Results 41 to 50 of about 387,405 (380)
Flupenthixol in relapse prevention in schizophrenics with comorbid alcoholism: Results from an open clinical study [PDF]
, 2003 Substance use, especially alcoholism, has been recognized as a significant problem in schizophrenic patients, though only a few studies on the effects of pharmacotherapy in these patients have been conducted so far.
Aichmüller, Claus +6 more
core +1 more source
Endocannabinoid-dopamine interactions in striatal synaptic plasticity
Frontiers in Pharmacology, 2012 The nigrostriatal dopaminergic system is implicated in action control and learning. A large body of work has focused on the contribution of this system to modulation of the corticostriatal synapse, the predominant synapse type in the striatum ...
Brian Neil Mathur, David M Lovinger
doaj +1 more source
Alcoholism: a systemic proinflammatory condition.
World Journal of Gastroenterology, 2014 Excessive ethanol consumption affects virtually any organ, both by indirect and direct mechanisms. Considerable research in the last two decades has widened the knowledge about the paramount importance of proinflammatory cytokines and oxidative damage in
E. González‐Reimers +4 more
semanticscholar +1 more source
Multi-omic underpinnings of epigenetic aging and human longevity
Nature Communications, 2023 Biological aging is accompanied by increasing morbidity, mortality, and healthcare costs; however, its molecular mechanisms are poorly understood. Here, we use multi-omic methods to integrate genomic, transcriptomic, and metabolomic data and identify ...
Lucas A. Mavromatis +5 more
doaj +1 more source
Frontiers in Endocrinology, 2021 Scleroderma, or systemic sclerosis, is a multi-organ connective tissue disease resulting in fibrosis of the skin, heart, and lungs with no effective treatment. Endocannabinoids acting via cannabinoid-1 receptors (CB1R) and increased activity of inducible
Charles N. Zawatsky +8 more
doaj +1 more source
MONOAMINE OXIDASE A (MAOA), CHILDHOOD TRAUMA, ALCOHOLISM AND AGGRESSION [PDF]
, 2008 Women who have experienced childhood sexual abuse (CSA) have an increased risk of alcoholism and antisocial personality disorder (ASPD). Among males, a functional polymorphism (MAOA-LPR, monoamine oxidase A linked polymorphic region) in the promoter ...
DUCCI, FRANCESCA
core
A brief history of research on the genetics of alcohol and other drug use disorders. [PDF]
, 2014 ObjectiveThis article reviews developments in research on genetic influences on alcohol and other drug use and disorders over the past 7 decades.MethodThe author began with a review of the flow and content of articles published in the three iterations of
Schuckit, Marc A
core +2 more sources
Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels
Advanced Science, EarlyView.A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu +10 more
wiley +1 more source
GPR110 (ADGRF1) mediates anti-inflammatory effects of N-docosahexaenoylethanolamine
Journal of Neuroinflammation, 2019 Background Neuroinflammation is a widely accepted underlying condition for various pathological processes in the brain. In a recent study, synaptamide, an endogenous metabolite derived from docosahexaenoic acid (DHA, 22:6n-3), was identified as a ...
Taeyeop Park, Huazhen Chen, Hee-Yong Kim
doaj +1 more source
A Long-Term Study of Sons of Alcoholics. [PDF]
, 1995 Men with a family history of alcoholism appear to have a lower intensity reaction to alcohol's effects than those without this family history. This study investigated whether a lower reaction could encourage greater alcohol consumption among family ...
Schuckit, Marc A
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