Results 131 to 140 of about 1,382,004 (349)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The effect of resistance training on physical function is associated with changes in serum albumin redox state in middle-aged and older Japanese adults: a Quasi-experimental study

Frontiers in Physiology
BackgroundResistance training is important for improving physical function in middle-aged and older adults. The fraction of mercaptoalbumin in total serum albumin, represented as f(HMA), is an indicator of physical function and protein nutritional status
Takuya Shibasaki, Hirohiko Nakamura, Yuka Kurosaka, Shuji Sawada, Kazuhiro Miyaji, Shuichi Machida, Shuichi Machida   +6 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Serum Ischemia-Modified Albumin Concentration and Ischemia-Modified Albumin/Albumin Ratio in Hyperemesis Gravidarum [PDF]

, 2018
Aim:Hyperemesis gravidarum (HEG) is characterized by severe nausea and vomiting, weight loss and nutritional deficiency. Although exact cause of this condition is still a matter of debate, contribution of oxidative stress to pathogenesis of HEG was ...
Eren Pek, Beyazit, Fatma, Turkon, Hakan, Fatma Beyazıt, Hakan Türkön, Pek, Eren   +5 more
core   +1 more source

Factors Influencing the Antifolate Activity of Synthetic Tea-Derived Catechins

Molecules, 2013
Novel tea catechin derivatives have been synthesized, and a structure-activity study, related to the capacity of these and other polyphenols to bind dihydrofolate reductase (DHFR), has been performed.
José Neptuno Rodríguez-López, Alberto Tárraga-Tomás, Nani Mchedlishvili, Soledad Chazarra, María Piedad Fernández-Pérez, Magalí Sáez-Ayala   +5 more
doaj   +1 more source

Strategies for Preparing Albumin-based Nanoparticles for Multifunctional Bioimaging and Drug Delivery

Theranostics, 2017
Biosafety is the primary concern in clinical translation of nanomedicine. As an intrinsic ingredient of human blood without immunogenicity and encouraged by its successful clinical application in Abraxane, albumin has been regarded as a promising ...
Fei-Fei An, Xiaohong Zhang
semanticscholar   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Effect of hydrophilic solvents on enhancing transdermal delivery of albumin [PDF]

Objectives: Transdermal drug delivery suggests several advantages and has been vastly investigated over last decades. Chemical enhancers improve the quantity of drug penetration through the skin.
شکری, نرگس, اکبری جور, حمید, خلج, علی   +2 more
core   +1 more source

The effects of age on associations between markers of HIV progression and markers of metabolic function including albumin, haemoglobin and lipid concentrations. [PDF]

, 2013
We investigated whether age modified associations between markers of HIV progression, CD4 T lymphocyte count and HIV RNA viral load (VL), and the following markers of metabolic function: albumin, haemoglobin, high-density lipoprotein cholesterol (HDL-C),
C Leen, Samuel, M., Chadwick, D, Gompels, Mark, Johnson, M., Anderson, Jane, Leen, Clifford, Samuel, M, Fisher, M., Pillay, Deenan, Orkin, Chloe, Sabin, C, Hay, Phillip, Johnson, M, CA Sabin, M Fisher, Nelson, M., M Johnson, S Jose, Gilson, Richard, Fisher, M, Ainsworth, Jonathan, ?, ?, Johnson, Margaret, Gilson, R, Sabin, C. A., Hay, P, D Chadwick, Gompels, M, R Gilson, Sabin, Ca, Nelson, Mark, UK Collaborative HIV Cohort Study, Palfreeman, Adrian, P Hay, Delpech, Valerie, Fisher, Martin, FA Post, Babiker, Abdel, UK Collaborative HIV Cohort Study (UK CHIC), Chadwick, David, Hay, P., Kegg, Stephen, M Samuel, Gilson, R., Gompels, M., Sachikonye, Memory, Nelson, M, Winston, A, Post, Fa, A Winston, Leen, C., Gazzard, Brian, Post, F A, Jose, S., Post, Frank, M Nelson, Jose, S, Post, F, Chadwick, D., Sabin, C A, Leen, C, Winston, A., M Gompels   +63 more
core   +1 more source

Psoriasis Does Not Seem to Impair Glomerular and Tubular Function – The Comprehensive Study on Serum and Urine

Psoriasis: Targets and Therapy
Julia Nowowiejska,1 Anna Baran,1 Justyna Magdalena Hermanowicz,2 Beata Sieklucka,3 Olga Martyna Koper-Lenkiewicz,4 Joanna Kamińska,4 Krystyna Pawlak,3 Dariusz Pawlak,2 Iwona Flisiak1 1Department of Dermatology and Venereology, Medical University of ...
Nowowiejska J, Baran A, Hermanowicz JM, Sieklucka B, Koper-Lenkiewicz OM, Kamińska J, Pawlak K, Pawlak D, Flisiak I   +8 more
doaj