +3 more
europepmc +5 more sources
Analytical Method for the Simultaneous Determination of Albendazole and Metabolites Using HPLC-PDA: A Validation Study [PDF]
MoleculesAlbendazole is an anthelmintic drug commonly used in animals and humans against nematodes. A sensitive, accurate, precise, and time-saving high-performance liquid chromatography (HPLC) method for the simultaneous determination of albendazole and ...
E. Milena Vázquez +8 more
doaj +2 more sources
Albendazole specifically disrupts microtubules and protein turnover in the tegument of the cestode Mesocestoides corti. [PDF]
PLoS PathogensParasitic flatworms, such as cestodes and trematodes, are covered by a syncytial tissue known as the tegument. It consists of a superficial band of cytoplasm (the distal tegument) that is connected by cytoplasmic bridges to multiple cell bodies (cytons ...
Inés Guarnaschelli, Uriel Koziol
doaj +2 more sources
Investigation of a fully mechanistic physiologically based pharmacokinetics model of absorption to support predictions of milk concentrations in breastfeeding women and the exposure of infants: A case study for albendazole [PDF]
CPT: Pharmacometrics & Systems PharmacologyDue to limited non‐clinical and clinical data, European guidance recommends to discontinue breastfeeding when taking albendazole. The aim of this study was to consider the use of PBPK modeling to support the expected exposure in breastfed infants.
Susan Cole +4 more
doaj +2 more sources