Results 41 to 50 of about 1,189 (125)

Immobilization of cytochrome P450 enzymes onto magnetic beads: An approach to drug metabolism and biocatalysis

Talanta Open, 2023
Cytochrome P450 (CYP, P450) presents a wide range of applicability in drug metabolism studies and in biocatalysis as a great alternative to synthesizing compounds. Nonetheless, their lack of stability is one of their major drawbacks.
Izadora Liranço Furlani, Regina Vincenzi Oliveira, Quezia Bezerra Cass   +2 more
doaj   +1 more source

Piplartine as an Innovative Natural Product With Dual Antiparasitic and Immunomodulatory Actions

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Neglected tropical diseases (NTDs) remain a major global health burden, disproportionately affecting low‐ and middle‐income regions and demanding innovative therapeutic strategies. This review summarizes current evidence on piplartine (piperlongumine), a naturally occurring amide from Piper species with broad antiparasitic and immunomodulatory ...
Lucas Fukui-Silva, Felipe C. R. de Souza, Camila S. Amorim, Josué de Moraes, Poorani Gurumallesh Prabu   +4 more
wiley   +1 more source

Albendazole metabolism in patients with neurocysticercosis: antipyrine as a multifunctional marker drug of cytochrome P450

Brazilian Journal of Medical and Biological Research, 2002
The present study investigates the isoform(s) of cytochrome P450 (CYP) involved in the metabolism of albendazole sulfoxide (ASOX) to albendazole sulfone (ASON) in patients with neurocysticercosis using antipyrine as a multifunctional marker drug.
M.P. Marques, O.M. Takayanagui, V.L. Lanchote   +2 more
doaj   +1 more source

Comprehensive Evaluation of Methanolic Fruits Extract of Jatropha gossypifolia L.: Neuropharmacological, Cytotoxic, Anthelmintic, GC–MS Profiling, and Molecular Docking Studies

Pharmacology Research &Perspectives, Volume 13, Issue 6, December 2025.
The anxiolytic properties of the methanolic fruit extract of Jatropha gossypifolia (JGF‐ME) were investigated using the Elevated Plus Maze (EPM), Hole Board Test (HBT), and Light–Dark Box Test (LDT), while its antidepressant potential was examined through the Forced Swimming Test (FST) and Tail Suspension Test (TST).
Md. Arafat, Nusrat Jahan Moon, Mahathir Mohammad, Md. Jahirul Islam Mamun, Jannatul Naima Meem, Md. Hossain Rasel, Borhan Uddin, Md. Safayat Hossen Momen, Md. Liakot Ali, Neamul Hoque, S. M. Moazzem Hossen   +10 more
wiley   +1 more source

Anti‐Inflammatory and Antibacterial Properties of Curcuma longa Extract Against Helicobacter pylori

Molecular Nutrition &Food Research, Volume 69, Issue 20, October 2025.
This study explored the effects of Curcuma longa extract (CLE) against H. pylori infection. CLE contained 18 chemical compounds and completely inhibited growth of H. pylori Sydney strain 1 (SS1) in vitro. In infected mice with H. pylori SS1, oral administration of CLE successfully eradicated H.
Jeongsook Kim, Kwan‐Woo Kim, Jin‐Kyu Jang, Myoung Jin Kim, Akila Cooray, Young‐Seob Lee, Kyu Pil Lee, Dae Young Lee   +7 more
wiley   +1 more source

Solvent‐Controlled, Catalyst‐Free Aerobic Photooxidation of Thioethers to Sulfoxides at 370 nm

ChemistrySelect, Volume 10, Issue 40, October 27, 2025.
Solvent‐controlled; catalyst‐free aerobic photooxidation converts thioethers (sulfides) to sulfoxides using ultraviolet (UV) light from a 370 nm light‐emitting diode (LED) under O2. Protic solvents—2,2,2‐trifluoroethanol (TFE) and ethanol—give up to 100% selectivity and easy isolation. Mechanistic probes support a singlet‐oxygen (1O2) pathway.
Pijush Kanti Roy, Yutaka Hitomi
wiley   +1 more source

Anthelminthic activity of glibenclamide on secondary cystic echinococcosis in mice. [PDF]

PLoS Neglected Tropical Diseases, 2017
Cystic echinococcosis (CE) is a worldwide parasitic zoonosis caused by the larval stage of Echinococcus granulosus. Current chemotherapy against this disease is based on the administration of benzimidazoles (BZMs).
Julia A Loos, María Sandra Churio, Andrea C Cumino   +2 more
doaj   +1 more source

Thiostrepton Suppresses the Progression of Rhabdomyosarcoma by Inhibiting the PI3K‐AKT Signaling Pathway

Pediatric Discovery, Volume 3, Issue 3, September 2025.
The study establish TST as a multi‐mechanism PI3K‐AKT inhibitor for refractory RMS while validating Cmap‐driven drug repurposing for pediatric oncology. ABSTRACT Rhabdomyosarcoma (RMS), the most common pediatric soft tissue sarcoma with 5‐year survival below 30% in high‐risk/metastatic cases, was investigated through integrated bioinformatics analysis (
Yu Wang, Peng Hong, Zhiqiang Gao, Wei Ma, Zaihong Hu, Jie Lin, Kongkong Cui, Qinlin Shi, Xiao‐Mao Tian, Guanghui Wei   +9 more
wiley   +1 more source

A single adulticide dose of albendazole induces cytochromes P4501A in mouflon (Ovis musimon) with dicrocoeliosis

Veterinární Medicína, 2007
Contact handling with wild or semi-domesticated animals requires limiting animal stress to minimum. In this respect, single administration of drug should be preferred in contact therapy of mouflon (Ovis musimon) infected by lancet fluke (Dicrocoelium ...
J. Lamka, V. Krizova, V. Cvilink, M. Savlik, J. Velik, L. Duchacek, B. Szotakova, L. Skalova   +7 more
doaj   +1 more source

New benzimidazole derivatives containing hydrazone group as anticancer agents: Inhibition of carbonic anhydrase IX and molecular docking studies

Archiv der Pharmazie, Volume 358, Issue 3, March 2025.
New benzimidazole‐hydrazone derivatives (3a–3j) were designed and synthesized to investigate their effects on carbonic anhydrase (CA) IX and their anticancer activity. Compounds 3d and 3j were found to have the highest activity on CA IX and also showed anticancer properties.
Hayrani Eren Bostancı, Mehmet Taha Yıldız, Serkan Kapancık, Zeynep Deniz Şahin Inan, Hacı Ahmet Kılıç, Özen Özensoy Güler, Ulviye Acar Çevik, Yusuf Özkay, Zafer Asım Kaplancıklı   +8 more
wiley   +1 more source