Results 51 to 60 of about 136,710 (292)

‘The System Can't Cope’: The Service System Response to Alcohol and Other Drug‐Facilitated Sexual Violence

Australian Journal of Social Issues, EarlyView.
ABSTRACT Alcohol and other drug‐facilitated sexual violence can have significant impacts on victim‐survivors, yet little is known about what support service providers offer them. To understand the experiences and perceptions of service providers, interviews with counsellors, health workers, forensic toxicologists and harm reduction workers were ...
Jessica Ison, Jacqui Theobald, Kirsty Forsdike, Ingrid Wilson, Elena Wilson, Leesa Hooker   +5 more
wiley   +1 more source

Investigation of [11C]carfentanil for mu opioid receptor quantification in the rat brain

Scientific Reports
[11C]Carfentanil ([11C]CFN) is the only selective carbon-11 labeled radiotracer currently available for positron emission tomography (PET) imaging of mu opioid receptors (MORs).
Andrew C. Kelleher, Torben D. Pearson, Joseph Ramsey, Wenjing Zhao, Kelly A. O’Conor, Abolghasem Bakhoda, Tyler Stodden, Min Guo, Seth M. Eisenberg, Sarthak V. Shah, Michael L. Freaney, Woochan Kim, Yeona Kang, Dardo Tomasi, Christopher Johnson, Chung-An Fang, Nora D. Volkow, Sung Won Kim   +17 more
doaj   +1 more source

Annotating aspects in text and image: A new task and dataset for multimodal aspect‐based sentiment analysis

Journal of the Association for Information Science and Technology, EarlyView.
Abstract Aspect‐Based Sentiment Analysis (ABSA) has evolved from textual analysis to a multimodal paradigm, integrating visual information to capture nuanced sentiments. Despite advancements, existing Multimodal ABSA (MABSA) research remains limited in granularity, which focuses on either coarse‐level categories or named entities, neglecting fine ...
Li Yang, Jia Yang, Jin‐Cheon Na, Jianfei Yu   +3 more
wiley   +1 more source

A simple, highly efficient method for heterologous expression in mammalian primary neurons using cationic lipid-mediated mRNA transfection

Frontiers in Neuroscience, 2010
Expression of heterologous proteins in adult mammalian neurons is a valuable technique for the study of neuronal function. The postmitotic nature of mature neurons prevents effective DNA transfection using simple, cationic lipid-based methods.
Damian J Williams, Henry L Puhl, Stephen R Ikeda   +2 more
doaj   +1 more source

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse

British Journal of Clinical Pharmacology, EarlyView.
Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia, Huang Xingxing, Jin Lu, Wang Ruwei   +3 more
wiley   +1 more source

Longitudinal gut microbiome changes in alcohol use disorder are influenced by abstinence and drinking quantity

Gut Microbes, 2020
Many patients with alcohol use disorder (AUD) consume alcohol chronically and in large amounts that alter intestinal microbiota, damage the gastrointestinal tract, and thereby injure other organs via malabsorption and intestinal inflammation.
Nancy J. Ames, Jennifer J. Barb, Kornel Schuebel, Sarah Mudra, Brianna K. Meeks, Ralph Thadeus S. Tuason, Alyssa T. Brooks, Narjis Kazmi, Shanna Yang, Kelly Ratteree, Nancy Diazgranados, Michael Krumlauf, Gwenyth R. Wallen, David Goldman   +13 more
doaj   +1 more source

Unveiling Bias: The Impact of Male Rape Myths and Stereotypes on Juror Verdicts in Male‐on‐Male Rape Trials

Behavioral Sciences &the Law, EarlyView.
ABSTRACT This study examined how male rape myths, racial/ethnicity biases, and sexuality stereotypes influence verdicts in male‐on‐male rape trials—an area that is currently under‐researched. A sample of 463 participants read a mock rape trial, where both the defendant and complainant were male, with defendant ethnicity (White, Black, Asian) and ...
Lee J. Curley, B. Kennath Widanaralalage, Dominic Willmott, Joanna Ermenkova   +3 more
wiley   +1 more source

Brain asymmetry and its association with inattention and heritability during neurodevelopment

Translational Psychiatry
The relationship between brain asymmetry and inattention, and their heritability is not well understood. Utilizing advanced neuroimaging, we examined brain asymmetry with data from the Adolescent Brain Cognitive Development (ABCD; n = 8943; 9–10 y) and ...
Dardo Tomasi, Nora D. Volkow
doaj   +1 more source

Gestational alcohol exposure disrupts cognitive function and striatal circuits in adult offspring

Nature Communications, 2020
Alcohol is the leading cause of preventable birth defects in the US, collectively referred to as Fetal Alcohol Spectrum Disorder. Here, the authors show that fetal alcohol exposure induces lasting neurophysiological changes in dorsal striatum that ...
Verginia C. Cuzon Carlson, Christina M. Gremel, David M. Lovinger   +2 more
doaj   +1 more source

Naloxone precipitated withdrawal increases dopamine release in the dorsal striatum of opioid dependent men

Translational Psychiatry, 2021
Dopamine (DA) neurotransmission is critical in the neurobiology of reward and aversion, but its contribution to the aversive state of opioid withdrawal remains unknown in humans.
Ehsan Shokri-Kojori, Gene-Jack Wang, Nora D. Volkow   +2 more
doaj   +1 more source