Results 41 to 50 of about 23,764 (226)

ALDH Inhibition‐Primed Photocatalysis Disrupts Cancer Stemness Plasticity

Angewandte Chemie, EarlyView.
DE‐Et converts ALDH‐mediated redox buffering into a photoredox vulnerability by coupling ALDH inhibition with red‐light‐driven catalytic NADH oxidation. This enzyme‐coupled photoredox strategy sustains mitochondrial NADH/NAD+ imbalance, induces pyroptotic tumor cell death, suppresses tumor growth in vivo, and promotes systemic antitumor immunity ...
Yujin Kim, Shankun Yao, Ji Hyeon Kim, Rongrong Huang, Hyeonji Rha, Shumeng Li, Kippeum Lee, Yunjie Xu, Xiaogang Liu, Yuncong Chen, Jong Seung Kim   +10 more
wiley   +2 more sources

Foreskin-derived mesenchymal stromal cells with aldehyde dehydrogenase activity: isolation and gene profiling

BMC Cell Biology, 2018
Background Mesenchymal stromal cells (MSCs) become an attractive research topic because of their crucial roles in tissue repair and regenerative medicine.
Mehdi Najar, Emerence Crompot, Leo A. van Grunsven, Laurent Dollé, Laurence Lagneaux   +4 more
doaj   +1 more source

Functional Characteristics of Aldehyde Dehydrogenase and Its Involvement in Aromatic Volatile Biosynthesis in Postharvest Banana Ripening

Foods, 2022
Butanol vapor feeding to ripe banana pulp slices produced abundant butyl butanoate, indicating that a portion of butanol molecules was converted to butanoate/butanoyl-CoA via butanal, and further biosynthesized to ester. A similar phenomenon was observed
Yoshinori Ueda, Wei Zhao, Hideshi Ihara, Yoshihiro Imahori, Eleni Tsantili, Sumithra K. Wendakoon, Alan Chambers, Jinhe Bai   +7 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Functional Characterization of Aldehyde Dehydrogenase in Fusarium graminearum

Microorganisms, 2023
Aldehyde dehydrogenase (ALDH), a common oxidoreductase in organisms, is an aldehyde scavenger involved in various metabolic processes. However, its function in different pathogenic fungi remains unknown.
Lei Tang, Huanchen Zhai, Shuaibing Zhang, Yangyong Lv, Yanqing Li, Shan Wei, Pingan Ma, Shanshan Wei, Yuansen Hu, Jingping Cai   +9 more
doaj   +1 more source

Nanog Signaling Mediates Radioresistance in ALDH-Positive Breast Cancer Cells

International Journal of Molecular Sciences, 2019
Recently, cancer stem cells (CSCs) have been identified as the major cause of both chemotherapy and radiotherapy resistance. Evidence from experimental studies applying both in vitro and in vivo preclinical models suggests that CSCs survive after ...
Mozhgan Dehghan Harati, H. Rodemann, M. Toulany   +2 more
semanticscholar   +1 more source

Improved purification of hematopoietic stem cells based on their elevated aldehyde dehydrogenase activity

Haematologica, 2007
Background and Objectives Primitive human hematopoietic cells contain higher levels of aldehyde dehydrogenase (ALDH) activity than their terminally differentiating progeny but the particular stages at which ALDH levels change have not been well defined ...
Oliver Christ, Kai Lucke, Suzan Imren, Karen Leung, Melisa Hamilton, Allen Eaves, Clay Smith, Connie Eaves   +7 more
doaj   +1 more source

Underground Signals: The Ecological Power of Root Volatiles

Advanced Science, EarlyView.
Root volatiles mediate rhizosphere chemical communication, shaping interactions among plants, microbes, herbivores, and natural enemies. Their production, transport, and perception underpin ecological adaptation, multitrophic interactions, and plant resilience, offering opportunities for sustainable crop protection, resilient agroecosystems, and ...
Xueyao Cao, Nanli Song, François Verheggen, Meritxell Pérez‐Hedo, Andrea Clavijo McCormick, Antonino Cusumano, Arthur de Fouchier, Bing Wang, Chen‐Zhu Wang, Emmanuelle Jacquin‐Joly, Gary W. Felton, Geoff M. Gurr, Hao Guo, Jiancai Li, Jin Zhang, Li Chen, Manqun Wang, Michele Ricupero, Peng Han, Peng He, Qi Yan, Qingbo Tang, Qingsong Liu, Shiheng An, Xiangbo Kong, Xiaoling Sun, Xueming Ren, Yuanyuan Song, Yang Liu, Yanhui Guo, Yunhe Li, Xiao Sun   +31 more
wiley   +1 more source

Prognostic value of cancer stem cell marker aldehyde dehydrogenase in ovarian cancer: a meta-analysis.

PLoS ONE, 2013
ObjectiveAldehyde dehydrogenase (ALDH) has recently been reported as a marker of cancer stem-like cells in ovarian cancer. However, the prognostic role of ALDH in ovarian cancer still remains controversial.
Shuyan Liu, Chengfei Liu, Xiaoyun Min, Yuanyuan Ji, Na Wang, Dan Liu, Jiangyi Cai, Ke Li   +7 more
doaj   +1 more source

Poly(ADP-ribose) polymerase 1 (PARP1) overexpression in human breast cancer stem cells and resistance to olaparib. [PDF]

PLoS ONE, 2014
BACKGROUND:Breast cancer stem cells (BCSCs) have been recognized as playing a major role in various aspects of breast cancer biology. To identify specific biomarkers of BCSCs, we have performed comparative proteomics of BCSC-enriched and mature cancer ...
Marine Gilabert, Simon Launay, Christophe Ginestier, François Bertucci, Stéphane Audebert, Mathieu Pophillat, Yves Toiron, Emilie Baudelet, Pascal Finetti, Tetsuro Noguchi, Hagay Sobol, Daniel Birnbaum, Jean-Paul Borg, Emmanuelle Charafe-Jauffret, Anthony Gonçalves   +14 more
doaj   +1 more source