Results 281 to 290 of about 194,755 (364)

Promiscuity‐Guided Enzyme Evolution via Substrate Multiplexed Screening

open access: yesAngewandte Chemie, EarlyView.
Through historical context and recent examples, this Minireview summarizes the strengths, limitations, and practical considerations for the implementation of substrate multiplexed screening (SUMS) in enzyme evolution. ABSTRACT An enzyme's ability to react with diverse substrates while maintaining high yield and selectivity, termed “substrate ...
Holly A. Weilbaker   +3 more
wiley   +1 more source

Programmable Solid‐Electrolyte Interfaces for Efficient and Selective Electrochemical Hydrogenations

open access: yesAngewandte Chemie, EarlyView.
Poly(ionic liquid) binders are shown to actively control the electrode microenvironment, strongly enhancing electrochemical hydrogenation compared to traditional binders. The work redefines the binder as an active component of catalytic electrode design, reshaping local potential gradients and interfacial ion distribution to modulate adsorbed H ...
Anastasios Orestis Grammenos   +9 more
wiley   +1 more source

Catalytic Enantioselective Multicomponent Reactions of Sulfoxonium Ylides Enabled by a Formal Rearrangement—A Versatile Entry to Enantioenriched α‐Sulfanyl Carbonyl Compounds

open access: yesAngewandte Chemie, EarlyView.
A catalytic network embedding a formal rearrangement enables the first catalytic enantioselective multicomponent reaction (MCR) of sulfur ylides. In the presence of a bulky chiral phosphoric acid, the reaction combines sulfoxonium ylides, aldehydes and thiols, and affords synthetically versatile β‐hydroxy‐α‐sulfanyl carbonyl compounds in ...
Nicolò Santarelli   +10 more
wiley   +1 more source

EnantioselectiveOrganophotocatalytic α‑Functionalizationof Aldehydes with N‑Lactam Radicals: A ViableStrategy for the Telescoped Synthesis of Levetiracetam

open access: green
Eleonora Colombo (5141723)   +6 more
openalex   +1 more source

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