Results 121 to 130 of about 1,382,004 (349)

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Change in the Lipid Transport Capacity of the Liver and Blood during Reproduction in Rats

Frontiers in Physiology, 2017
To support the high energetic demands of reproduction, female mammals display plasticity in many physiological processes, such as the lipid transport system.
Yufeng Zhang, Christine Kallenberg, Hayden W. Hyatt, Andreas N. Kavazis, Wendy R. Hood   +4 more
doaj   +1 more source

Albumin-based drug delivery: harnessing nature to cure disease

Molecular and Cellular Therapies, 2016
The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies.
M. Larsen, M. Kuhlmann, M. L. Hvam, K. Howard   +3 more
semanticscholar   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

POTENTIAL IMPACTS OF PHARMACEUTICAL USES OF TRANSGENIC TOBACCO: THE CASE OF HUMAN SERUM ALBUMIN (HSA) [PDF]

The potential size and distribution of benefits from transgenic tobacco as a source of human serum albumin are estimated using an economic surplus model with imperfect competition.
Kostandini, Genti, Mills, Bradford F., Norton, George W.   +2 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Fibrinogen-to-Albumin Ratio in Neonatal Sepsis [PDF]

, 2023
Geng Dong,1 Tingting Ma,2 Zhe Xu,1 Min Zhang,1 Yidi Hu,1 Junmei Yang,1 Tiewei Li1 1Zhengzhou Key Laboratory of Children’s Infection and Immunity, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s ...
Dong G, Yang J, Hu Y, Li T, Zhang M, Ma T, Xu Z   +6 more
core  

Can Serum Albumin Level At Diagnosis Be A Guide for Clinical Features, Time to Treatment, and Response in Patients with Follicular Lymphoma?

Namık Kemal Tıp Dergisi
Aim: The aim of the present study was to determine the association between serum albumin level and treatment demand, time to treatment and treatment response in patients with follicular lymphoma (FL).
Abdulkadir KARIŞMAZ, Burcu GÜLBAĞCI, Rafet EREN, Ceyda ASLAN, Elif SUYANI   +4 more
doaj   +1 more source

Keefektifan ekstra putih telur terhadap peningkatan albumin dan penurunan IL-1β pada pasien tuberkulosis dengan hipoalbuminemia

Jurnal Gizi Klinik Indonesia, 2014
Background: Tuberculosis (TB) is world health problem which still needs attention. Recently, Indonesia ranks the third in TB prevalence after India and China.
Agus Prastowo, Wiryatun Lestariana, Siti Nurdjanah, Retno Sutomo   +3 more
doaj   +1 more source