Results 21 to 30 of about 329,736 (281)

Annotation of 1350 Common Genetic Variants of the 19 ALDH Multigene Family from Global Human Genome Aggregation Database (gnomAD)

Biomolecules, 2021
Human aldehyde dehydrogenase (ALDH) is a multigene family with 19 functional members encoding a class of diverse but important enzymes for detoxification or biotransformation of different endogenous and exogenous aldehyde substrates. Genetic mutations in
Che-Hong Chen, Benjamin R. Kraemer, Lucia Lee, Daria Mochly-Rosen   +3 more
doaj   +1 more source

Surviving environmental stress: the role of betaine aldehyde dehydrogenase in marine crustaceans [PDF]

Invertebrate Survival Journal, 2015
Betaine aldehyde dehydrogenase (BADH) belongs to the aldehyde dehydrogenases (ALDH) family, an ancestral group of enzymes responsible for aldehyde detoxification in several organisms.
NA Stephens-Camacho, A Muhlia-Almazan, A Sanchez-Paz, JA Rosas-Rodríguez   +3 more
doaj   +2 more sources

Activity of the cytosolic enzymes of endogenous aldehydes catabolism under the conditions of different nutrients content in a diet

Біологія тварин, 2022
The research was conducted to study the activity of aldehyde dehydrogenase (EC 1.2.1.3) and aldehyde reductase (EC 1.1.1.21), the levels of TBA reactive substances and protein carbonyl derivates in the cytosolic fraction of rat liver under the conditions
O. M. Voloshchuk, T. V. Luchyk
doaj   +1 more source

A novel bifunctional aldehyde/alcohol dehydrogenase catalyzing reduction of acetyl-CoA to ethanol at temperatures up to 95 °C

Scientific Reports, 2021
Hyperthermophilic Thermotoga spp. are excellent candidates for the biosynthesis of cellulosic ethanol producing strains because they can grow optimally at 80 °C with ability to degrade and utilize cellulosic biomass. In T.
Qiang Wang, Chong Sha, Hongcheng Wang, Kesen Ma, Juergen Wiegle, Abd El-Fatah Abomohra, Weilan Shao   +6 more
doaj   +1 more source

Targeting aldehyde dehydrogenase for prostate cancer therapies

Frontiers in Oncology, 2022
Prostate cancer (PCa) is the most common cancer in men in the United States. About 10 – 20% of PCa progress to castration-resistant PCa (CRPC), which is accompanied by metastasis and therapeutic resistance.
Miao Ma, Wenyou He, Keyu Zhao, Linyuan Xue, Siyuan Xia, Baotong Zhang   +5 more
doaj   +1 more source

Evolution of aldehyde dehydrogenase genes and proteins in diploid and allotetraploid Xenopus frog species

, 2021
At least 19 human aldehyde dehydrogenase (ALDH) genes and enzymes have been studied among vertebrate organisms. BLAT and BLAST analyses were undertaken of Xenopus tropicalis (western clawed frog) and Xenopus laevis (African clawed frog) genomes which are
Holmes, Roger S, Roger S. Holmes
core   +1 more source

Determination of Aldehyde Dehydrogenase (ALDH) Isozymes in Human Cancer Samples - Comparison of Kinetic and Immunochemical Assays

Molecules, 2002
A fluorimetric assay of aldehyde dehydrogenase isozymes, based on naphthaldehyde oxidation, is compared with Western Blotting analysis on several clinical samples obtained from surgery.
Dorota Borecka, Magdalena Blazejczyk, Jakub Golab, Jacek Wierzchowski, Piotr Wroczynski   +4 more
doaj   +1 more source

Characterization of mouse liver cytosolic aldehyde dehydrogenase gene.

, 1990
Characterization of mouse liver cytosolic aldehyde dehydrogenase ...
Pornpimol. Rongnoparut (7959656)
core   +3 more sources

ALDH2 (aldehyde dehydrogenase 2 family (mitochondrial)) [PDF]

, 2002
Review on ALDH2 (aldehyde dehydrogenase 2 family (mitochondrial)), with data on DNA, on the protein encoded, and where the gene is ...
Sophos, N, Vasiliou, V
core   +1 more source

The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia

Haematologica, 2020
Leukemic stem cells are multipotent, self-renewing, highly proliferative cells that can withstand drug treatments. Although currently available treatments potentially destroy blast cells, they fail to eradicate leukemic progenitor cells completely ...
Charyguly Annageldiyev, Krishne Gowda, Trupti Patel, Priyanjali Bhattacharya, Su-Fern Tan, Soumya Iyer, Dhimant Desai, Sinisa Dovat, David J. Feith, Thomas P. Loughran, Shantu Amin, David Claxton, Arati Sharma   +12 more
doaj   +1 more source