Results 51 to 60 of about 104,488 (209)
Examining the predictive validity of alcohol‐seeking following punishment‐imposed abstinence in mice
Alcohol, Clinical and Experimental Research, EarlyView.Animal models of alcohol use disorder are critical to understand the neurochemical mechanisms underlying this disorder to inform targeted medication development. However, quite often the validity of commonly used animal models remains untested. Here, we optimized a highly used model of abstinence in mice and demonstrated the predictive validity of the ...
Linh Tran +3 more
wiley +1 more source
Stress and episodic future thinking: Effects on temporal window and alcohol demand
Alcohol, Clinical and Experimental Research, EarlyView.Theories suggest stress increases alcohol use by inducing short‐term thinking. Episodic future thinking (EFT), which involves vividly imagining future events to reduce short‐term thinking, may help break the stress–alcohol link. We tested whether EFT was particularly effective at reducing desire for alcohol for people under greater stress.
Jennifer K. Hoots, Margaret C. Wardle
wiley +1 more source
Alcohol Problems. ABC of Alcohol. Alcohol and Alcoholism [PDF]
Postgraduate Medical Journal, 1983 openaire +2 more sources
Alcohol, Clinical and Experimental Research, EarlyView.Adopted adolescents with reported fetal alcohol spectrum disorder (FASD) showed significant impairments in psychosocial adjustment, neurocognitive function, and head circumference compared to adopted adolescents without FASD and community peers. Language, working memory, and affect regulation were particularly affected.
Pablo Carrera +3 more
wiley +1 more source
Multi‐ancestry genome‐wide association study of topiramate's effects on heavy alcohol use
Alcohol, Clinical and Experimental Research, EarlyView.Topiramate reduces alcohol consumption, but genetic predictors of treatment response have not been identified. We conducted a GWAS in 8386 individuals from the Million Veteran Program, evaluating genetic variants associated with the change in alcohol consumption before and after initiating topiramate.
Christal N. Davis +4 more
wiley +1 more source
Accelerated brain aging in alcohol users: Insights from machine learning
Alcohol, Clinical and Experimental Research, EarlyView.
Zhenhao Shi, Corinde E. Wiers
wiley +1 more source
Mechanisms of alcohol influence on fear conditioning: A computational model
Alcohol, Clinical and Experimental Research, EarlyView.Computational models can test mechanistic relationships between fear conditioning, neuroadaptations, and alcohol. Simulated fear extinction is slower and less robust under alcohol, as greater basolateral amygdala activation is needed. Alcohol shifts the amygdala network away from robust extinction by inhibiting central amygdala activity.
Adam Lonnberg +2 more
wiley +1 more source
Alcohol, Clinical and Experimental Research, EarlyView.We found that, after controlling for the level of daily alcohol use and demographic variables, those with a current anxiety or depression (“internalizing”) disorder (INTD) demonstrate significantly elevated relative odds of having all 37 alcohol‐related symptoms measured (a “harm paradox”).
Justin Anker +4 more
wiley +1 more source
Increased alcohol‐biased choice behavior in mouse models of high alcohol drinking
Alcohol, Clinical and Experimental Research, EarlyView.Mice that experienced chronic intermittent ethanol (CIE) exposure or CIE and forced swim stress (FSS) showed increased voluntary alcohol intake. In two separate studies, presentation of sucrose as an alternative reward reduced alcohol intake more readily in control mice compared with CIE and CIE + FSS groups.
Marcelo F. Lopez, Howard C. Becker
wiley +1 more source