Results 31 to 40 of about 1,044,683 (223)

Synergistic effect of microRNA and albumin-bound nanoparticles for inhibition of glioblastoma cancer cell proliferation

Brazilian Journal of Pharmaceutical Sciences, 2020
The functional significance of upregulation miR-34a in combination with albumin-bound paclitaxel nanoparticles in U251 glioblastoma cell line has been evaluated.
Maria Shariatnasery, Shiva Irani, Masoud Soleimani, Navid Goodarzi, Rassoul Dinarvand   +4 more
doaj   +1 more source

A novel preparative method for nanoparticle albumin-bound paclitaxel with high drug loading and its evaluation both in vitro and in vivo.

PLoS ONE, 2021
We developed a novel preparative method for nanoparticle albumin-bound (nab) paclitaxel with high drug loading, which was based on improved paclitaxel solubility in polyethylene glycol (PEG) and self-assembly of paclitaxel in PEG with albumin powders ...
Yue Gao, Jingxue Nai, Zhenbo Yang, Jinbang Zhang, Siyu Ma, Yumei Zhao, Hui Li, Jiaxin Li, Yang Yang, Meiyan Yang, Yuli Wang, Wei Gong, Fanglin Yu, Chunsheng Gao, Zhiping Li, Xingguo Mei   +15 more
doaj   +1 more source

Case Report: Outcome of Osimertinib Treatment in Lung Adenocarcinoma Patients With Acquired KRAS Mutations

Frontiers in Oncology, 2021
BackgroundOsimertinib belongs to the third-generation epidermal growth factor receptor tyrosine kinase inhibitor that has shown positive effects in treating lung adenocarcinoma cancer.
Weigang Xiu, Qianqian Zhang, Min Yu, Yin Huang, Meijuan Huang   +4 more
doaj   +1 more source

Albumin-bound paclitaxel and gemcitabine combination therapy in soft tissue sarcoma [PDF]

BMC Cancer, 2020
Abstract Background: The evidence that albumin-bound paclitaxel (nab-paclitaxel) is safe and efficacious for the treatment of many types of malignant tumors is continuously increasing. However, the evidence and clinical data of nab-paclitaxel and gemcitabine in metastatic soft tissue sarcoma (STS) treatment are rare.
Zhichao Tian, Fan Zhang, Po Li, Jiaqiang Wang, Jinpo Yang, Peng Zhang, Weitao Yao, Xin Wang   +7 more
openaire   +3 more sources

Tailored neoadjuvant epirubicin and cyclophosphamide (EC) and nanoparticle albumin-bound paclitaxel (nab-P) in breast cancer.

, 2022
Tailored neoadjuvant epirubicin and cyclophosphamide (EC) and nanoparticle albumin-bound paclitaxel (nab-P) in breast ...
Karen White (2275696), Caitlin Clare Murphy (13622296), Ian Collins (13064952), Sujata Patil (674937), Conrad Brandt (13622290), Sally E Baron-Hay (13622299), Mustafa Khasraw (13078896), Violet Rudo Mukaro (13622284), Elisabeth Rippy (13622287), David Ashley (13066104), Linda West (6335345), Robert Tobler (13622293)   +11 more
core  

Nanoparticle albumin-bound-paclitaxel: a limited improvement under the current therapeutic paradigm of pancreatic cancer [PDF]

, 2015
Nanoparticle albumin-bound (nab)-paclitaxel is paclitaxel linked to albumin nanoparticles, which makes it soluble and is an example of an application of nanotechnology for cancer treatment.
Hoffman, Robert M, Bouvet, Michael
core   +1 more source

Regression of taxane-related cystoid macular edema after topical dorzolamide treatment: two case reports

Journal of Medical Case Reports, 2021
Background Cystoid macular edema is a rare, vision-threatening side effect of the taxane family of anticancer agents. There is no established treatment or standard treatment protocol for taxane-related cystoid macular edema.
Mitsuru Otsubo, Reiko Kinouchi, Takayuki Kamiya, Akitoshi Yoshida   +3 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Deciphering Anti‐Cancer Drug Efficacy Through Nanomechanical Vibrations in Living Gastric Cancer Organoids

Advanced Science, EarlyView.
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang, Qiubo Chen, Shihai Lan, Liang Zhu, Shuaiyu Liu, Yan Xia, Yalu Zhang, Hanhui Yao, Yongman Liu, Shangquan Wu, Qingchuan Zhang   +10 more
wiley   +1 more source

Nab-Paclitaxel in the Treatment of Gastrointestinal Cancers—Improvements in Clinical Efficacy and Safety

Biomedicines, 2023
Taxanes (paclitaxel and docetaxel) are one of the most useful classes of anticancer drugs. Taxanes are highly hydrophobic; therefore, these drugs must be dissolved in organic solvents (polysorbate or Cremophor EL), which contribute to their toxicities ...
Md Sazzad Hassan, Niranjan Awasthi, Saisantosh Ponna, Urs von Holzen   +3 more
doaj   +1 more source