Results 111 to 120 of about 1,382,004 (349)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Cross-reaction of affinity purified anti-Amadori-albumin-IgG with various inhibitors as determined by inhibition ELISA. [PDF]

, 2017
Cross-reaction of affinity purified anti-Amadori-albumin-IgG with various inhibitors as determined by inhibition ELISA.
Zarina Arif (3743155), Km Neelofar (3743152), Jamal Ahmad (3743158), Khursheed Alam (285638)   +3 more
core   +1 more source

Albumin: a mediator of the association between serum calcium and triglyceride-glucose index among Chinese individuals with osteoporotic fractures

Frontiers in Endocrinology
BackgroundOsteoporotic fractures (OPFs) are a major global health concern, affecting nearly 200 million individuals worldwide. Notably, patients with type 2 diabetes mellitus (T2DM) face a heightened fracture risk, even when bone mineral density (BMD) is
Jia-qi Liang, Jia-qi Liang, Jian Xu, Jian Xu, Yan Cao, Yin-lin Wei, Guo-ji Lin, Guo-ji Lin, Jian Jin, Chong Li, Chong Li, Ke Lu, Ke Lu   +12 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Predictive value of serum uric acid-to-albumin ratio for diabetic kidney disease in patients with type 2 diabetes mellitus: a case-control study

Frontiers in Endocrinology
ObjectiveThe aim of this study was to investigate the predictive effects of the serum uric acid-to-albumin ratio (sUAR) on the onset of diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM).MethodsA case-control study was ...
Jing Du, Xiumei Xu, Ning Yuan, Xiaomei Zhang   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Crystallographic analysis reveals the structural basis of the high-affinity binding of iophenoxic acid to human serum albumin [PDF]

, 2011
23.04.14 KB.
Chung, Chun-wa, Curry, Stephen, Ali J Ryan, Chun-wa Chung, Stephen Curry, Curry, S, Ryan, AJ, Chung, C-W, Ryan, Ali J.   +8 more
core   +1 more source

A Comprehensive Immunocapture-LC-MS/MS Bioanalytical Approach in Support of a Biotherapeutic Ocular PK Study

Pharmaceuticals
BI-X, a therapeutic protein under development for the treatment of human ocular disease via intravitreal administration, binds to its therapeutic targets and endogenous albumin in the vitreous humor.
Lin-Zhi Chen, David Roos, Elsy Philip, Emily G. Werth, Stephanie Kostuk, Hongbin Yu, Holger Fuchs   +6 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Generation of H11-albumin-rtTA transgenic mice: a tool for inducible gene expression in the liver [PDF]

, 2018
We have developed a powerful new transgenic mouse technology that will greatly facilitate mechanistic studies. Very briefly, we generated genomic “safe harbor” Hipp11 (H11) locus-specific knock-in transgenic mice via homologous recombination, and we use ...
wang fengchao (5685602)
core   +1 more source