Results 51 to 60 of about 51,818 (350)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Incubation of penguin eggs [PDF]

, 2003
The preservation of rare and endangered species of birds requires finding efficient, and above all successful, methods of breeding them in captivity. One strategy adopted is to remove eggs from the mother, making her lay more eggs, and then incubating ...
Edwards, Carina, Ovenden, Nick, Rottschäfer, Vivi   +2 more
core  

Qualitative exposure assessment for Salmonella spp. in shell eggs produced on the island of Ireland [PDF]

, 2008
A qualitative exposure assessment for Salmonella in eggs produced on the island of Ireland was developed. The assessment was divided into three main modules (production and packing, distribution and storage, and preparation and consumption), and each of ...
Kelly, Louise, Madden, Robert H., Murchie, Laura, Safefood (Funder), Whyte, Paul, Xia, Bin   +5 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The Effect of Age and Genotype on Quality of Eggs in Brown Egg‑Laying Hybrids

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2019
The aim was to assess the internal and external quality of consumer eggs of egg‑laying hens of two selected genotypes depending on their age. All of these hens were kept in enriched cages. There were compared eggs from Hy‑Line Brown and ISA Brown hens at
Adam Kraus, Lukáš Zita
doaj   +1 more source

Effect of bird age and storage system on physical properties of eggs from brown laying hens [PDF]

, 2010
A total of 108 eggs from a group of 100 brown laying hens housed in standard cages were analyzed. Thirty-six eggs were retired when the hens had 30 week of age, other 36 eggs were retired when the hens had 35 week of age and the remaining 36 eggs were ...
Buxade Carbo, Carlos, Callejo Ramos, Antonio, Cardoso Maciel, William, Daza Andrada, Argimiro, Siqueira de Castro Teixeira, Regis   +4 more
core   +1 more source

Dataset for the proteomic and transcriptomic analyses of perivitelline fluid proteins in Pomacea snail eggs [PDF]

, 2017
This article describes how the proteomic and transcriptomic data were produced during a study of the reproductive proteins of Pomacea maculata, an aquatic apple snail laying colorful aerial eggs, and provides public access to the data.
Chu, Ka Hou, Heras, Horacio, Mu, Huawei, Qiu, Jian Wen, Sun, Jin   +4 more
core   +6 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Metabolomics Approach Reveals the Effects of Breed and Feed on the Composition of Chicken Eggs

Metabolites, 2019
Chicken eggs provide essential nutrients to consumers around the world. Although both genetic and environmental factors influence the quality of eggs, it is unclear how these factors affect the egg traits including egg metabolites.
Tatsuhiko Goto, Hiroki Mori, Shunsuke Shiota, Shozo Tomonaga   +3 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source