Results 31 to 40 of about 23,764 (226)

Increased Expression of Interleukin-1 Receptor Characterizes Anti-estrogen-Resistant ALDH+ Breast Cancer Stem Cells

Stem Cell Reports, 2020
Summary Estrogen-receptor-positive breast tumors are treated with anti-estrogen (AE) therapies but frequently develop resistance. Cancer stem cells (CSCs) with high aldehyde dehydrogenase activity (ALDH+ cells) are enriched following AE treatment.
Aida Sarmiento-Castro, E. Caamano-Gutierrez, A. Sims, Nathan J. Hull, M. James, A. Santiago-Gómez, R. Eyre, Christopher Clark, Martha E. Brown, Michael D. Brooks, M. Wicha, S. Howell, R. Clarke, B. Simões   +13 more
semanticscholar   +1 more source

High aldehyde dehydrogenase activity at diagnosis predicts relapse in patients with t(8;21) acute myeloid leukemia

Cancer Medicine, 2019
Acute myeloid leukemia (AML) with t(8;21) is a heterogeneous disease. Although the detection of minimal residual disease (MRD), which is indicated by RUNX1‐RUNX1T1 transcript levels, plays a key role in directing treatment, risk stratification needs to ...
Lu Yang, Wen‐Min Chen, Feng‐Ting Dao, Yan‐Huan Zhang, Ya‐Zhe Wang, Yan Chang, Yan‐Rong Liu, Qian Jiang, Xiao‐Hui Zhang, Kai‐Yan Liu, Xiao‐Jun Huang, Ya‐Zhen Qin   +11 more
doaj   +1 more source

Interaction of Aldehyde dehydrogenase with acetaminophen as examined by spectroscopies and molecular docking

Biochemistry and Biophysics Reports, 2017
The interaction of acetaminophen, a non-substrate anionic ligand, with Aldehyde Dehydrogenase was studied by fluorescence, UV–Vis absorption, and circular dichroism spectroscopies under simulated physiological conditions.
Ayodele O. Kolawole
doaj   +1 more source

ALDH-1-positive cells exhibited a radioresistant phenotype that was enhanced with hypoxia in cervical cancer

BMC Cancer, 2020
Background We have previously found there was a small subpopulation of cells with cancer stem cell-like phenotype ALDH-1 in cervical cancer. Radiotherapy has been applied in most of the cervical cancer.
Ting-Ting Yao, Xue-Ling Weng, Yao Yao, Chun-Xian Huang, Jing Li, Yong-Pai Peng, Rong-Chun Lin, Zhong-Qiu Lin   +7 more
semanticscholar   +1 more source

ALDH-Dependent Glycolytic Activation Mediates Stemness and Paclitaxel Resistance in Patient-Derived Spheroid Models of Uterine Endometrial Cancer

Stem Cell Reports, 2019
Summary Uterine endometrial cancer is associated with poor survival outcomes in patients with advanced-stage disease. Here, we developed a three-dimensional cell cultivation method of endometrioid cancer stem-like cells with high aldehyde dehydrogenase ...
Yutaro Mori, Kaoru Yamawaki, T. Ishiguro, K. Yoshihara, Haruka Ueda, A. Sato, H. Ohata, Y. Yoshida, T. Minamino, K. Okamoto, T. Enomoto   +10 more
semanticscholar   +1 more source

Transcriptomic analysis of Diffuse Intrinsic Pontine Glioma (DIPG) identifies a targetable ALDH-positive subset of highly tumorigenic cancer stem-like cells

Molecular Cancer Research, 2020
Understanding the cancer stem cell (CSC) landscape in diffuse intrinsic pontine glioma (DIPG) is desperately needed to address treatment resistance and identify novel therapeutic approaches.
R. Surowiec, Sarah F. Ferris, April A. Apfelbaum, Carlos E. Espinoza, Ranjit K. Mehta, Karamoja Monchamp, Veerin R. Sirihorachai, Karan Bedi, M. Ljungman, S. Galban   +9 more
semanticscholar   +1 more source

Selection of Tumorigenic Melanoma Cells Using ALDH [PDF]

Journal of Investigative Dermatology, 2010
Despite increasing knowledge regarding melanoma-initiating cells (MICs), questions persist regarding the number and phenotypic nature of cells with tumor-generating capability. Evidence for a phenotypically distinct human MIC has been found in NOD/SCID (non-obese diabetic/severe combined immunodeficiency) mice.
Boonyaratanakornkit, Jim B., Yue, Lili, Strachan, Lauren R., Scalapino, Kenneth J., LeBoit, Philip E., Lu, Ying, Leong, Stanley P., Smith, Janellen E., Ghadially, Ruby   +8 more
openaire   +2 more sources

Tegavivint and the β-catenin/ALDH Axis in Chemotherapy-Resistant and Metastatic Osteosarcoma.

Journal of the National Cancer Institute, 2019
BACKGROUND The Wnt/β-catenin pathway is closely associated with osteosarcoma (OS) development and metastatic progression. We investigated the antitumor activity of Tegavivint, a novel β-catenin/transducing β-like protein 1 (TBL1) inhibitor, against OS ...
Motonari Nomura, N. Rainusso, Yi-Chien Lee, B. Dawson, C. Coarfa, Ruolan Han, J. Larson, R. Shuck, L. Kurenbekova, J. Yustein   +9 more
semanticscholar   +1 more source

Human gut-associated Bifidobacterium species salvage exogenous indole, a uremic toxin precursor, to synthesize indole-3-lactic acid via tryptophan

Gut Microbes
Indole in the gut is formed from dietary tryptophan by a bacterial tryptophan-indole lyase. Indole not only triggers biofilm formation and antibiotic resistance in gut microbes but also contributes to the progression of kidney dysfunction after ...
Cheng Chung Yong, Takuma Sakurai, Hiroki Kaneko, Ayako Horigome, Eri Mitsuyama, Aruto Nakajima, Toshihiko Katoh, Mikiyasu Sakanaka, Takaaki Abe, Jin-Zhong Xiao, Miyuki Tanaka, Toshitaka Odamaki, Takane Katayama   +12 more
doaj   +1 more source

High NRF2 level mediates cancer stem cell-like properties of aldehyde dehydrogenase (ALDH)-high ovarian cancer cells: inhibitory role of all-trans retinoic acid in ALDH/NRF2 signaling

Cell Death and Disease, 2018
Aldehyde dehydrogenase 1A1 (ALDH1A1) is one of cancer stem cell (CSC) markers, and high ALDH1 expression has been related to drug resistance and facilitated tumor growth.
Donghyeok Kim, Bo-hyun Choi, In-geun Ryoo, M. Kwak   +3 more
semanticscholar   +1 more source