Results 31 to 40 of about 262,052 (188)
Mathematics, 2022 Aldehyde dehydrogenase 2 (ALDH2) enzyme is required for alcohol detoxification. ALDH2 belongs to the aldehyde dehydrogenase family, the most important oxidative pathway of alcohol digestion. Two main liver isoforms of aldehyde dehydrogenase are cytosolic
Monika Khandelwal +5 more
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Structural features of stomach aldehyde dehydrogenase distinguish dimeric aldehyde dehydrogenase as a ‘variable’ enzyme ‘Variable’ and ‘constant’ enzymes within the alcohol and aldehyde dehydrogenase families [PDF]
, 1991 Stomach aldehyde dehydrogenase was structurally evaluated by analysis of peptide fragments of the human enzyme and comparisons with corresponding parts from other characterized aldehyde dehydrogenases. The results establish a large part of the structure,
Jörnvall, Hans +7 more
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Characterization of mouse mitochondrial aldehyde dehydrogenase.
, 1994 Characterization of mouse mitochondrial aldehyde ...
John Lawrence. Baloy (7951076)
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A Turkish family with Sjögren-Larsson syndrome caused by a novel ALDH3A2 mutation
Annals of Indian Academy of Neurology, 2013 Sjögren-Larsson syndrome (SLS) is an inherited neurocutaneous disorder caused by mutations in the aldehyde dehydrogenase family 3 member A2 (ALDH3A2) gene that encodes fatty aldehyde dehydrogenase. Affected patients display ichthyosis, mental retardation,
Faruk Incecik +3 more
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Betaine aldehyde dehydrogenase from rat liver mitochondrial matrix
, 2001 An NAD-linked aldehyde dehydrogenase which in addition to aliphatic and aromatic aldehydes, metabolizes aminoaldehydes and betaine aldehyde, has been purified to homogeneity from male Sprague–Dawley rat liver mitochondria.
Pietruszko, Regina +3 more
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, 2021 At least 19 human aldehyde dehydrogenase (ALDH) genes and enzymes have been studied among vertebrate organisms. BLAT and BLAST analyses were undertaken of Xenopus tropicalis (western clawed frog) and Xenopus laevis (African clawed frog) genomes which are
Holmes, Roger S
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Association of acute myeloid leukemia’s most immature phenotype with risk groups and outcomes
Haematologica, 2016 The precise phenotype and biology of acute myeloid leukemia stem cells remain controversial, in part because the “gold standard” immunodeficient mouse engraftment assay fails in a significant fraction of patients and identifies multiple cell-types in ...
Jonathan M. Gerber +13 more
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Aldehyde Detoxification in Cancer: Metabolic Guardians of the Genome
BiomoleculesReactive aldehydes are potent electrophiles that damage DNA and can ultimately promote cancer. While many aldehydes are ubiquitous in the environment, mammalian metabolism also generates high levels of endogenous aldehydes sufficient to threaten genome ...
Brandon T. James +2 more
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Metabolism of ethyl alcohol and the development of cancer
Alcoholism and Drug Addiction, 2018 The main metabolic pathway of ethanol elimination occurs in the liver. Ethanol is oxidised by an alcohol dehydrogenase (ADH) to a very toxic acetaldehyde. The aldehyde is converted to acetate by an aldehyde dehydrogenase (ALDH).
Wanda Dyr
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Gene Therapy Correction of Aldehyde Dehydrogenase 2 Deficiency
Molecular Therapy: Methods & Clinical Development, 2019 Aldehyde dehydrogenase 2 (ALDH2) deficiency causes “Asian flush syndrome,” presenting as alcohol-induced facial flushing, tachycardia, nausea, and headaches.
Yuki Matsumura +6 more
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