Results 111 to 120 of about 1,084,443 (309)

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

The effects of age on associations between markers of HIV progression and markers of metabolic function including albumin, haemoglobin and lipid concentrations. [PDF]

, 2013
We investigated whether age modified associations between markers of HIV progression, CD4 T lymphocyte count and HIV RNA viral load (VL), and the following markers of metabolic function: albumin, haemoglobin, high-density lipoprotein cholesterol (HDL-C),
C Leen, Samuel, M., Chadwick, D, Gompels, Mark, Johnson, M., Anderson, Jane, Leen, Clifford, Samuel, M, Fisher, M., Pillay, Deenan, Orkin, Chloe, Sabin, C, Hay, Phillip, Johnson, M, CA Sabin, M Fisher, Nelson, M., M Johnson, S Jose, Gilson, Richard, Fisher, M, Ainsworth, Jonathan, ?, ?, Johnson, Margaret, Gilson, R, Sabin, C. A., Hay, P, D Chadwick, Gompels, M, R Gilson, Sabin, Ca, Nelson, Mark, UK Collaborative HIV Cohort Study, Palfreeman, Adrian, P Hay, Delpech, Valerie, Fisher, Martin, FA Post, Babiker, Abdel, UK Collaborative HIV Cohort Study (UK CHIC), Chadwick, David, Hay, P., Kegg, Stephen, M Samuel, Gilson, R., Gompels, M., Sachikonye, Memory, Nelson, M, Winston, A, Post, Fa, A Winston, Leen, C., Gazzard, Brian, Post, F A, Jose, S., Post, Frank, M Nelson, Jose, S, Post, F, Chadwick, D., Sabin, C A, Leen, C, Winston, A., M Gompels   +63 more
core   +1 more source

Association of Troponin, C-Reactive protein, Albumin and C-Reactive protein/Albumin Ratios with Mortality in Intensive Care Unit Patients with Community-acquired Pneumonia

Acta Medica Alanya
Aim: Parameters used to determine prognosis in community-acquired pneumonia (CAP) patients often have limited clinical value. This study aims to examine the efficacy of CRP, albumin, CRP/albumin ratio and troponin elevation in predicting 30-day mortality
Halil İbrahim Doru, Furkan Akpınar, Şenol Arslan, Nazım Onur Can   +3 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Cross-reaction of affinity purified anti-Amadori-albumin-IgG with various inhibitors as determined by inhibition ELISA.

, 2017
Cross-reaction of affinity purified anti-Amadori-albumin-IgG with various inhibitors as determined by inhibition ELISA.
Zarina Arif (3743155), Km Neelofar (3743152), Jamal Ahmad (3743158), Khursheed Alam (285638)   +3 more
core   +1 more source

The Influence of Diabetes Mellitus and Kidney Dysfunction on Oxidative Stress, a Reflection of the Multisystem Interactions in Aortic Stenosis

Antioxidants
Progression of aortic stenosis (AS) is aggravated by type 2 Diabetes Mellitus (T2DM) and kidney dysfunction (KD). Oxidative stress is one of the main mechanisms that triggers AS and is also disturbed among subjects with T2DM and KD.
Laura Mourino-Alvarez, Inés Perales-Sánchez, Germán Hernández-Fernández, Gabriel Blanco-López, Emilio Blanco-López, Rocío Eiros, Cristian Herrera-Flores, Miryam González-Cebrian, Teresa Tejerina, Jesús Piqueras-Flores, Pedro Luis Sánchez, Luis F. López-Almodóvar, Luis R. Padial, Maria G. Barderas   +13 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Albumin-Stabilized Metal–Organic Nanoparticles for Effective Delivery of Metal Complex Anticancer Drugs

, 2018
Many metal–organic complexes showed potent anticancer efficacy, but their clinical applications were limited by the lack of administration route because of their poor solubility.
Dongdong Li (123985), Bing Xiao, Xiangrui Liu, Jianbin Tang (1561048), Zhuxian Zhou (1509457), Jianbin Tang, Youqing Shen, Youqing Shen (1561042), Hongxia Xu (307676), Bing Xiao (158836), Zhuxian Zhou, Ding Hu (2942190), Xiangrui Liu (1284972), Dongdong Li, Ding Hu, Hongxia Xu   +15 more
core   +1 more source

Both, Limited and Often Fatal Systemic Infections Caused by Leuconostoc spp. in Older, Previously Ill Men Are Usually Acquired in the Outpatient Setting

Microorganisms
Leuconostoc spp. are vancomycin-resistant Gram-positive cocci that are used in food production and as pre- and probiotics. However, Leuconostoc spp. can also cause infections. In the present study, the records of patients with Leuconostoc spp.
Johanna Butt, Cristian Arva, Stefan Borgmann   +2 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source