Results 11 to 20 of about 322,342 (333)
Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source
Frontiers in Psychiatry, 2019 Opioid use in the United States has steadily risen since the 1990s, along with staggering increases in addiction and overdose fatalities. With this surge in prescription and illicit opioid abuse, it is paramount to understand the genetic risk factors and
Jamie A. Burns +8 more
doaj +1 more source
Frontiers in Psychiatry, 2023 BackgroundFear of COVID-19 is a risk factor for anxiety and depressive symptoms. During the COVID-19 pandemic, drinking to cope with psychological distress has been proposed as a key mechanism leading to problematic drinking.
Jeremy W. Luk +8 more
doaj +1 more source
Platelet monoamine oxidase activity in alcoholics with and without a family history of alcoholism [PDF]
, 2000 A number of studies point at platelet monoamine oxidase (MAO) activity being reduced in alcoholics with a family history of drinking, this being a possible vulnerability marker for alcoholism.
Benda, Ellen +5 more
core +1 more source
Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
Journal of Neuroinflammation, 2023 Background Neuroinflammation is a widely studied phenomenon underlying various neurodegenerative diseases. Earlier study demonstrated that pharmacological activation of GPR110 in both central and peripheral immune cells cooperatively ameliorates ...
Sharmistha Banerjee +3 more
doaj +1 more source
Increased transcription of TSPO, HDAC2, and HDAC6 in the amygdala of males with alcohol use disorder
Brain and Behavior, 2021 Introduction Repeated exposure to high doses of alcohol triggers neuroinflammatory processes that contribute to craving and mood dysfunction in alcohol use disorder (AUD).
Luana Martins De Carvalho +4 more
doaj +1 more source
The Journal of Nervous and Mental Disease, 1875 Alcohol affects brain activity in various ways. It has both short-term and long-term effects. It causes slurred speech, short-term memory dysfunctions hallucinations, etc. by timing the activity of neuronal cells. Moreover, it causes teratogenic effects in the fetus ifthe mother is consuming alcohol during pregnancy. Alcohol can damage the brain cells,
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Molecules, 2021 Alcohol consumption is associated with gut dysbiosis, increased intestinal permeability, endotoxemia, and a cascade that leads to persistent systemic inflammation, alcoholic liver disease, and other ailments.
Luis Santos-Molina +10 more
doaj +1 more source
BMJ, 1982 Abstract There is evidence for a dose-response relationship between alcohol consumption and risk of liver cirrhosis, cancers of the oropharynx, larynx, oesophagus, rectum (beer only), liver, and female breast, and violent death, but the relationship between alcohol consumption and cardiovascular disease is more complex.
openaire +2 more sources