Results 11 to 20 of about 66,025 (242)

ALDH3B1 Is an Independent Prognostic Biomarker of Lung Adenocarcinoma

Technology in Cancer Research & Treatment, 2020
Background: Lung cancer is the leading cause of cancer-related death, and adenocarcinoma is the most common type of lung cancer. Although emerging evidence implicates the role of several aldehyde dehydrogenases in cancer progression, the expression and ...
Hongmei Sun MD, Mingying Zhang MD, Li Li MD, Zongwen Huang MD   +3 more
doaj   +1 more source

Targeting aldehyde dehydrogenase for prostate cancer therapies

Frontiers in Oncology, 2022
Prostate cancer (PCa) is the most common cancer in men in the United States. About 10 – 20% of PCa progress to castration-resistant PCa (CRPC), which is accompanied by metastasis and therapeutic resistance.
Miao Ma, Wenyou He, Keyu Zhao, Linyuan Xue, Siyuan Xia, Baotong Zhang   +5 more
doaj   +1 more source

Development of a New Screen-Printed Transducer for the Electrochemical Detection of Thiram

Chemosensors, 2021
A new transducer based on a screen-printed carbon electrode has been developed for the quantification of thiram. Detection of this fungicide is based on the performance of two enzymes: (1) aldehyde dehydrogenase catalyzes the aldehyde oxidation using NAD+
David Ibáñez, Daniel Izquierdo-Bote, María Begoña González-García, David Hernández-Santos, Pablo Fanjul-Bolado   +4 more
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The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia

Haematologica, 2020
Leukemic stem cells are multipotent, self-renewing, highly proliferative cells that can withstand drug treatments. Although currently available treatments potentially destroy blast cells, they fail to eradicate leukemic progenitor cells completely ...
Charyguly Annageldiyev, Krishne Gowda, Trupti Patel, Priyanjali Bhattacharya, Su-Fern Tan, Soumya Iyer, Dhimant Desai, Sinisa Dovat, David J. Feith, Thomas P. Loughran, Shantu Amin, David Claxton, Arati Sharma   +12 more
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Insights into Aldehyde Dehydrogenase Enzymes: A Structural Perspective

Frontiers in Molecular Biosciences, 2021
Aldehyde dehydrogenases engage in many cellular functions, however their dysfunction resulting in accumulation of their substrates can be cytotoxic. ALDHs are responsible for the NAD(P)-dependent oxidation of aldehydes to carboxylic acids, participating ...
Kim Shortall, Ahmed Djeghader, Edmond Magner, Tewfik Soulimane   +3 more
doaj   +1 more source

SAXS fingerprints of aldehyde dehydrogenase oligomers

Data in Brief, 2015
Enzymes of the aldehyde dehydrogenase (ALDH) superfamily catalyze the nicotinamide adenine dinucleotide-dependent oxidation of aldehydes to carboxylic acids.
John J. Tanner
doaj   +1 more source

N-Substituted 2-(Benzenosulfonyl)-1-Carbotioamide Derivatives Exert Antimicrobial and Cytotoxic Effects via Aldehyde Dehydrogenase Pathway: Synthesis, In Silico and In Vitro Studies

Pharmaceuticals, 2023
A series of N-Substituted 2-(benzenosulfonyl)-1-carbotioamide derivatives (WZ1–WZ4) were synthesized and characterized using spectral methods. A comprehensive activity study was performed for each compound.
Lucja Walczak-Nowicka, Anna Biernasiuk, Wojciech Ziemichód, Zbigniew Karczmarzyk, Mateusz Kwaśnik, Paweł Kozyra, Waldemar Wysocki, Agnieszka Stenzel-Bembenek, Dorota Kowalczuk, Mariola Herbet, Monika Pitucha   +10 more
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Surviving environmental stress: the role of betaine aldehyde dehydrogenase in marine crustaceans [PDF]

Invertebrate Survival Journal, 2015
Betaine aldehyde dehydrogenase (BADH) belongs to the aldehyde dehydrogenases (ALDH) family, an ancestral group of enzymes responsible for aldehyde detoxification in several organisms.
NA Stephens-Camacho, A Muhlia-Almazan, A Sanchez-Paz, JA Rosas-Rodríguez   +3 more
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Aldehyde dehydrogenase 2-mediated aldehyde metabolism promotes tumor immune evasion by regulating the NOD/VISTA axis

Journal for ImmunoTherapy of Cancer, 2023
Background Aldehyde dehydrogenase 2 (ALDH2) is a crucial enzyme involved in endogenous aldehyde detoxification and has been implicated in tumor progression.
Qin Li, Jing Huang, Xiaoyi Wang, Huiying Fang, Guosheng Ren, Xiaoyu Wang, Yuru Chen, Jiazheng Sun, Jiazhou Liu, Yuxian Wei, Huimin Du, Hongzhong Li   +11 more
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Aldehyde dehydrogenase 2 and arrhythmogenesis

Heart Rhythm, 2022
Cardiac arrhythmia is a common cardiovascular disease that leads to considerable economic burdens and significant global public health challenges. Despite the remarkable progress made in recent decades, antiarrhythmic therapy remains suboptimal. Aldehyde dehydrogenase 2 (ALDH2), a critical detoxifying enzyme, catalyzes toxic aldehydes and protects ...
Junyan, Jin, Jieying, Chen, Yaping, Wang
openaire   +2 more sources