Results 71 to 80 of about 1,110,362 (306)

Predictive value of serum uric acid-to-albumin ratio for diabetic kidney disease in patients with type 2 diabetes mellitus: a case-control study

Frontiers in Endocrinology
ObjectiveThe aim of this study was to investigate the predictive effects of the serum uric acid-to-albumin ratio (sUAR) on the onset of diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM).MethodsA case-control study was ...
Jing Du, Xiumei Xu, Ning Yuan, Xiaomei Zhang   +3 more
doaj   +1 more source

Albumin-Oxanorbornadiene Conjugates Formed ex Vivo for the Extended Circulation of Hydrophilic Cargo

, 2016
Oxanorbornadiene dicarboxylate (OND) reagents were explored for the purpose of binding and releasing chemical cargos from endogenous circulating serum albumins.
M.G. Finn (1507627), Marsha R. Eno (2853983), Cody J. Higginson (1332081), Susan Khan (1332243), Michael D. Cameron (1436593)   +4 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

A Comprehensive Immunocapture-LC-MS/MS Bioanalytical Approach in Support of a Biotherapeutic Ocular PK Study

Pharmaceuticals
BI-X, a therapeutic protein under development for the treatment of human ocular disease via intravitreal administration, binds to its therapeutic targets and endogenous albumin in the vitreous humor.
Lin-Zhi Chen, David Roos, Elsy Philip, Emily G. Werth, Stephanie Kostuk, Hongbin Yu, Holger Fuchs   +6 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

GP60 and SPARC as albumin receptors: key targeted sites for the delivery of antitumor drugs

Frontiers in Pharmacology
Albumin is derived from human or animal blood, and its ability to bind to a large number of endogenous or exogenous biomolecules makes it an ideal drug carrier. As a result, albumin-based drug delivery systems are increasingly being studied.
Qingzhi Ji, Huimin Zhu, Yuting Qin, Ruiya Zhang, Lei Wang, Erhao Zhang, Xiaorong Zhou, Run Meng   +7 more
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Albumin-drug interaction and its clinical implication

, 2013
Background: Human serum albumin acts as a reservoir and transport protein for endogenous (e.g. fatty acids or bilirubin) and exogenous compounds (e.g. drugs or nutrients) in the blood.
K. Yamasaki (12131984), Victor Chuang (23310466), M. Otagiri (23318917), T. Maruyama (23318914)   +3 more
core  

The effects of age on associations between markers of HIV progression and markers of metabolic function including albumin, haemoglobin and lipid concentrations. [PDF]

, 2013
We investigated whether age modified associations between markers of HIV progression, CD4 T lymphocyte count and HIV RNA viral load (VL), and the following markers of metabolic function: albumin, haemoglobin, high-density lipoprotein cholesterol (HDL-C),
C Leen, Samuel, M., Chadwick, D, Gompels, Mark, Johnson, M., Anderson, Jane, Leen, Clifford, Samuel, M, Fisher, M., Pillay, Deenan, Orkin, Chloe, Sabin, C, Hay, Phillip, Johnson, M, CA Sabin, M Fisher, Nelson, M., M Johnson, S Jose, Gilson, Richard, Fisher, M, Ainsworth, Jonathan, ?, ?, Johnson, Margaret, Gilson, R, Sabin, C. A., Hay, P, D Chadwick, Gompels, M, R Gilson, Sabin, Ca, Nelson, Mark, UK Collaborative HIV Cohort Study, Palfreeman, Adrian, P Hay, Delpech, Valerie, Fisher, Martin, FA Post, Babiker, Abdel, UK Collaborative HIV Cohort Study (UK CHIC), Chadwick, David, Hay, P., Kegg, Stephen, M Samuel, Gilson, R., Gompels, M., Sachikonye, Memory, Nelson, M, Winston, A, Post, Fa, A Winston, Leen, C., Gazzard, Brian, Post, F A, Jose, S., Post, Frank, M Nelson, Jose, S, Post, F, Chadwick, D., Sabin, C A, Leen, C, Winston, A., M Gompels   +63 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source