Results 71 to 80 of about 1,084,443 (309)

Predictive value of serum uric acid-to-albumin ratio for diabetic kidney disease in patients with type 2 diabetes mellitus: a case-control study

Frontiers in Endocrinology
ObjectiveThe aim of this study was to investigate the predictive effects of the serum uric acid-to-albumin ratio (sUAR) on the onset of diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM).MethodsA case-control study was ...
Jing Du, Xiumei Xu, Ning Yuan, Xiaomei Zhang   +3 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

A Comprehensive Immunocapture-LC-MS/MS Bioanalytical Approach in Support of a Biotherapeutic Ocular PK Study

Pharmaceuticals
BI-X, a therapeutic protein under development for the treatment of human ocular disease via intravitreal administration, binds to its therapeutic targets and endogenous albumin in the vitreous humor.
Lin-Zhi Chen, David Roos, Elsy Philip, Emily G. Werth, Stephanie Kostuk, Hongbin Yu, Holger Fuchs   +6 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

GP60 and SPARC as albumin receptors: key targeted sites for the delivery of antitumor drugs

Frontiers in Pharmacology
Albumin is derived from human or animal blood, and its ability to bind to a large number of endogenous or exogenous biomolecules makes it an ideal drug carrier. As a result, albumin-based drug delivery systems are increasingly being studied.
Qingzhi Ji, Huimin Zhu, Yuting Qin, Ruiya Zhang, Lei Wang, Erhao Zhang, Xiaorong Zhou, Run Meng   +7 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Albumin-Modified Cationic Nanocarriers To Potentially Create a New Platform for Drug Delivery Systems

, 2019
Cationic nanocarriers have emerged as promising nanoparticle systems for the effective delivery of nucleic acid and anticancer drugs to cancer cells. A positive charge is desirable for promoting cell internalization, whereas it also causes some adverse ...
Danxuan Fang, Jiehua Li, Nijia Song, Hong Tan (472478), Xueling He (1768213), Zhicheng Pan (1991122), Feng Luo (47640), Zhicheng Pan, Feng Luo, Zhen Li (49109), Zhen Li, Danxuan Fang (3628328), Jianshu Li (1432297), Jianshu Li, Xueling He, Qiang Fu (129583), Hong Tan, Jiehua Li (472477), Qiang Fu, Nijia Song (1978036)   +19 more
core   +1 more source

Early Albumin Exposure After Cardiac Surgery

, 2021
OBJECTIVES: To determine whether the early use of albumin after cardiac surgery in the first 24 hours in the intensive care unit (ICU) is associated with reduced mortality.
Ramanan, Mahesh, Thang, Christopher, Kumar, Aashish, Marella, Prashanti, Matebele, Mbakise   +4 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Albumin-Oxanorbornadiene Conjugates Formed ex Vivo for the Extended Circulation of Hydrophilic Cargo

, 2016
Oxanorbornadiene dicarboxylate (OND) reagents were explored for the purpose of binding and releasing chemical cargos from endogenous circulating serum albumins.
M.G. Finn (1507627), Marsha R. Eno (2853983), Cody J. Higginson (1332081), Susan Khan (1332243), Michael D. Cameron (1436593)   +4 more
core   +1 more source