Results 1 to 10 of about 23,688 (160)

ALDEFLUOR activity, ALDH isoforms, and their clinical significance in cancers

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
High aldehyde dehydrogenase (ALDH) activity is a metabolic feature of adult stem cells and various cancer stem cells (CSCs). The ALDEFLUOR system is currently the most commonly used method for evaluating ALDH enzyme activity in viable cells.
Shi-Cang Yu, Jiao Cai, Jiang-Jie Duan
exaly   +4 more sources

Annotation of 1350 Common Genetic Variants of the 19 ALDH Multigene Family from Global Human Genome Aggregation Database (gnomAD)

Biomolecules, 2021
Human aldehyde dehydrogenase (ALDH) is a multigene family with 19 functional members encoding a class of diverse but important enzymes for detoxification or biotransformation of different endogenous and exogenous aldehyde substrates. Genetic mutations in
Daria Mochly-Rosen, Che-Hong Chen, Benjamin Kraemer   +2 more
exaly   +4 more sources

Inhibitory effect on ovarian cancer ALDH+ stem-like cells by Disulfiram and Copper treatment through ALDH and ROS modulation

Biomedicine and Pharmacotherapy, 2019
BACKGROUND Disulfiram (DSF) is a drug used for treatment of alcoholism that has also displayed promising anti-cancer activity. It unfolds its effects by inhibiting the enzyme activity of aldehyde dehydrogenase (ALDH) isoforms.
Andreas E Albers, Andreas Kaufmann
exaly   +2 more sources

Genome-Wide Identification and Functional Classification of Tomato (Solanum lycopersicum) Aldehyde Dehydrogenase (ALDH) Gene Superfamily. [PDF]

PLoS ONE, 2016
Aldehyde dehydrogenases (ALDHs) is a protein superfamily that catalyzes the oxidation of aldehyde molecules into their corresponding non-toxic carboxylic acids, and responding to different environmental stresses, offering promising genetic approaches for
Jose C Jimenez-Lopez, Francisco J Lopez-Valverde, Paula Robles-Bolivar, Elena Lima-Cabello, Emma W Gachomo, Simeon O Kotchoni   +5 more
doaj   +2 more sources

Identification of cancer-type specific expression patterns for active aldehyde dehydrogenase (ALDH) isoforms in ALDEFLUOR assay

Cell Biology and Toxicology, 2018
Aldehyde dehydrogenases (ALDHs) defend intracellular homeostasis by catalyzing the conversion of toxic aldehydes into non-toxic carboxylic acids, which is of particular importance to the self-renewal of stem cells and cancer stem cells.
Lei Zhou, Suling Liu, Sheng D
exaly   +2 more sources

Transcriptome analysis and prognosis of ALDH isoforms in human cancer

Scientific Reports, 2018
Overexpression of ALDH is associated with cancer stem-like features and poor cancer prognosis. High ALDH activity has been observed in cancer stem-like cells.
Peter Mu-Hsin Chang, Che-Hong Chen, Chi-Chun Yeh, Hsueh-Ju Lu, Tze-Tze Liu, Ming-Huang Chen, Chun-Yu Liu, Alexander T. H. Wu, Muh-Hwa Yang, Shyh-Kuan Tai, Daria Mochly-Rosen, Chi-Ying F. Huang   +11 more
doaj   +2 more sources

APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development.

PLoS ONE, 2020
APC mutations drive human colorectal cancer (CRC) development. A major contributing factor is colonic stem cell (SC) overpopulation. But, the mechanism has not been fully identified.
Tao Zhang, Koree Ahn, Brooks Emerick, Shirin R Modarai, Lynn M Opdenaker, Juan Palazzo, Gilberto Schleiniger, Jeremy Z Fields, Bruce M Boman   +8 more
doaj   +2 more sources

KK-LC-1 as a therapeutic target to eliminate ALDH+ stem cells in triple negative breast cancer

Nature Communications, 2023
The presence of breast cancer stem cells is associated with therapy resistance in patients with triple-negative breast cancer (TNBC). Here, the authors identify KK-LC-1-mediated YAP signaling as a driver of TNBC stemness and develop a therapeutic ...
Jia-Wen Bu, Yixiao Zhang, Sijin Wu, Hao-Nan Li, Lisha Sun, Yang Liu, Xudong Zhu, X. Qiao, Qingtian Ma, Chao Liu, Nan Niu, J. Xue, Guanglei Chen, Yongliang Yang, Cai-Gang Liu   +14 more
semanticscholar   +1 more source

Protective Effect and Mechanism of Aloe Bark Extract on Acute Alcoholic Liver Injury

Shipin gongye ke-ji, 2023
Objective: To explore the protective effect and mechanism of Aloe bark extract (ABE) on acute alcoholic liver injury. Methods: Firstly, the antioxidant activity of ABE was determined by DPPH, ABTS and hydroxyl radical scavenging tests in vitro ...
Jiahao CHU, Ruijun JU, Yuanhong FAN, Faliang WU, Xiaoming PENG, Simin YANG   +5 more
doaj   +1 more source

Keap1-Nrf2 Pathway Regulates ALDH and Contributes to Radioresistance in Breast Cancer Stem Cells

Cells, 2021
Tumor recurrence after radiotherapy due to the presence of breast cancer stem cells (BCSCs) is a clinical challenge, and the mechanism remains unclear.
D. Kamble, Megharani Mahajan, R. Dhat, S. Sitasawad   +3 more
semanticscholar   +1 more source