Results 61 to 70 of about 1,110,362 (306)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Changes in blood serum protein profile in low-yielding ewes during the periparturient period

Open Veterinary Journal
Background: In high-yielding dairy ewes, metabolic and reproductive processes occurring around the time of parturition and during lactation initiation are accompanied by several changes in blood biochemical parameters, including those related to protein
Veronika Glembova, Csilla Tóthova, Veronika Oršuľakova, Oskar Nagy   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Association between Gustave Roussy Immune Score and delay in discharge among children and adolescents with mycoplasma pneumoniae pneumonia: a retrospective cohort study

Frontiers in Pediatrics
BackgroundMycoplasma pneumoniae pneumonia (MPP) is one of the leading causes of hospitalization and death in children. Epidemiological studies have confirmed that single blood indicators such as the neutrophil-to-lymphocyte ratio (NLR), lactic ...
Xu Zhou, Baoqing Zhang, Yanning Li, Xingyou Zhao   +3 more
doaj   +1 more source

Clinical Profile and Predictors of Outcomes in Older Inpatients with Pyelonephritis in a Tertiary Care Hospital in Southern India [PDF]

Journal of Clinical and Diagnostic Research, 2015
Background: Pyelonephritis is a serious infection associated with significant morbidity and mortality in the elderly with an estimated annual incidence rate of around 10% from previous studies. Older people are at a higher risk for pyelonephritis due
Gopinath Kango Gopal, Benny Paul Wilson, Surekha Viggeswarpu, Sowmya Sathyendra, Ramya Iyyadurai, Renuka Visvanathan, Kuruvilla Prasad Mathews   +6 more
doaj   +1 more source

Albumin use after cardiac surgery [PDF]

, 2020
To investigate the effect of albumin exposure in ICU after cardiac surgery on hospital mortality, complications, and costs.A retrospective, single-center cohort study with economic evaluation.Cardiothoracic ICU in Australia.Adult patients admitted to the
Ramanan, Mahesh ; https://orcid.org/, Ramanan, Mahesh, Kiran Shekar, Naidoo, Rishendran V, Shekar, Kiran, Matebele, Mbakise P, Cornmell, George, Naidoo, Rishendran V., Mbakise P. Matebele, Kelly Thompson, Thompson, Kelly, Rishendran V. Naidoo, Thompson, Kelly ; https://orcid.org/, Mahesh Ramanan, George Cornmell, Matebele, Mbakise P.   +15 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Albumin: a mediator of the association between serum calcium and triglyceride-glucose index among Chinese individuals with osteoporotic fractures

Frontiers in Endocrinology
BackgroundOsteoporotic fractures (OPFs) are a major global health concern, affecting nearly 200 million individuals worldwide. Notably, patients with type 2 diabetes mellitus (T2DM) face a heightened fracture risk, even when bone mineral density (BMD) is
Jia-qi Liang, Jia-qi Liang, Jian Xu, Jian Xu, Yan Cao, Yin-lin Wei, Guo-ji Lin, Guo-ji Lin, Jian Jin, Chong Li, Chong Li, Ke Lu, Ke Lu   +12 more
doaj   +1 more source

Serum Ischemia-Modified Albumin Concentration and Ischemia-Modified Albumin/Albumin Ratio in Hyperemesis Gravidarum [PDF]

, 2018
Aim:Hyperemesis gravidarum (HEG) is characterized by severe nausea and vomiting, weight loss and nutritional deficiency. Although exact cause of this condition is still a matter of debate, contribution of oxidative stress to pathogenesis of HEG was ...
Eren Pek, Beyazit, Fatma, Turkon, Hakan, Fatma Beyazıt, Hakan Türkön, Pek, Eren   +5 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source