Results 41 to 50 of about 900,965 (264)

Changes in blood serum protein profile in low-yielding ewes during the periparturient period

Open Veterinary Journal
Background: In high-yielding dairy ewes, metabolic and reproductive processes occurring around the time of parturition and during lactation initiation are accompanied by several changes in blood biochemical parameters, including those related to protein
Veronika Glembova, Csilla Tóthova, Veronika Oršuľakova, Oskar Nagy   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Association between Gustave Roussy Immune Score and delay in discharge among children and adolescents with mycoplasma pneumoniae pneumonia: a retrospective cohort study

Frontiers in Pediatrics
BackgroundMycoplasma pneumoniae pneumonia (MPP) is one of the leading causes of hospitalization and death in children. Epidemiological studies have confirmed that single blood indicators such as the neutrophil-to-lymphocyte ratio (NLR), lactic ...
Xu Zhou, Baoqing Zhang, Yanning Li, Xingyou Zhao   +3 more
doaj   +1 more source

Clinical Profile and Predictors of Outcomes in Older Inpatients with Pyelonephritis in a Tertiary Care Hospital in Southern India [PDF]

Journal of Clinical and Diagnostic Research, 2015
Background: Pyelonephritis is a serious infection associated with significant morbidity and mortality in the elderly with an estimated annual incidence rate of around 10% from previous studies. Older people are at a higher risk for pyelonephritis due
Gopinath Kango Gopal, Benny Paul Wilson, Surekha Viggeswarpu, Sowmya Sathyendra, Ramya Iyyadurai, Renuka Visvanathan, Kuruvilla Prasad Mathews   +6 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Albumin: a mediator of the association between serum calcium and triglyceride-glucose index among Chinese individuals with osteoporotic fractures

Frontiers in Endocrinology
BackgroundOsteoporotic fractures (OPFs) are a major global health concern, affecting nearly 200 million individuals worldwide. Notably, patients with type 2 diabetes mellitus (T2DM) face a heightened fracture risk, even when bone mineral density (BMD) is
Jia-qi Liang, Jia-qi Liang, Jian Xu, Jian Xu, Yan Cao, Yin-lin Wei, Guo-ji Lin, Guo-ji Lin, Jian Jin, Chong Li, Chong Li, Ke Lu, Ke Lu   +12 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Predictive value of serum uric acid-to-albumin ratio for diabetic kidney disease in patients with type 2 diabetes mellitus: a case-control study

Frontiers in Endocrinology
ObjectiveThe aim of this study was to investigate the predictive effects of the serum uric acid-to-albumin ratio (sUAR) on the onset of diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM).MethodsA case-control study was ...
Jing Du, Xiumei Xu, Ning Yuan, Xiaomei Zhang   +3 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

A Comprehensive Immunocapture-LC-MS/MS Bioanalytical Approach in Support of a Biotherapeutic Ocular PK Study

Pharmaceuticals
BI-X, a therapeutic protein under development for the treatment of human ocular disease via intravitreal administration, binds to its therapeutic targets and endogenous albumin in the vitreous humor.
Lin-Zhi Chen, David Roos, Elsy Philip, Emily G. Werth, Stephanie Kostuk, Hongbin Yu, Holger Fuchs   +6 more
doaj   +1 more source