Results 11 to 20 of about 23,764 (226)

Evaluation of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24- subpopulations of breast cancer cells. [PDF]

PLoS ONE, 2013
STAT3 activation is frequently detected in breast cancer and this pathway has emerged as an attractive molecular target for cancer treatment. Recent experimental evidence suggests ALDH-positive (ALDH(+)), or cell surface molecule CD44-positive (CD44 ...
Li Lin, Brian Hutzen, Hsiu-Fang Lee, Zhengang Peng, Wenlong Wang, Chongqiang Zhao, Huey-Jen Lin, Duxin Sun, Pui-Kai Li, Chenglong Li, Hasan Korkaya, Max S Wicha, Jiayuh Lin   +12 more
doaj   +4 more sources

Update on the aldehyde dehydrogenase gene (ALDH) superfamily [PDF]

Human Genomics, 2011
Members of the aldehyde dehydrogenase gene (ALDH) superfamily play an important role in the enzymic detoxification of endogenous and exogenous aldehydes and in the formation of molecules that are important in cellular processes, like retinoic acid ...
Jackson Brian, Brocker Chad, Thompson David C, Black William, Vasiliou Konstandinos, Nebert Daniel W, Vasiliou Vasilis   +6 more
doaj   +3 more sources

Update of ALDH as a Potential Biomarker and Therapeutic Target for AML [PDF]

BioMed Research International, 2018
Studies employing mouse transplantation have illustrated the role of aldehyde dehydrogenase (ALDH) defining hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs).
Xiangchou Yang, Rongxin Yao, Hong Wang
semanticscholar   +3 more sources

Hydrostatic pressure activates HIF-1α via β-catenin to promote stemness in breast cancer cells. [PDF]

FEBS Open Bio
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Zhai D, Xu Y, Ma J, Duangrat R, Yan C, Liang J, Wei H, Jiang B, Li TS.   +8 more
europepmc   +2 more sources

Synthetic Shewanella-Bacillus Microbial Consortia for Enhanced Metal Oxide Leaching From Spent Lithium-Ion Batteries Using Brewing Wastewater as Leaching Agent. [PDF]

Adv Sci (Weinh)
A recycling approach of spent lithium‐ion batteries is developed using brewing wastewater as the leaching agent and an engineering microbial consortium as the biocatalyst. Shewanella oneidensis reduces spent LiNixCoyMn1‐x‐yO2 cathodes via extracellular electron transfer, while Bacillus subtilis removes residual ethanol to eliminate inhibition.
Zhang B, Qiao C, Liu H, Wang Y, Liu Y, Yu H, Zhang J, Li C, Wu D, Tang Q, Wang Z, Zhang D, Xu D, Li F, Song H.   +14 more
europepmc   +2 more sources

Blockade of ALDH in Cisplatin-Resistant Ovarian Cancer Stem Cells In Vitro Synergistically Enhances Chemotherapy-Induced Cell Death

Current Oncology, 2022
Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-related death. The high mortality and morbidity associated with EOC are mostly due to late diagnosis and chemotherapy drug resistance.
F. Guo, Zhi Yang, J. Sehouli, A. Kaufmann   +3 more
semanticscholar   +1 more source

IMMUNOHISTOCHEMICAL EXPRESSION OF STEM CELL MARKERS CD44, CD166 AND ALDH1A1 IN NON-NEOPLASTIC POLYPS OF THE COLON IN SAMPLE OF IRAQI PATIENTS [PDF]

Basrah Journal of Surgery, 2017
IMMUNOHISTOCHEMICAL EXPRESSION OF STEM CELL MARKERS CD44, CD166 AND ALDH1A1 IN NON-NEOPLASTIC POLYPS OF THE COLON IN SAMPLE OF IRAQI PATIENTS Nawal M Abdullah*, Mustafa M Ibraheem@ & Basim Sh Ahmed# *MB,ChB, MSc, Assist. Prof., Department of Anatomy,
Basim Sh Ahmed, Mustafa M Ibraheem, Nawal M Abdullah   +2 more
doaj   +1 more source

In Ovarian Cancer Multicellular Spheroids, Platelet Releasate Promotes Growth, Expansion of ALDH+ and CD133+ Cancer Stem Cells, and Protection against the Cytotoxic Effects of Cisplatin, Carboplatin and Paclitaxel

International Journal of Molecular Sciences, 2021
A high platelet count is associated with a poor prognosis in ovarian cancer (OvCa). Despite good clinical responses with platinating agents in combination with taxanes, numerous OvCa patients relapse due to chemotherapy resistance.
Naike Casagrande, C. Borghese, F. Agostini, C. Durante, M. Mazzucato, A. Colombatti, D. Aldinucci   +6 more
semanticscholar   +1 more source

The ALDH gene superfamily of Arabidopsis [PDF]

Trends in Plant Science, 2004
Aldehyde dehydrogenases (ALDHs) represent a protein superfamily of NAD(P)(+)-dependent enzymes that oxidize a wide range of endogenous and exogenous aliphatic and aromatic aldehydes. The Arabidopsis genome contains 14 unique ALDH sequences encoding members of nine ALDH families, including eight known families and one novel family (ALDH22) that is ...
Kirch, H., Bartels, D., Wei, Y., Schnable, P., Wood, A.   +4 more
openaire   +3 more sources

Aldehyde dehydrogenase (ALDH) activity does not select for cells with enhanced aggressive properties in malignant melanoma. [PDF]

PLoS ONE, 2010
BACKGROUND: Malignant melanoma is an exceptionally aggressive, drug-resistant and heterogeneous cancer. Recently it has been shown that melanoma cells with high clonogenic and tumourigenic abilities are common, but markers distinguishing such cells from ...
Lina Prasmickaite, Birgit Ø Engesaeter, Nirma Skrbo, Tina Hellenes, Alexandr Kristian, Nina K Oliver, Zhenhe Suo, Gunhild M Maelandsmo   +7 more
doaj   +1 more source