Results 101 to 110 of about 1,382,004 (349)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Albumin use after cardiac surgery [PDF]

, 2020
To investigate the effect of albumin exposure in ICU after cardiac surgery on hospital mortality, complications, and costs.A retrospective, single-center cohort study with economic evaluation.Cardiothoracic ICU in Australia.Adult patients admitted to the
Ramanan, Mahesh ; https://orcid.org/, Ramanan, Mahesh, Kiran Shekar, Naidoo, Rishendran V, Shekar, Kiran, Matebele, Mbakise P, Cornmell, George, Naidoo, Rishendran V., Mbakise P. Matebele, Kelly Thompson, Thompson, Kelly, Rishendran V. Naidoo, Thompson, Kelly ; https://orcid.org/, Mahesh Ramanan, George Cornmell, Matebele, Mbakise P.   +15 more
core   +2 more sources

Changes in blood serum protein profile in low-yielding ewes during the periparturient period

Open Veterinary Journal
Background: In high-yielding dairy ewes, metabolic and reproductive processes occurring around the time of parturition and during lactation initiation are accompanied by several changes in blood biochemical parameters, including those related to protein
Veronika Glembova, Csilla Tóthova, Veronika Oršuľakova, Oskar Nagy   +3 more
doaj   +1 more source

Effects of Albumin Treatment on Systemic and Portal Hemodynamics and Systemic Inflammation in Patients With Decompensated Cirrhosis.

Gastroenterology, 2019
BACKGROUND & AIMS We investigated the effect of albumin treatment (20% solution) on hypoalbuminemia, cardiocirculatory dysfunction, portal hypertension, and systemic inflammation in patients with decompensated cirrhosis with and without bacterial ...
Javier Fernández, J. Clària, A. Amorós, F. Aguilar, M. Castro, M. Casulleras, J. Acevedo, Marta Duran‐Güell, L. Núñez, M. Costa, M. Torres, R. Horrillo, L. Ruíz‐del‐Árbol, C. Villanueva, V. Prado, M. Arteaga, J. Trebicka, P. Angeli, M. Merli, C. Alessandria, N. Aagaard, G. Soriano, F. Durand, A. Gerbes, T. Gustot, T. Welzel, F. Salerno, R. Bañares, V. Vargas, A. Albillos, Aníbal Silva, M. Morales-Ruiz, Juan Carlos García-Pagán, M. Pavesi, R. Jalan, M. Bernardi, R. Moreau, A. Páez, V. Arroyo   +38 more
semanticscholar   +1 more source

Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets

Nature Communications, 2020
Controlling nanocarrier interactions with the immune system requires a thorough understanding of the surface properties that modulate protein adsorption in biological fluids, since the resulting protein corona redefines cellular interactions with ...
Michael P. Vincent, Sharan Bobbala, Nicholas B. Karabin, Molly A Frey, Yugang Liu, Justin O. Navidzadeh, Trevor Stack, E. Scott   +7 more
semanticscholar   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Comparison of Coasting and Intravenous Albumin in the Prevention of Ovarian Hyperstimulation Syndrome [PDF]

, 2009
OBJECTIVE: To compare the efficacy of coasting to prevent ovarian hyperstimulation syndrome (OHSS) with i.v. albumin and to determine if different timing of gonadotropin coasting would affect the IVF outcomes. DESIGN: Retrospective study.
楊友仕, Chen, Chin-Der; Chao, Kuang-Han; Yang, Jehn-Hsiahn; Chen, Shee-Uan; Ho, Hong-Nerng; Yang, Yu-Shih   +1 more
core  

Albumin-Stabilized Metal–Organic Nanoparticles for Effective Delivery of Metal Complex Anticancer Drugs [PDF]

, 2018
Many metal–organic complexes showed potent anticancer efficacy, but their clinical applications were limited by the lack of administration route because of their poor solubility.
Dongdong Li (123985), Bing Xiao, Xiangrui Liu, Jianbin Tang (1561048), Zhuxian Zhou (1509457), Jianbin Tang, Youqing Shen, Youqing Shen (1561042), Hongxia Xu (307676), Bing Xiao (158836), Zhuxian Zhou, Ding Hu (2942190), Xiangrui Liu (1284972), Dongdong Li, Ding Hu, Hongxia Xu   +15 more
core   +1 more source

Association between Gustave Roussy Immune Score and delay in discharge among children and adolescents with mycoplasma pneumoniae pneumonia: a retrospective cohort study

Frontiers in Pediatrics
BackgroundMycoplasma pneumoniae pneumonia (MPP) is one of the leading causes of hospitalization and death in children. Epidemiological studies have confirmed that single blood indicators such as the neutrophil-to-lymphocyte ratio (NLR), lactic ...
Xu Zhou, Baoqing Zhang, Yanning Li, Xingyou Zhao   +3 more
doaj   +1 more source

Clinical Profile and Predictors of Outcomes in Older Inpatients with Pyelonephritis in a Tertiary Care Hospital in Southern India [PDF]

Journal of Clinical and Diagnostic Research, 2015
Background: Pyelonephritis is a serious infection associated with significant morbidity and mortality in the elderly with an estimated annual incidence rate of around 10% from previous studies. Older people are at a higher risk for pyelonephritis due
Gopinath Kango Gopal, Benny Paul Wilson, Surekha Viggeswarpu, Sowmya Sathyendra, Ramya Iyyadurai, Renuka Visvanathan, Kuruvilla Prasad Mathews   +6 more
doaj   +1 more source