Results 11 to 20 of about 1,189 (125)

LC-MS/MS METHOD FOR THE DETERMINATION OF DIAZOLIC ANTHELMINTIC DRUG LEVELS FROM SHEEP AND HUMAN PLASMA FOR USE IN PHARMACOKINETIC AND BIOAVAILABILITY STUDIES

Studia Universitatis Babes-Bolyai Chemia, 2021
. A new high-throughput, inexpensive and selective LC-MS method for determining fenbendazole, albendazole and albendazole sulfoxide from human and ovine plasma was developed and validated in accordance with current guidelines in bioanalysis.
Lénárd FARCZÁDI, Silvia IMRE, Laurian VLASE   +2 more
doaj   +1 more source

Compound Library Screening Identified Cladribine as a Novel Radiosensitizer for Prostate Cancer. [PDF]

Cancer Sci
The combination of cladribine and irradiation significantly suppressed the growth of DU145‐derived tumors compared with the DMSO plus irradiation group in the mouse model. In addition, it also elevated the percentage of γH2AX‐positive cells after irradiation.
Oka T, Hatano K, Katsuki S, Kanaki T, Inoguchi S, Tani M, Yoshimura A, Horibe Y, Liu Y, Sassi N, Okuda Y, Yamamoto A, Uemura T, Yamamichi G, Ishizuya Y, Hayashi T, Yamamoto Y, Kato T, Kawashima A, Tamari K, Lin B, Tani A, Tsujikawa K, Takahashi Y, Ogawa K, Lupold SE, Nonomura N.   +26 more
europepmc   +2 more sources

Improvement of Albendazole Bioavailability with Menbutone Administration in Sheep

Animals, 2022
The pharmacokinetic interaction between a benzimidazole (albendazole, ABZ) and a choleretic drug (menbutone, MEN) was evaluated in sheep. The plasma disposition of albendazole sulfoxide (ABZSO, active metabolite) and albendazole sulfone (ABZSO2, inactive
Raquel Diez, M. Jose Diez, Juan J. Garcia, Jose M. Rodríguez, Cristina Lopez, Nelida Fernandez, Matilde Sierra, Ana M. Sahagun   +7 more
doaj   +1 more source

Giardia duodenalis: Flavohemoglobin is involved in drug biotransformation and resistance to albendazole

PLoS Pathogens, 2022
Giardia duodenalis causes giardiasis, a major diarrheal disease in humans worldwide whose treatment relies mainly on metronidazole (MTZ) and albendazole (ABZ).
Edar O. Pech-Santiago, Raúl Argüello-García, Citlali Vázquez, Emma Saavedra, Iliana González-Hernández, Helgi Jung-Cook, Steven P. Rafferty, M. Guadalupe Ortega-Pierres   +7 more
doaj   +2 more sources

Validation of high performance liquid chromatography coupled to mass spectrometry to determine albendazole sulfoxide in human plasma [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2022
Context: Albendazole is used in the treatment of cysticercosis and hydatid disease, and its prolonged administration can generate adverse effects attributed to the active metabolite, albendazole sulfoxide (ABZSO), whose measurement requires validated ...
Jaime Rosales-Rimache, Saúl Santiváñez, Luis Moreno-Exebio, Miguel Grande, María Flores-Rodríguez, María Eguiluz, Hugo García   +6 more
doaj   +1 more source

Assessment of Anthelmintic Resistance in Major Gastrointestinal Nematodes in Sheep and Goat Farms in Mymensingh, Bangladesh. [PDF]

J Parasitol Res
Anthelmintic resistance (AR) is a well concern in livestock production. Hence, the study was designed to assess the status of AR in sheep and goat farms at Mymensingh sadar using fecal egg count reduction test (FECRT) and egg hatch assay (EHA). To do this, 10 farms were selected. For FECRT, 40 animals of each farm having more than 200 EPG of feces were
Islam MR, Mizan MMH, Anisuzzaman, Khatun MS, Ashad FA, Alam MZ, Roy BC, Dey AR.   +7 more
europepmc   +2 more sources

SCOLICIDAL EFFICACY OF SELENIUM NANOPARTICLES AGAINST PROTOSCOLECES OF HYDATID CYST [PDF]

Journal of the Egyptian Society of Parasitology, 2018
The hydatid disease known as hydatidosis or echinococcosis is a cyclozoonotic disease widely distributed in the viscera and other organs of humans and animals.
SALWA OSHIBA, AMERA AFIFI
doaj   +1 more source

Analysis of the effect of in vitro dissolution on the pharmacokinetics of albendazole

Brazilian Journal of Pharmaceutical Sciences, 2023
Albendazole is an anthelmintic drug commonly used in parenchymal neurocysticercosis and cystic echinococcosis. The aim of this study was to explore whether disparities in the dissolution profiles of albendazole products lead to significant differences in
Nelly Castro, Iliana González-Hernández, Lourdes Mayet-Cruz, José Becerril-Vega, Sergio Soto-Romo, Helgi Jung-Cook   +5 more
doaj   +1 more source

Probing Cinnamamides and Benzamides as Anthelmintics: Discovery of Potent Drug-Like Agents Against Angiostrongylus cantonensis. [PDF]

Chem Biol Drug Des
Cynnamoyl benzylpiperazine was identified as drug‐like derivative of cinnarizine with anthelmintic activity against A. cantonensis. In this work, 15 out of 31 derivatives showed improved anthelmintic activity with increased solubility. A SAR study was carried out to determine the molecular features involved in such effect.
Lemes BL, Siegl-Breno MA, Varela MT, Lopes FB, Silva-Nunes MK, Santos TD, Fukui-Silva L, Roquini DB, Maltarollo VG, de Moraes J, Fernandes JPS.   +10 more
europepmc   +2 more sources

Determination of albendazole and metabolites in silkworm Bombyx mori hemolymph by ultrafast liquid chromatography tandem triple quadrupole mass spectrometry. [PDF]

PLoS ONE, 2014
Albendazole is a broad-spectrum parasiticide with high effectiveness and low host toxicity. No method is currently available for measuring albendazole and its metabolites in silkworm hemolymph.
Li Li, Dong-Xu Xing, Qing-Rong Li, Yang Xiao, Ming-Qiang Ye, Qiong Yang   +5 more
doaj   +1 more source