Results 21 to 30 of about 387,405 (380)

Multidimensional Quality of Life Across the Spectrum of Alcohol Use Behavior

Psychiatric Research and Clinical Practice, 2022
Objective Quality of life (QoL) is inversely associated with alcohol misuse and is a key measure by which recovery from alcohol use disorder (AUD) might be assessed. Yet, the determinants of QoL are scarcely known. The authors examined three ways through
Jeremy W. Luk, Vijay A. Ramchandani, Nancy Diazgranados, Melanie L. Schwandt, Tommy Gunawan, David T. George, David Goldman   +6 more
doaj   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

The endocannabinoid system promotes hepatocyte progenitor cell proliferation and maturation by modulating cellular energetics

Cell Death Discovery, 2023
The proliferation and differentiation of hepatic progenitor cells (HPCs) drive the homeostatic renewal of the liver under diverse conditions. Liver regeneration is associated with an increase in Axin2+Cnr1+ HPCs, along with a marked increase in the ...
Bani Mukhopadhyay, Kellie Holovac, Kornel Schuebel, Partha Mukhopadhyay, Resat Cinar, Sindhu Iyer, Cheryl Marietta, David Goldman, George Kunos   +8 more
doaj   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Sleep disturbances are associated with cortical and subcortical atrophy in alcohol use disorder

Translational Psychiatry, 2021
Sleep disturbances are prominent in patients with alcohol use disorder (AUD) and predict relapse. So far, the mechanisms underlying sleep disruptions in AUD are poorly understood.
Rui Zhang, Dardo Tomasi, Peter Manza, Ehsan Shokri-Kojori, Sukru B. Demiral, Dana E. Feldman, Danielle S. Kroll, Catherine L. Biesecker, Katherine L. McPherson, Gene-Jack Wang, Corinde E. Wiers, Nora D. Volkow   +11 more
doaj   +1 more source

Molecular Imaging of Opioid and Dopamine Systems: Insights Into the Pharmacogenetics of Opioid Use Disorders

Frontiers in Psychiatry, 2019
Opioid use in the United States has steadily risen since the 1990s, along with staggering increases in addiction and overdose fatalities. With this surge in prescription and illicit opioid abuse, it is paramount to understand the genetic risk factors and
Jamie A. Burns, Danielle S. Kroll, Dana E. Feldman, Christopher Kure Liu, Peter Manza, Corinde E. Wiers, Nora D. Volkow, Nora D. Volkow, Gene-Jack Wang   +8 more
doaj   +1 more source

Platelet monoamine oxidase activity in alcoholics with and without a family history of alcoholism [PDF]

, 2000
A number of studies point at platelet monoamine oxidase (MAO) activity being reduced in alcoholics with a family history of drinking, this being a possible vulnerability marker for alcoholism.
Benda, Ellen, Bondy, Brigitta, Hegerl, Ulrich, Möller, Hans-Jürgen, Preuss, Ulrich W., Soyka, Michael   +5 more
core   +1 more source

Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation

Journal of Neuroinflammation, 2023
Background Neuroinflammation is a widely studied phenomenon underlying various neurodegenerative diseases. Earlier study demonstrated that pharmacological activation of GPR110 in both central and peripheral immune cells cooperatively ameliorates ...
Sharmistha Banerjee, Taeyeop Park, Yoo Sun Kim, Hee-Yong Kim   +3 more
doaj   +1 more source

Social media addiction as a mediator of the associations between fear of COVID-19, mental health symptoms, and problematic alcohol use

Frontiers in Psychiatry, 2023
BackgroundFear of COVID-19 is a risk factor for anxiety and depressive symptoms. During the COVID-19 pandemic, drinking to cope with psychological distress has been proposed as a key mechanism leading to problematic drinking.
Jeremy W. Luk, Daniel W. Geda, Bethany L. Stangl, Cecilia Cheng, Melanie L. Schwandt, David Goldman, David Goldman, Nancy Diazgranados, Vijay A. Ramchandani   +8 more
doaj   +1 more source

Alcoholism Identification Based on an AlexNet Transfer Learning Model

Frontiers in Psychiatry, 2019
Aim: This paper proposes a novel alcoholism identification approach that can assist radiologists in patient diagnosis. Method: AlexNet was used as the basic transfer learning model.
Shui-hua Wang, Shipeng Xie, Xianqing Chen, D. Guttery, Chaosheng Tang, Junding Sun, Yudong Zhang   +6 more
semanticscholar   +1 more source