Results 21 to 30 of about 1,189 (125)

Nanocrystal Suspensions for Enhancing the Oral Absorption of Albendazole

Nanomaterials, 2022
Albendazole (ABZ), an effective benzimidazole antiparasitic drug is limited by its poor solubility and oral bioavailability. In order to overcome its disadvantages, ABZ nanocrystals were prepared using a novel bottom-up method based on acid-base ...
Zhiwei Liang, Min Chen, Yuanyuan Yan, Dongmei Chen, Shuyu Xie   +4 more
doaj   +1 more source

The Use of Cyclodextrin Inclusion Complexes to Increase the Solubility and Pharmacokinetic Profile of Albendazole

Molecules, 2023
Albendazole is the preferred deworming drug and has strong insecticidal effects on human and animal helminth parasites, showing remarkable activity against hepatocellular carcinoma and colorectal cancer cells.
Yili Ding, Zhiyuan Zhang, Charles Ding, Shufeng Xu, Zhe Xu   +4 more
doaj   +1 more source

Effect of nitazoxanide on albendazole pharmacokinetics in cerebrospinal fluid and plasma in rats

Saudi Pharmaceutical Journal, 2017
Background: Although albendazole is the drug-of-choice for the treatment of neurocysticercosis, its efficacy is limited due to its low bioavailability. An alternative for optimizing pharmacological treatment is through drug combinations. In vitro studies
María Isabel Ruiz-Olmedo, Iliana González-Hernández, Francisca Palomares-Alonso, Javier Franco-Pérez, María de Lourdes González F., Helgi Jung-Cook   +5 more
doaj   +1 more source

Pharmacokinetic Characterization and Comparative Bioavailability of an Innovative Orodispersible Fixed-Dose Combination of Ivermectin and Albendazole: A Single Dose, Open Label, Sequence Randomized, Crossover Clinical Trial in Healthy Volunteers

Frontiers in Pharmacology, 2022
Soil-transmitted helminths are intestinal worm diseases transmitted through the soil. Available treatments are albendazole and/or ivermectin. The co-administration of existing drugs is an appropriate strategy.
Jaime Algorta, Alejandro Krolewiecki, Alejandro Krolewiecki, Filipe Pinto, Silvia Gold, Jose Muñoz   +5 more
doaj   +1 more source

Simultaneous Determination of Albendazole and Its Three Metabolites in Pig and Poultry Muscle by Ultrahigh-Performance Liquid Chromatography-Fluorescence Detection

Foods, 2021
A fast, simple and efficient ultrahigh-performance liquid chromatography-fluorescence detection (UPLC-FLD) method for the determination of residues of albendazole (ABZ) and its three metabolites, albendazole sulfone (ABZ-SO2), albendazole sulfoxide (ABZ ...
Zhaoyuan He, Zhixiang Diao, Yawen Guo, Kaizhou Xie, Lan Chen, Chun Xue, Yang Lu, Jinyuan Chen, Tao Zhang   +8 more
doaj   +1 more source

Comparison of albendazole cytotoxicity in terms of metabolite formation in four model systems

Journal of Veterinary Research, 2017
Introduction: Albendazole is used to treat endoparasitic diseases in animals and humans. After oral administration, it is quickly oxidised into its pharmacologically active metabolite albendazole sulfoxide and then to sulfone.
Radko Lidia, Minta Maria, Jedziniak Piotr, Stypuła-Trębas Sylwia   +3 more
doaj   +1 more source

Resistance of bovine gastrointestinal nematodes to four classes of anthelmintics in the semiarid region of Paraíba state, Brazil

Revista Brasileira de Parasitologia Veterinária, 2021
The effectiveness of four anthelmintic classes on cattle gastrointestinal nematodes in the semi-arid region of Paraiba State, Brazil, was evaluated. Twenty farms were used, testing 40 animals in each one, totaling 800 animals.
Lídio Ricardo Bezerra de Melo, Luana Carneiro de Sousa, Clarisse Silva de Menezes Oliveira, Felipe Boniedj Ventura Alvares, Larissa Claudino Ferreira, Roberto Alves Bezerra, Ana Célia Rodrigues Athayde, Thais Ferreira Feitosa, Vinícius Longo Ribeiro Vilela   +8 more
doaj   +1 more source

Developing a Formulation Strategy Coupled with PBPK Modeling and Simulation for the Weakly Basic Drug Albendazole

Pharmaceutics, 2023
Albendazole (ABZ) is a weakly basic drug that undergoes extensive presystemic metabolism after oral administration and converts to its active form albendazole sulfoxide (ABZ_SO).
Harsh Shah, Kushal Shah, Bhavin Gajera, Rutesh H. Dave, David R. Taft   +4 more
doaj   +1 more source

Hapten Synthesis and Monoclonal Antibody Preparation for Simultaneous Detection of Albendazole and Its Metabolites in Animal-Origin Food

Foods, 2021
Albendazole (ABZ) is one of the benzimidazole anthelmintics, and the overuse of ABZ in breeding industry can lead to drug resistance and a variety of toxic effects in humans.
Shibei Shao, Xuping Zhou, Leina Dou, Yuchen Bai, Jiafei Mi, Wenbo Yu, Suxia Zhang, Zhanhui Wang, Kai Wen   +8 more
doaj   +1 more source

First report of multiple anthelmintic resistance in goat farm in Cuba

Helminthologia, 2017
This study determined the efficacies of four classes of anthelmintics (AH) in a goat flock where anthelmintic resistance (AR) to ivermectin was suspected. We selected and randomly distributed 105 animals with >500 eggs per gram of feces into seven groups
Arece-García J., López-Leyva Y., Olmedo-Juárez A., Ramírez-Vargas G., Reyes-Guerrero D., López Arellano Ma. E., De Gives P. Mendoza, Várady M., Rojo-Rubio R., González-Garduño R.   +9 more
doaj   +1 more source