Results 71 to 80 of about 1,044,683 (223)

Clinical observation of albumin-bound paclitaxel plus nedaplatin as first-line treatment in advanced esophageal squamous cell carcinoma patients

Zhongguo aizheng zazhi, 2020
Background and purpose: Chemotherapy remains the main treatment method for metastatic esophageal squamous cell carcinoma (ESCC). However, no standard regimen has been established as first-line therapy for metastatic ESCC. The purpose of this study was to
颜　芳, 应明真, 陈龙佩, 傅　强   +3 more
doaj  

Retrospective analysis of the effectiveness and tolerability of nab‐paclitaxel in Chinese elderly patients with advanced non‐small‐cell lung carcinoma

Thoracic Cancer, 2020
Background Previous trials have suggested that elderly patients with non‐small‐cell lung cancer (NSCLC) could benefit from nanoparticle albumin‐bound paclitaxel (nab‐paclitaxel). Real‐world data on the elderly Chinese population are lacking.
Shuhang Wang, Qiuping Liang, Yujia Chi, Minglei Zhuo, Tongtong An, Jianchun Duan, Zhijie Wang, Yuyan Wang, Jia Zhong, Xue Yang, Hanxiao Chen, Jie Wang, Jun Zhao   +12 more
doaj   +1 more source

Pre-Clinical Investigation of Liquid Paclitaxel for Local Drug Delivery: A Pilot Study

Pharmaceuticals, 2020
The purpose of this pilot study was to investigate the feasibility of a perfusion catheter to deliver liquid paclitaxel into arterial segments. A clinically relevant rabbit ilio-femoral injury model was utilized to determine the impact of liquid ...
Claire V. Cawthon, Kathryn Cooper, Clifton Huett, Alyssa Lloret, Estefanny Villar-Matamoros, Lauren Stokes, Uwe Christians, Michele Schuler, Saami K. Yazdani   +8 more
doaj   +1 more source

Albumin-bound paclitaxel as new treatment for metastatic cholangiocarcinoma: A case report

World Journal of Clinical Oncology, 2020
Cholangiocarcinomas are rare and very aggressive tumors. Most patients have advanced-stage or unresectable disease at presentation, and the systemic therapies have limited efficacy. Albumin-bound paclitaxel (nab-paclitaxel) is a solvent-free taxane that has been approved for the treatment of some cancers such as breast, non-small cell lung and ...
Martin Huertas, Roberto, Fuentes-Mateos, Raquel, Serrano Domingo, Juan Jose, Corral de la Fuente, Elena, Rodríguez-Garrote, Mercedes   +4 more
openaire   +3 more sources

Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy

Phytotherapy Research, EarlyView.
This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi, LuLu Zhang, Lan Yan, Qi Geng, Li Li, Xiaojuan He, Ning Zhao, Yong Tan, Xiaomeng Zhang, Cheng Lu   +9 more
wiley   +1 more source

Albumin-bound formulation of paclitaxel (Abraxane® ABI-007) in the treatment of breast cancer

, 2009
Evelina Miele1, Gian Paolo Spinelli1, Ermanno Miele2, Federica Tomao1, Silverio Tomao11Department of Experimental Medicine, University of Rome “Sapienza”, Rome, Italy; 2Biomedical Engineering, University of Rome Tor Vergata, Rome ...
Silverio Tomao, Ermanno Miele, Evelina Miele, Gian Paolo Spinelli, Federica Tomao   +4 more
core  

Co-delivery of all- trans -retinoic acid enhances the anti-metastasis effect of albumin-bound paclitaxel nanoparticles [PDF]

, 2016
Co-delivery of all-trans-retinoic acid and paclitaxel using albumin-bound nanoparticles demonstrated a significantly improved anti-metastatic effect to breast cancer both in vitro and in vivo.
Huang, Hai, Shi, Hongdong, Liu, Jing, Min, Yuanzeng, Liu, Yangzhong, Wang, Andrew Z., Wang, Jun, Wang, Yucai   +7 more
core   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

Plant‐Derived Extracellular Vesicles: Biogenesis, Function, and Application in Cancer Immunotherapy

Phytotherapy Research, EarlyView.
This illustration shows the biogenesis pathways of edible and medicinal plant‐derived extracellular vesicles (PDEVs) and their therapeutic effects following uptake in the human body, highlighting their potential for application in cancer immunotherapy. ABSTRACT Plant‐derived extracellular vesicles (PDEVs) are nanoscale, lipid bilayer‐enclosed vesicles ...
Guosheng Li, Mengyu Li, Shujing Liu, Yuan Wei, Chen Wang   +4 more
wiley   +1 more source

Intravenous paclitaxel delivered by a vitamin E nanocarrier as a safe and economical alternative to albumin-bound nanoparticles

Discover Oncology
Background Paclitaxel is a widely used chemotherapeutic agent for solid tumors; however, its clinical application is limited by extremely low aqueous solubility and the use of toxic excipients in conventional formulations.
Amerh A. Alahmadi, Majed A. Alghamdi, Abrar Hakami, Ehab M. M. Ali, Amjad Aljagthmi, Tarek A. Ahmed   +5 more
doaj   +1 more source