Results 11 to 20 of about 1,204 (151)

Understanding Drug Exposure and Trichuris trichiura Cure Rates: A Pharmacometric Approach for Albendazole-Ivermectin Co-medication in Tanzania and Côte d’Ivoire [PDF]

Drugs in R&D
Background and Objective Trichuriasis caused by the human whipworm Trichuris trichiura poses a significant public health concern. Albendazole-ivermectin co-medication is currently the most effective treatment.
Veshni Pillay-Fuentes Lorente, Jacinta N. Nwogu-Attah, Britta Steffens, Dominic Bräm, Viviane Sprecher, Daniela Hofmann, Michael Buettcher, Goonaseelan Pillai, Samer Mouksassi, Jean Coulibaly, Marc Pfister, Jennifer Keiser   +11 more
doaj   +2 more sources

A high-throughput LC-MS/MS method for simultaneous analysis of albendazole, albendazole sulfoxide and albendazole sulfone in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Albendazole is a benzimidazole derivative with a broad spectrum of antihelmintic activity. Its primary metabolite, albendazole sulfoxide, is responsible for the treatment's efficacy. On the other hand, it contributes to side effects and toxicity. Therefore, their quantification in plasma may increase therapeutic success and reduce associated risks by ...
Martin Kertys, Robert Rosoľanka
exaly   +3 more sources

ASYMMETRIC SULFOXIDATION OF ALBENDAZOLE TO RICOBENDAZOLE BY FUNGI: EFFECT OF pH

Química Nova, 2015
Albendazole (ABZ) is an anthelmintic drug used for the treatment of infectious diseases in veterinary and human medicine. This drug is a prochiral drug that after administration, is rapidly oxidized in the pharmacologically active sulfoxide metabolite ...
Thiago Barth, Viviane C. Hilário, Bruno A. Rocha, Niege A. J. C. Furtado, Mônica T. Pupo, Anderson R. M. de Oliveira   +5 more
doaj   +3 more sources

In Vitro Evaluation of Esters of Quinoxaline-1,4-di-N-oxide Derivatives as New Antitaeniasis Agents and Their Inhibitory Activity Against Triosephosphate Isomerase [PDF]

Pharmaceuticals
Background/Objectives: Pork tapeworm Taenia solium is the causative agent of cysticercosis which may develop in muscle tissue, skin, eyes, and the central nervous system (neurocysticercosis).
Francisca Palomares-Alonso, Alonzo González-González, Alma D. Paz-González, Eyra Ortiz-Pérez, Ana Verónica Martínez-Vázquez, Itzhel García-Torres, Gabriel López-Velázquez, Helgi Jung-Cook, Gildardo Rivera   +8 more
doaj   +2 more sources

Compound Library Screening Identified Cladribine as a Novel Radiosensitizer for Prostate Cancer. [PDF]

Cancer Sci
The combination of cladribine and irradiation significantly suppressed the growth of DU145‐derived tumors compared with the DMSO plus irradiation group in the mouse model. In addition, it also elevated the percentage of γH2AX‐positive cells after irradiation.
Oka T, Hatano K, Katsuki S, Kanaki T, Inoguchi S, Tani M, Yoshimura A, Horibe Y, Liu Y, Sassi N, Okuda Y, Yamamoto A, Uemura T, Yamamichi G, Ishizuya Y, Hayashi T, Yamamoto Y, Kato T, Kawashima A, Tamari K, Lin B, Tani A, Tsujikawa K, Takahashi Y, Ogawa K, Lupold SE, Nonomura N.   +26 more
europepmc   +2 more sources

Factors associated with variation in single-dose albendazole pharmacokinetics: A systematic review and modelling analysis.

PLoS Neglected Tropical Diseases, 2022
BackgroundAlbendazole is an orally administered anti-parasitic medication with widespread usage in a variety of both programmatic and clinical contexts.
Charles Whittaker, Cédric B Chesnais, Sébastien D S Pion, Joseph Kamgno, Martin Walker, Maria-Gloria Basáñez, Michel Boussinesq   +6 more
doaj   +1 more source

Assessment of Anthelmintic Resistance in Major Gastrointestinal Nematodes in Sheep and Goat Farms in Mymensingh, Bangladesh. [PDF]

J Parasitol Res
Anthelmintic resistance (AR) is a well concern in livestock production. Hence, the study was designed to assess the status of AR in sheep and goat farms at Mymensingh sadar using fecal egg count reduction test (FECRT) and egg hatch assay (EHA). To do this, 10 farms were selected. For FECRT, 40 animals of each farm having more than 200 EPG of feces were
Islam MR, Mizan MMH, Anisuzzaman, Khatun MS, Ashad FA, Alam MZ, Roy BC, Dey AR.   +7 more
europepmc   +2 more sources

High-Fat Breakfast Increases Bioavailability of Albendazole Compared to Low-Fat Breakfast: Single-Dose Study in Healthy Subjects

Frontiers in Pharmacology, 2021
Purpose: Albendazole is a benzimidazole carbamate drug with anthelmintic and antiprotozoal activity against intestinal and tissue parasites. It has been described that the administration with meals increases albendazole absorption. Our aim was to compare
Dolores Ochoa, Dolores Ochoa, Miriam Saiz-Rodríguez, Miriam Saiz-Rodríguez, Esperanza González-Rojano, Manuel Román, Manuel Román, Sergio Sánchez-Rojas, Aneta Wojnicz, Ana Ruiz-Nuño, Alfredo García-Arieta, Francisco Abad-Santos, Francisco Abad-Santos   +12 more
doaj   +1 more source

LC-MS/MS METHOD FOR THE DETERMINATION OF DIAZOLIC ANTHELMINTIC DRUG LEVELS FROM SHEEP AND HUMAN PLASMA FOR USE IN PHARMACOKINETIC AND BIOAVAILABILITY STUDIES

Studia Universitatis Babes-Bolyai Chemia, 2021
. A new high-throughput, inexpensive and selective LC-MS method for determining fenbendazole, albendazole and albendazole sulfoxide from human and ovine plasma was developed and validated in accordance with current guidelines in bioanalysis.
Lénárd FARCZÁDI, Silvia IMRE, Laurian VLASE   +2 more
doaj   +1 more source

Improvement of Albendazole Bioavailability with Menbutone Administration in Sheep

Animals, 2022
The pharmacokinetic interaction between a benzimidazole (albendazole, ABZ) and a choleretic drug (menbutone, MEN) was evaluated in sheep. The plasma disposition of albendazole sulfoxide (ABZSO, active metabolite) and albendazole sulfone (ABZSO2, inactive
Raquel Diez, M. Jose Diez, Juan J. Garcia, Jose M. Rodríguez, Cristina Lopez, Nelida Fernandez, Matilde Sierra, Ana M. Sahagun   +7 more
doaj   +1 more source