Results 21 to 30 of about 66,025 (242)

The Aldehyde Dehydrogenase Gene Superfamily Resource Center

Human Genomics, 2009
The website http://www.aldh.org is a publicly available database for nomenclature and functional and molecular sequence information for members of the aldehyde dehydrogenase (ALDH) gene superfamily for animals, plants, fungi and bacteria.
Black William, Vasiliou Vasilis
doaj   +1 more source

Unsupervised Learning for Feature Representation Using Spatial Distribution of Amino Acids in Aldehyde Dehydrogenase (ALDH2) Protein Sequences

Mathematics, 2022
Aldehyde dehydrogenase 2 (ALDH2) enzyme is required for alcohol detoxification. ALDH2 belongs to the aldehyde dehydrogenase family, the most important oxidative pathway of alcohol digestion. Two main liver isoforms of aldehyde dehydrogenase are cytosolic
Monika Khandelwal, Sabha Sheikh, Ranjeet Kumar Rout, Saiyed Umer, Saurav Mallik, Zhongming Zhao   +5 more
doaj   +1 more source

A Turkish family with Sjögren-Larsson syndrome caused by a novel ALDH3A2 mutation

Annals of Indian Academy of Neurology, 2013
Sjögren-Larsson syndrome (SLS) is an inherited neurocutaneous disorder caused by mutations in the aldehyde dehydrogenase family 3 member A2 (ALDH3A2) gene that encodes fatty aldehyde dehydrogenase. Affected patients display ichthyosis, mental retardation,
Faruk Incecik, Ozlem M Herguner, Wiliam B Rizzo, Sakir Altunbasak   +3 more
doaj   +1 more source

Association of acute myeloid leukemia’s most immature phenotype with risk groups and outcomes

Haematologica, 2016
The precise phenotype and biology of acute myeloid leukemia stem cells remain controversial, in part because the “gold standard” immunodeficient mouse engraftment assay fails in a significant fraction of patients and identifies multiple cell-types in ...
Jonathan M. Gerber, Joshua F. Zeidner, Sarah Morse, Amanda L. Blackford, Brandy Perkins, Breann Yanagisawa, Hao Zhang, Laura Morsberger, Judith Karp, Yi Ning, Christopher D. Gocke, Gary L. Rosner, B. Douglas Smith, Richard J. Jones   +13 more
doaj   +1 more source

The diagnostic value of alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) measurement in the sera of patients with brain tumor

Archives of Medical Science, 2017
Introduction: Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) exist in the brain. Alcohol dehydrogenase and ALDH are also present in brain tumor cells.
Wojciech Jelski, Magdalena Laniewska-Dunaj, Karolina Orywal, Jan Kochanowicz, Robert Rutkowski, Maciej Szmitkowski   +5 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Aldehyde Detoxification in Cancer: Metabolic Guardians of the Genome

Biomolecules
Reactive aldehydes are potent electrophiles that damage DNA and can ultimately promote cancer. While many aldehydes are ubiquitous in the environment, mammalian metabolism also generates high levels of endogenous aldehydes sufficient to threaten genome ...
Brandon T. James, Emma P. Kosmeder, Meng Wang   +2 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Metabolism of ethyl alcohol and the development of cancer

Alcoholism and Drug Addiction, 2018
The main metabolic pathway of ethanol elimination occurs in the liver. Ethanol is oxidised by an alcohol dehydrogenase (ADH) to a very toxic acetaldehyde. The aldehyde is converted to acetate by an aldehyde dehydrogenase (ALDH).
Wanda Dyr
doaj   +1 more source

Aldehyde dehydrogenase in tobacco pollen [PDF]

Plant Molecular Biology, 1997
Acetaldehyde is one of the intermediate products of ethanolic fermentation, which can be reduced to ethanol by alcohol dehydrogenase (ADH). Alternatively, acetaldehyde can be oxidized to acetate by aldehyde dehydrogenase (ALDH) and subsequently converted to acetyl-CoA by acetyl-CoA synthetase (ACS).
op den Camp RG, Kuhlemeier C
openaire   +3 more sources