Results 51 to 60 of about 1,507,102 (353)

Allosteric modulation of zinc speciation by fatty acids [PDF]

Background: Serum albumin is the major protein component of blood plasma and is responsible for the circulatory transport of a range of small molecules that include fatty acids, hormones, metal ions and drugs.
Barnett, James P., Dr., Blindauer, Claudia A., Kassaar, Omar, Khazaipoul, Siavash, Martin, Esther M., Sadler, P. J., Stewart, Alan J. S.   +6 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Blood urea nitrogen-to-albumin ratio as a new prognostic indicator of 1-year all-cause mortality in patients with IPF

Frontiers in Medicine
BackgroundIdiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by chronic inflammation and progressive fibrosis. The blood urea nitrogen-to-albumin ratio (BAR) is a comprehensive parameter associated with inflammation status;
Shaobo Ge, Yuer Li, Rui Li, Jin Liu, Rui Zhang, Hongyan Fu, Jingjing Tang, Jie Zhang, Nali Zhang, Ming Zhang, Ming Zhang   +10 more
doaj   +1 more source

C-Reactive Protein/Albumin Ratio Correlates With Disease Severity and Predicts Outcome in Patients With Aneurysmal Subarachnoid Hemorrhage

Frontiers in Neurology, 2019
Aim: The purpose of the present study was to determine if C-reactive protein (CRP)/albumin ratio was associated with disease severity and unfavorable outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH).Methods: One hundred and twenty-three
Dingding Zhang, Huiying Yan, Yongxiang Wei, Xiangyu Liu, Zong Zhuang, Wei Dai, Jinsong Li, Wei Li, Chunhua Hang   +8 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Decision-making in wildlife forensics: comparing complex and simple cases at the Wyoming Game and Fish Laboratory

Frontiers in Ecology and Evolution
This study compares the decision-making processes and workflows of complex and simple wildlife forensic cases at the Wyoming Game and Fish Wildlife Forensic Laboratory.
Kimberly M. Frazier, Tasha L. Bauman
doaj   +1 more source

Serum Free Light Chains Removal by HFR Hemodiafiltration in Patients with Multiple Myeloma and Acute Kidney Injury. a Case Series [PDF]

, 2018
Background/Aims: Multiple myeloma (MM) represents 10% of all haematologic malignancies. Renal involvement occurs in 50% of MM patients; of them, 12-20% have acute kidney injury (AKI), with 10% needing dialysis at presentation. While hemodialysis (HD) has
Antolino, Giusy, Festuccia, Francescaromana, Fofi, Claudia, Giammarioli, Elisa, La Verde, Giacinto, Mene, Paolo, Punzo, Giorgio, Tafuri, Agostino   +7 more
core   +2 more sources

Novel Pectin/Chia-Mucilage Membranes: Human Serum Albumin Adsorption, Biocompatibility, and Physical-Chemical Properties [PDF]

, 2023
S. E. Burruel-Ibarra, R. A. Esquer-Osuna, Ramón Gertrudis Valdez-Melchor, D. A. Cuevas-Acu馻, L. QuihuiCota, J. Ju醨ez, J. C. Campos-Garc韆, Edith Valbuena‐Gregorio, M. A. L髉ez-Mata   +8 more
openalex   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Changes in blood serum protein profile in low-yielding ewes during the periparturient period

Open Veterinary Journal
Background: In high-yielding dairy ewes, metabolic and reproductive processes occurring around the time of parturition and during lactation initiation are accompanied by several changes in blood biochemical parameters, including those related to protein
Veronika Glembova, Csilla Tóthova, Veronika Oršuľakova, Oskar Nagy   +3 more
doaj   +1 more source