Results 111 to 120 of about 186,754 (233)

Improving hydrocarbon production by engineering cyanobacterial acyl-(acyl carrier protein) reductase

Biotechnology for Biofuels, 2019
Background Acyl-(acyl carrier protein (ACP)) reductase (AAR) is a key enzyme for hydrocarbon biosynthesis in cyanobacteria, reducing fatty acyl-ACPs to aldehydes, which are then converted into hydrocarbons by aldehyde-deformylating oxygenase (ADO ...
Hisashi Kudo, Yuuki Hayashi, Munehito Arai   +2 more
doaj   +1 more source

Structure of Aldehyde Reductase in Ternary Complex with a 5-Arylidene-2,4-thiazolidinedione Aldose Reductase Inhibitor

, 2010
The structure of aldehyde reductase (ALR1) in ternary complex with the coenzyme NADPH and [5-(3-carboxymethoxy-4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl]acetic acid (CMD), a potent inhibitor of aldose reductase (ALR2), was determined at 1.99 ...
A. Hara, O. El Kabbani, MACCARI, Rosanna, T. Huyton, V. Carbone, GIGLIO, MARCO, OTTANA', Rosaria, J. Adams, R. Chung   +8 more
core   +1 more source

Excessive training does not induce mitochondrial dysfunction or impair insulin signalling within skeletal muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Three weeks of overtraining in trained endurance athletes reduced exercise performance without impairing glucose tolerance. In skeletal muscle, overtraining was associated with increased expression of lipid metabolism‐related proteins, enhanced mitochondrial biogenesis and preserved insulin signalling, despite elevated oxidative ...
Geneviève J. DesOrmeaux, Henver S. Brunetta, Pierre‐Andre Barbeau, Alexandra M. Coates, Christopher Pignanelli, Fasih A. Rahman, Jamie F. Burr, Graham P. Holloway   +7 more
wiley   +1 more source

Biomarkers of oxidative stress, biochemical changes, and the activity of lysosomal enzymes in the livers of rainbow trout (Oncorhynchus mykiss Walbaum) vaccinated against yersiniosis before a Yersinia ruckeri challenge

Journal of Veterinary Research
This study aimed to evaluate biomarkers of oxidative stress (2-thiobarbituric acid reactive substances, aldehyde and ketone derivatives of oxidatively modified proteins and total antioxidant capacity), the activity of antioxidant enzymes (superoxide ...
Kurhaluk Natalia, Grudniewska Joanna, Pękala-Safińska Agnieszka, Pajdak-Czaus Joanna, Terech-Majewska Elżbieta, Platt-Samoraj Aleksandra, Tkaczenko Halina   +6 more
doaj   +1 more source

Investigation Into the Metabolism and Elimination Behavior of RU 58841, and Its Influence on the Steroid Profile in Humans

Biomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT RU 58841 is a nonsteroidal antiandrogen, developed for the treatment of androgen‐dependent conditions. This study aimed to characterize the human metabolism of RU 58841 for the first time and to assess its systemic exposure following topical administration.
Aylin Okutan, Oliver Krug, Gregor Fußhöller, Thomas Piper, Mario Thevis   +4 more
wiley   +1 more source

Multienzyme cascade for synthesis of hydroxytyrosol via engineered Escherichia coli

Scientific Reports
Hydroxytyrosol, a fine chemical, is widely utilized in food and pharmaceutical industries. In this study, we constructed a pathway to produce hydroxytyrosol by co-expressing tyrosin-phenol lyase (TPL), L-amino acid dehydrogenase (aadL), α-keto acid ...
Tianzhen Xiong, Xinmeng Li, Wei Liu, Huidie Yue, Junling Liu, Dingyuan Bai, Wei Li, Guangyan Fan   +7 more
doaj   +1 more source

An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B1 defines a subfamily of aldo-keto reductases

, 1993
Protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1) can be achieved through the induction of detoxification enzymes by chemoprotectors such as the phenolic antioxidant ethoxyquin.
Ellis, E. M., Hayes, J. D., Neal, G. E., Judah, D. J.   +3 more
core   +1 more source

Molecular genetical analysis of the nitrate gene cluster of Aspergillus nidulans [PDF]

, 2015
Putative DNA clones harbouring the nitrate gene cluster of Aspergillus nidulans was used in a number of transformation experiments to positively identify the clones.
Greaves, Philip Andrew
core   +2 more sources

Relaxin‐2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Xocas Vázquez‐Abuín, Lucía Gómez‐Cibeira, Javier García‐Seara, Pablo de la Fuente‐López, Carlos Minguito‐Carazo, Susana B. Bravo, Manuel Otero‐Santiago, Oreste Gualillo, José Ramón González‐Juanatey, Francisca Lago, Sandra Feijóo‐Bandín, Alana Aragón‐Herrera   +11 more
wiley   +1 more source

Aldehyde-Terminated Self-Assembled Monolayers on Gold:  Immobilization of Amines onto Gold Surfaces

, 2016
Aldehyde-Terminated Self-Assembled Monolayers on Gold:  Immobilization of Amines onto Gold ...
David C. Myles (2338201), Tonya M. Herne (3000147), Ronald C. Horton (3001506)   +2 more
core   +1 more source