Results 11 to 20 of about 104,488 (209)

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

A Girls’ Army of Vengeance?: Perceptions of Sexual Violence against Children in post‐1905 Russia

Gender &History, EarlyView., 2023
Abstract This article offers a microhistorical reading of a criminal case of sexual violence in 1908 St Petersburg. It traces the re‐interpretation of underage girls from innocent victims to potential prostitutes and carriers of debauchery and disease.
Alexandra Oberländer
wiley   +1 more source

Return Fantasies: Martial Masculinity, Misogyny and Homosocial Bonding in the Aftermath of Second World War

Gender &History, EarlyView., 2023
Abstract This article explores male popular culture in Australia in the mid‐1940s, particularly men's magazines of the period, to illuminate aspects of the psycho‐sexual dimensions of Australian veterans returning to civil society. The sexual landscape of Australian society had undergone considerable transformation, especially through an increasing ...
Stephen Garton
wiley   +1 more source

A Tale of Two Annies: Historical Memory, Archives and the Perpetuation of the Sinners to Angels Trope in American Sex Worker History

Gender &History, EarlyView., 2023
Abstract As a historian of sex work, I analyse the power dynamics in the archiving practices and interpretation of sex worker lives, deconstructing the historic and current discourses shaping the possibilities for sex workers. In this article, I explore the legends of nineteenth‐century Madams Annie Cook and Annie Chambers.
Ashley Barnes‐Gilbert
wiley   +1 more source

Care Leavers Into Parenthood: Support Needs and Effective Practice Approaches Through Transitions From Care

Australian Journal of Social Issues, EarlyView.
ABSTRACT There is significant local and international evidence to show that young people transitioning from care have children by age 21 at far higher rates than the general youth population. Intergenerational child protection involvement is also far higher for this group.
Jade Purtell, Sarah Morris
wiley   +1 more source

Effects of Dictyophora polysaccharide on cerebellar Purkinje cell degeneration in a chronic alcohol mouse model

Animal Models and Experimental Medicine, EarlyView.
In an ethanol (EtOH)‐treated mouse model, increases in the NLRP3 inflammasome proteins, PC degeneration, and motor coordination disorders were observed. DIP suppressed the NLRP3‐ASC‐caspase‐1 signaling pathway, and alleviated the motor deficits and cerebellar pathological changes in chronic EtOH‐treated mice.
Jian Zhang, Zhihui Dai, Huanhuan Yu, Baofei Sun, Jiuyang Ding, Yuanhe Wang   +5 more
wiley   +1 more source

GDF10 Regulates Iron‐Dependent Lipid Oxidation in Colorectal Cancer Cells Through Interaction With IGF2

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Background: This study aims to identify genes with a high likelihood of genetic variation, significant expression differences, and prognostic implications in colorectal cancer (CRC) patients. The research also seeks to investigate the role and mechanisms of key genes in CRC through the analysis of health information data and a combination of ...
Kaobin Ouyang, Tianying Huang, Dan Xie, Hailin Xiong   +3 more
wiley   +1 more source

Safety, tolerability, pharmacokinetics and pharmacodynamics of HSK31858, a novel oral dipeptidyl peptidase‐1 inhibitor, in healthy volunteers: An integrated phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Dipeptidyl peptidase‐1 (DPP‐1) inhibitors have been studied for the treatment of neutrophil‐mediated inflammatory diseases including bronchiectasis, bronchial asthma and cystic fibrosis. This study evaluated the pharmacokinetics, pharmacodynamics, safety and tolerability of DPP‐1 inhibitor HSK31858 in healthy Chinese volunteers.
Yuhao Wang, Chao Yu, Mengyue Hu, Lu Wang, Meixia Chen, Hanmo Liu, Nan Wu, Jie Hou   +7 more
wiley   +1 more source

Perceived Security, Confidence in the Police and Subjective Well‐Being in Hong Kong: Evidence from the World Values Survey

Behavioral Sciences &the Law, EarlyView.
ABSTRACT The legitimacy of the Hong Kong police has somewhat plummeted amid the Umbrella Movement in 2014 and the Pro‐Democracy Movement in 2019. This study aims to explore the dynamics among Hong Kongers' perception of security, confidence in the police, and their subjective well‐being using the Wave 7 (2017–2022) of the World Values Survey (WVS‐7 ...
Melody W. S. Ip, Heng Choon (Oliver) Chan   +1 more
wiley   +1 more source