Kinetic modelling of the role of the aldehyde dehydrogenase enzyme and the breast cancer resistance protein in drug resistance and transport [PDF]
, 2011 A compartmental model for the in vitro uptake kinetics of the anti-cancer agent topotecan (TPT) has been extended from a previously published model. The extended model describes the drug activity and delivery of the pharmacologically active form to the ...
N.D. Evans +13 more
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A Prodrug Strategy for the In Vivo Imaging of Aldehyde Dehydrogenase Activity [PDF]
, 2022 Therapy resistance is one of the biggest challenges facing clinical oncology. Despite a revolution in new anti-cancer drugs targeting multiple components of the tumour microenvironment, acquired or innate resistance frequently blunts the efficacy of ...
Raul , Pereira +5 more
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Functional characterization of SlscADH1, a fruit-ripening associated short-chain alcohol dehydrogenase of tomato [PDF]
, 2012 A tomato short-chain dehydrogenase-reductase (SlscADH1) is preferentially expressed in fruit with a maximum expression at the breaker stage while expression in roots, stems, leaves and flowers is very weak.
Moummou, Hanane +8 more
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SAXS fingerprints of aldehyde dehydrogenase oligomers
Data in Brief, 2015 Enzymes of the aldehyde dehydrogenase (ALDH) superfamily catalyze the nicotinamide adenine dinucleotide-dependent oxidation of aldehydes to carboxylic acids.
John J. Tanner
doaj +1 more source
Pharmaceuticals, 2023 A series of N-Substituted 2-(benzenosulfonyl)-1-carbotioamide derivatives (WZ1–WZ4) were synthesized and characterized using spectral methods. A comprehensive activity study was performed for each compound.
Lucja Walczak-Nowicka +10 more
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The Role of Pesticide-Induced Aldehyde Dehydrogenase Inhibition in the Pathogenesis of Parkinson’s Disease [PDF]
, 2012 Parkinson’s disease (PD) is a neurodegenerative disorder particularly characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. Its etiology is unknown but likely includes both genetic and environmental factors.
Fitzmaurice, Arthur Gerald, III
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Drosophila Melanogaster as a Model for Molybdo-Flavoenzyme Mediated Protection against Chemical and Physical Stress [PDF]
Aldehyde oxidase (AO) and xanthine oxidoreductase (XOR) are molybdo-flavoenzymes (MFEs) involved in the oxidation of hundreds of endogenous and exogenous aldehydes and N-heterocyclic compounds many of which are drugs, vitamins and environmental ...
Al Salhen, Khaled S
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Journal for ImmunoTherapy of Cancer, 2023 Background Aldehyde dehydrogenase 2 (ALDH2) is a crucial enzyme involved in endogenous aldehyde detoxification and has been implicated in tumor progression.
Qin Li +11 more
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Surviving environmental stress: the role of betaine aldehyde dehydrogenase in marine crustaceans [PDF]
Invertebrate Survival Journal, 2015 Betaine aldehyde dehydrogenase (BADH) belongs to the aldehyde dehydrogenases (ALDH) family, an ancestral group of enzymes responsible for aldehyde detoxification in several organisms.
NA Stephens-Camacho +3 more
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The Aldehyde Dehydrogenase Gene Superfamily Resource Center
Human Genomics, 2009 The website http://www.aldh.org is a publicly available database for nomenclature and functional and molecular sequence information for members of the aldehyde dehydrogenase (ALDH) gene superfamily for animals, plants, fungi and bacteria.
Black William, Vasiliou Vasilis
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