Results 31 to 40 of about 1,189 (125)

Triclabendazole sulfoxide causes stage-dependent embryolethality in zebrafish and mouse in vitro.

PLoS ONE, 2015
BackgroundFascioliasis and paragonimiasis are widespread foodborne trematode diseases, affecting millions of people in more than 75 countries. The treatment of choice for these parasitic diseases is based on triclabendazole, a benzimidazole derivative ...
Nuria Boix, Elisabet Teixido, Marta Vila-Cejudo, Pedro Ortiz, Elena Ibáñez, Juan M Llobet, Marta Barenys   +6 more
doaj   +1 more source

Effect of Sambucus Ebulus Extract and Erythromycin on Albendazole-Induced Histomorphometric Changes in Placenta of Rat

مجله دانشکده پزشکی اصفهان, 2018
Background: There are some reports that albendazole passes placenta and causes disorders in fetus. Besides, there is some evidence that the effect apparently is related to its active metabolite, albendazole sulfoxide.
Mahmood Khaksary-Mahabady, Reza Ranjbar, Hossein Najafzadeh-Varzi, Hasan Morovvati, Elnaz Lak   +4 more
doaj   +1 more source

In vitro effects of tropisetron and granisetron against Echinococcus granulosus (s.s.) protoscoleces by involvement of calcineurin and calmodulin

Parasites & Vectors, 2021
Background Cystic echinococcosis (CE) is a disease caused by the larval stage of Echinococcus granulosus sensu lato  (s.l.). The treatment of CE mainly relies on the use of benzimidazoles, which can commonly cause adverse side effects.
Mohammad Reza Shiee, Eshrat Beigom Kia, Farzaneh Zahabiun, Mahmood Naderi, Elahe Motevaseli, Shahram Nekoeian, Majid Fasihi Harandi, Ahmad Reza Dehpour   +7 more
doaj   +1 more source

Microtubule‐Targeting Drugs Induce Mesenchymal–Epithelial Transition in Hepatic Stellate Cells

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Background and Aims Liver fibrosis is a progressive pathological condition characterized by excessive extracellular matrix accumulation, primarily driven by activated hepatic stellate cells (HSCs). While molecular‐based strategies have been extensively explored for HSC deactivation, clinically effective therapies remain elusive.
Hayato Urushima, Tsutomu Matsubara, Hideto Yuasa, Atsuko Daikoku, Gu Qiongya, Hikaru Nakai, Chiho Kadono, Kazuo Ikeda   +7 more
wiley   +1 more source

Solution‐Processed Nickel Oxide as Efficient Hole Transport Layers in Inverted Perovskite Solar Cells

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This review summarizes recent advances in four mainstream solution‐based techniques for synthesizing NiOx hole‐transport layers for high‐performance perovskite photovoltaic cells, and highlights the key challenges and future prospects for achieving high efficiency, long‐term stability, and low‐cost perovskite photovoltaic technologies toward ...
Zheng Wu, Zeliang Qiu, Yuxin Tao, Yuyang Qiu, Yuwei Duan, Jianxing Xia, Feng Li, Qiang Peng   +7 more
wiley   +1 more source

Efficacy of Albendazole-Chitosan Microsphere-based Treatment for Alveolar Echinococcosis in Mice. [PDF]

PLoS Neglected Tropical Diseases, 2015
This study aimed to investigate the pharmacology and anti-parasitic efficacy of albendazole-chitosan microspheres (ABZ-CS-MPs) for established intraperitoneal infections of Echinococcus multilocularis metacestodes in an experimental murine model.
Maitiseyiti Abulaihaiti, Xiang-Wei Wu, Lei Qiao, Hai-Long Lv, Hong-Wei Zhang, Nasrul Aduwayi, Yan-Jie Wang, Xin-Chun Wang, Xin-Yu Peng   +8 more
doaj   +1 more source

Annona muricata Polyphenols Induce Cytoskeletal Alterations and Predicted Aldose Reductase Binding in Giardia lamblia

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2026, Issue 1, 2026.
Giardiasis has been classified as a neglected disease by the World Health Organization since 2004. Despite ongoing efforts, challenges such as drug resistance and treatment failures continue to hinder effective management. In recent years, the exploration of plant‐derived compounds as antiparasitic agents has emerged as a promising strategy.
Diana Valeria Govea-Flores, Mariana Garza-Ontiveros, Filiberto Gutiérrez-Gutiérrez, Ana Gabriela Gómez-Ibarra, Sendar Daniel Nery-Flores, Juan Alberto Ascacio-Valdés, Lizeth Guadalupe Campos-Múzquiz, Raúl Rodríguez-Herrera, Lissethe Palomo-Ligas, Anjali Chauhan   +9 more
wiley   +1 more source

Pharmacological characterization of geraniol in sheep and its potential use in the control of gastrointestinal nematodes

Veterinary and Animal Science, 2022
Geraniol (GNL) was effective against gastrointestinal nematodes in vitro; nevertheless, the anthelmintic effect of phytochemicals combined with synthetic drugs has been little explored in vivo.
María Victoria Miró, Livio Martins Costa-Júnior, Luis Ignacio Alvarez, Carlos Lanusse, Guillermo Virkel, Adrián Lifschitz   +5 more
doaj   +1 more source

Synthesis, Structural Characterization, and DFT Studies of Fe(III), Co(II), and Ni(II) Mixed‐Ligand Complexes With Albendazole and Nifuroxazide With Molecular Docking Against Respiratory Pathogen Targets

Bioinorganic Chemistry and Applications, Volume 2026, Issue 1, 2026.
In this study, the structural, electronic, and biological characteristics of newly synthesized transition metal complexes FeABNF, CoABNF, and NiABNF, resulting from the chelation compounds albendazole (AB) and nifuroxazide (NF), were studied. The synthesized compounds were found to have excellent yields with high percentage yields (∼80%).
Yousef Aldabayan S., Hany M. Abd El-Lateef, Mai M. Khalaf, Aly Abdou, Guillermo Mendoza-Diaz   +4 more
wiley   +1 more source

Understanding Drug Exposure and Trichuris trichiura Cure Rates: A Pharmacometric Approach for Albendazole-Ivermectin Co-medication in Tanzania and Côte d’Ivoire

Drugs in R&D
Background and Objective Trichuriasis caused by the human whipworm Trichuris trichiura poses a significant public health concern. Albendazole-ivermectin co-medication is currently the most effective treatment.
Veshni Pillay-Fuentes Lorente, Jacinta N. Nwogu-Attah, Britta Steffens, Dominic Bräm, Viviane Sprecher, Daniela Hofmann, Michael Buettcher, Goonaseelan Pillai, Samer Mouksassi, Jean Coulibaly, Marc Pfister, Jennifer Keiser   +11 more
doaj   +1 more source