Results 21 to 30 of about 325,826 (332)

4288 Identifying Predictive Variables of High-Intensity Binge Drinking Through the Use of a Machine Learning Algorithm

open access: yesJournal of Clinical and Translational Science, 2020
OBJECTIVES/GOALS: To test if a machine learning algorithm could predict a person’s capacity to binge drink and explore what measures might be important for identifying individuals at risk for high-intensity binge drinking behaviors.
James Keoni Morris   +4 more
doaj   +1 more source

Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia

open access: yesMolecules, 2021
Alcohol consumption is associated with gut dysbiosis, increased intestinal permeability, endotoxemia, and a cascade that leads to persistent systemic inflammation, alcoholic liver disease, and other ailments.
Luis Santos-Molina   +10 more
doaj   +1 more source

Socioeconomic status, BMI, and brain development in children

open access: yesTranslational Psychiatry, 2022
Low socioeconomic status (SES) in childhood is associated with deficits in executive function and changes in cortical morphology. Furthermore, rates of childhood obesity are greater among low SES children and childhood obesity is also associated with ...
Evan Dennis, Peter Manza, Nora D. Volkow
doaj   +1 more source

A brief history of research on the genetics of alcohol and other drug use disorders. [PDF]

open access: yes, 2014
ObjectiveThis article reviews developments in research on genetic influences on alcohol and other drug use and disorders over the past 7 decades.MethodThe author began with a review of the flow and content of articles published in the three iterations of
Schuckit, Marc A
core   +2 more sources

Correspondence between cerebral glucose metabolism and BOLD reveals relative power and cost in human brain

open access: yesNature Communications, 2019
The brain primarily uses glucose to generate energy, but the relationship of neuronal activity to glucose utilization is not necessarily a simple linear one.
Ehsan Shokri-Kojori   +5 more
doaj   +1 more source

Endocannabinoid-dopamine interactions in striatal synaptic plasticity

open access: yesFrontiers in Pharmacology, 2012
The nigrostriatal dopaminergic system is implicated in action control and learning. A large body of work has focused on the contribution of this system to modulation of the corticostriatal synapse, the predominant synapse type in the striatum ...
Brian Neil Mathur, David M Lovinger
doaj   +1 more source

Empathy [PDF]

open access: yes, 2017
A short poem about suicidal ideation and alcoholism in the United ...
Golomski, Casey
core   +2 more sources

Peripheral Hybrid CB1R and iNOS Antagonist MRI-1867 Displays Anti-Fibrotic Efficacy in Bleomycin-Induced Skin Fibrosis

open access: yesFrontiers in Endocrinology, 2021
Scleroderma, or systemic sclerosis, is a multi-organ connective tissue disease resulting in fibrosis of the skin, heart, and lungs with no effective treatment. Endocannabinoids acting via cannabinoid-1 receptors (CB1R) and increased activity of inducible
Charles N. Zawatsky   +8 more
doaj   +1 more source

Flupenthixol in relapse prevention in schizophrenics with comorbid alcoholism: Results from an open clinical study [PDF]

open access: yes, 2003
Substance use, especially alcoholism, has been recognized as a significant problem in schizophrenic patients, though only a few studies on the effects of pharmacotherapy in these patients have been conducted so far.
Aichmüller, Claus   +6 more
core   +1 more source

Multi-omic underpinnings of epigenetic aging and human longevity

open access: yesNature Communications, 2023
Biological aging is accompanied by increasing morbidity, mortality, and healthcare costs; however, its molecular mechanisms are poorly understood. Here, we use multi-omic methods to integrate genomic, transcriptomic, and metabolomic data and identify ...
Lucas A. Mavromatis   +5 more
doaj   +1 more source

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