Galiellalactone inhibits stem cell-like ALDH-positive prostate cancer cells. [PDF]
PLoS ONE, 2011 Galiellalactone is a potent and specific inhibitor of STAT3 signaling which has been shown to possess growth inhibitory effects on prostate cancer cells expressing active STAT3.
Rebecka Hellsten +4 more
doaj +1 more source
Targeting aldehyde dehydrogenase for prostate cancer therapies
Frontiers in Oncology, 2022 Prostate cancer (PCa) is the most common cancer in men in the United States. About 10 – 20% of PCa progress to castration-resistant PCa (CRPC), which is accompanied by metastasis and therapeutic resistance.
Miao Ma +5 more
doaj +1 more source
Ovarian cancer stem cells are enriched in side population and aldehyde dehydrogenase bright overlapping population. [PDF]
PLoS ONE, 2013 Cancer stem-like cells (CSCs)/cancer-initiaiting cells (CICs) are defined as a small population of cancer cells that have self-renewal capacity, differentiation potential and high tumor-initiating ability.
Kazuyo Yasuda +11 more
doaj +1 more source
ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma. [PDF]
PLoS ONE, 2011 Multiple studies in recent years have identified highly tumorigenic populations of cells that drive tumor formation. These cancer stem cells (CSCs), or tumor-initiating cells (TICs), exhibit properties of normal stem cells and are associated with ...
Michael P Kim +8 more
doaj +1 more source
Genome-wide identification and analysis of grape aldehyde dehydrogenase (ALDH) gene superfamily. [PDF]
PLoS ONE, 2012 The completion of the grape genome sequencing project has paved the way for novel gene discovery and functional analysis. Aldehyde dehydrogenases (ALDHs) comprise a gene superfamily encoding NAD(P)(+)-dependent enzymes that catalyze the irreversible ...
Yucheng Zhang +7 more
doaj +1 more source
British Journal of Cancer, 2020 Background Ovarian cancer is characterised by frequent recurrence due to persistent presence of residual cancer stem cells (CSCs). Here, we identify and characterise tumour subsets from ascites-derived tumour cells with stemness, metastasis and metabolic
Yu-Xin Jiang +8 more
semanticscholar +1 more source
Aldehyde Dehydrogenase as a Marker of Early Mesenchymal Progenitor Cells in Donor Bone Marrow Stroma
Клиническая онкогематология, 2020 Aim. To analyze the growth rate of mesenchymal stromal cell (MSC) culture depending on the aldehyde dehydrogenase-positive (ALDH+) cell count. Materials & Methods.
Konstantin Aleksandrovich Vetoshkin +6 more
doaj +1 more source
Murine and human myogenic cells identified by elevated aldehyde dehydrogenase activity: implications for muscle regeneration and repair. [PDF]
PLoS ONE, 2011 Despite the initial promise of myoblast transfer therapy to restore dystrophin in Duchenne muscular dystrophy patients, clinical efficacy has been limited, primarily by poor cell survival post-transplantation.
Joseph B Vella +4 more
doaj +1 more source
Highly Stable, Cold-Active Aldehyde Dehydrogenase from the Marine Antarctic Flavobacterium sp. PL002
Fermentation, 2021 Stable aldehyde dehydrogenases (ALDH) from extremophilic microorganisms constitute efficient catalysts in biotechnologies. In search of active ALDHs at low temperatures and of these enzymes from cold-adapted microorganisms, we cloned and characterized a ...
Georgiana Necula-Petrareanu +5 more
doaj +1 more source
PLoS ONE, 2020 The bone marrow microenvironment (BME) in acute myeloid leukemia (AML) consists of various cell types that support the growth of AML cells and protect them from chemotherapy.
Bin Yuan +8 more
semanticscholar +1 more source