Results 41 to 50 of about 136,151 (292)

Investigation of [11C]carfentanil for mu opioid receptor quantification in the rat brain

Scientific Reports
[11C]Carfentanil ([11C]CFN) is the only selective carbon-11 labeled radiotracer currently available for positron emission tomography (PET) imaging of mu opioid receptors (MORs).
Andrew C. Kelleher, Torben D. Pearson, Joseph Ramsey, Wenjing Zhao, Kelly A. O’Conor, Abolghasem Bakhoda, Tyler Stodden, Min Guo, Seth M. Eisenberg, Sarthak V. Shah, Michael L. Freaney, Woochan Kim, Yeona Kang, Dardo Tomasi, Christopher Johnson, Chung-An Fang, Nora D. Volkow, Sung Won Kim   +17 more
doaj   +1 more source

Sex‐specific elevated incidence of glaucoma associated with topiramate versus valproate or lamotrigine in epilepsy, not migraine: A population‐based cohort study

Epilepsia, EarlyView.
Abstract Objective Topiramate has been linked to increased glaucoma risk, potentially through mechanisms involving ocular fluid shifts. However, comparative risks vs other antiseizure medications (ASMs) and variation by sex or indication remain uncertain.
Cuiling Wei, Rachel Yui Ki Chu, Rachel Lancey Lai, Florinda Hui‐Ning Chu, Ian Yu Hin Leung, William Chun Yin Leung, Franco Wing Tak Cheng, Thomas Chi Ho Lam, Ian Chi Kei Wong, Esther Wai Yin Chan, Francisco Tsz Tsun Lai   +10 more
wiley   +1 more source

A simple, highly efficient method for heterologous expression in mammalian primary neurons using cationic lipid-mediated mRNA transfection

Frontiers in Neuroscience, 2010
Expression of heterologous proteins in adult mammalian neurons is a valuable technique for the study of neuronal function. The postmitotic nature of mature neurons prevents effective DNA transfection using simple, cationic lipid-based methods.
Damian J Williams, Henry L Puhl, Stephen R Ikeda   +2 more
doaj   +1 more source

Addressing Heterogeneity in Binge Eating Disorder: A Cluster Analysis Approach Based on Age of Onset, Clinical and Psychopathological Features

European Eating Disorders Review, EarlyView.
ABSTRACT Objective This study investigates clinical heterogeneity in patients with binge eating disorder (BED) and its association with treatment outcomes. Methods A two‐step cluster analysis was conducted on a clinical sample of 196 BED patients, using an agglomerative hierarchical procedure based on both categorical and quantitative measures ...
Lucía Camacho‐Barcia, Lia T. Sánchez‐Salido, Jessica Jiménez del Toro, Roser Granero, Isabel Sánchez, Kim Supit, Nadia Micali, Katrin Elisabeth Giel, Susana Jiménez‐Murcia, Stephan Zipfel, Fernando Fernández‐Aranda   +10 more
wiley   +1 more source

Longitudinal gut microbiome changes in alcohol use disorder are influenced by abstinence and drinking quantity

Gut Microbes, 2020
Many patients with alcohol use disorder (AUD) consume alcohol chronically and in large amounts that alter intestinal microbiota, damage the gastrointestinal tract, and thereby injure other organs via malabsorption and intestinal inflammation.
Nancy J. Ames, Jennifer J. Barb, Kornel Schuebel, Sarah Mudra, Brianna K. Meeks, Ralph Thadeus S. Tuason, Alyssa T. Brooks, Narjis Kazmi, Shanna Yang, Kelly Ratteree, Nancy Diazgranados, Michael Krumlauf, Gwenyth R. Wallen, David Goldman   +13 more
doaj   +1 more source

Brain asymmetry and its association with inattention and heritability during neurodevelopment

Translational Psychiatry
The relationship between brain asymmetry and inattention, and their heritability is not well understood. Utilizing advanced neuroimaging, we examined brain asymmetry with data from the Adolescent Brain Cognitive Development (ABCD; n = 8943; 9–10 y) and ...
Dardo Tomasi, Nora D. Volkow
doaj   +1 more source

Predicting 7‐year‐olds mental health in the perinatal period: Development and internal validation of a multivariable model using the prospective ALSPAC cohort

JCPP Advances, EarlyView.
Abstract Background Mental health difficulties in childhood are increasing. Prevention is the only sustainable and ethical public health approach. However, predicting which children are most at‐risk of mental health difficulties prior to symptoms emerging remains elusive.
Emma Butler, Michelle Spirtos, Linda M. O’Keeffe, Mary Clarke   +3 more
wiley   +1 more source

Gestational alcohol exposure disrupts cognitive function and striatal circuits in adult offspring

Nature Communications, 2020
Alcohol is the leading cause of preventable birth defects in the US, collectively referred to as Fetal Alcohol Spectrum Disorder. Here, the authors show that fetal alcohol exposure induces lasting neurophysiological changes in dorsal striatum that ...
Verginia C. Cuzon Carlson, Christina M. Gremel, David M. Lovinger   +2 more
doaj   +1 more source

Commentary: Three questions for the study of traumatic brain injury in animals

The Anatomical Record, EarlyView.
Gregory Hollin
wiley   +1 more source

Difficulties and Feelings Experienced by Undergraduate Dental Students When Caring for Patients

Journal of Dental Education, EarlyView.
ABSTRACT Purpose Dealing with the patient's illness process is part of the academic trajectory of healthcare students. The relationship between patients and their healthcare professionals can be complex and challenging, especially for undergraduate dental students. The purpose of this study was to evaluate the perceptions, feelings, and difficulties of
Bruna B. Rodrigues, Ana L. Santos‐Sousa, Tamara F. Castro, Vitor B. Valente, Glauco I. Miyahara, Daniel G. Bernabé   +5 more
wiley   +1 more source