Results 71 to 80 of about 23,764 (226)

Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family

Human Genomics, 2005
The aldehyde dehydrogenase (ALDH) gene superfamily encodes enzymes that are critical for certain life processes and detoxification via the NAD(P)+-dependent oxidation of numerous endogenous and exogenous aldehyde substrates, including pharmaceuticals and
Vasiliou Vasilis, Nebert Daniel W
doaj   +1 more source

BET inhibitors suppress ALDH activity by targeting ALDH1A1 super-enhancer in ovarian cancer

Cancer Research, 2016
The emergence of tumor cells with certain stem-like characteristics such as high aldehyde dehydrogenase (ALDH) activity due to ALDH1A1 expression contributes to chemotherapy resistance and tumor relapse.
Yuhki Yokoyama, Heng-Rui Zhu, Jeong Heon Lee, A. Kossenkov, S. Wu, J. Wickramasinghe, Xiangfan Yin, Katherine C. Palozola, Alessandro Gardini, L. Showe, K. Zaret, Qin Liu, D. Speicher, J. Conejo-Garcia, J. Bradner, Zhi-Guo Zhang, A. Sood, Tamas Ordog, Benjamin G. Bitler, Rugang Zhang   +19 more
semanticscholar   +1 more source

Serotonin neuromicrobiology: Psychobiotic modulation of the gut–brain axis for mental health

Ibrain, EarlyView.
An overview of Psychobiotics and Tryptophan metabolism: A serotonin‐kynurenine crosstalk shaping the Gut‐Brain axis. IDO1, Indoleamine 2,3‐dioxygenase 1; 5‐HT3, 5‐hydroxytryptamine type 3; IFN‐γ, Interferon‐gamma; TNF‐α, Tumor necrosis factor‐alpha; IL‐1β, Interleukin‐1 beta; IL‐6, Interleukin 6; Trp, Tryptophan; 5‐HT, 5‐hydroxy‐tryptamine; 5‐HTP, 5 ...
Nidhi Mandloi, Aarzoo, Chakkaravarthi Saravanan, Heera Ram, Bhim Pratap Singh   +4 more
wiley   +1 more source

Identification of Novel Isatin Derivative Bearing a Nitrofuran Moiety as Potent Multi-Isoform Aldehyde Dehydrogenase Inhibitor

Molecules
Aldehyde dehydrogenases (ALDHs) are a family of enzymes that aid in detoxification and are overexpressed in several different malignancies. There is a correlation between increased expression of ALDH and a poor prognosis, stemness, and resistance to ...
Krishne Gowda, Asif Raza, Venugopal Vangala, Nazir Ahmad Lone, Jyh Ming Lin, Jaikee Kumar Singh, Sandeep Kumar Srivastava, Todd D. Schell, Gavin P. Robertson, Shantu Amin, Arun K. Sharma   +10 more
doaj   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Aldehyde Dehydrogenases: Not Just Markers, but Functional Regulators of Stem Cells

Stem Cells International, 2019
Aldehyde dehydrogenase (ALDH) is a superfamily of enzymes that detoxify a variety of endogenous and exogenous aldehydes and are required for the biosynthesis of retinoic acid (RA) and other molecular regulators of cellular function. Over the past decade,
Giuseppe Vassalli
doaj   +1 more source

ALDH1A3 Is the Key Isoform That Contributes to Aldehyde Dehydrogenase Activity and Affects in Vitro Proliferation in Cardiac Atrial Appendage Progenitor Cells

Frontiers in Cardiovascular Medicine, 2018
High aldehyde dehydrogenase (ALDHhi) activity has been reported in normal and cancer stem cells. We and others have shown previously that human ALDHhi cardiac atrial appendage cells are enriched with stem/progenitor cells. The role of ALDH in these cells
Stefania Puttini, Isabelle Plaisance, Lucio Barile, Elisabetta Cervio, Giuseppina Milano, Giuseppina Milano, Paola Marcato, Thierry Pedrazzini, Giuseppe Vassalli, Giuseppe Vassalli   +9 more
doaj   +1 more source

Correlation Between Prognostic Indicators, HPV Status, and Cancer Stem Cell Markers in a Population of Human Tongue Carcinomas

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Background Oral squamous cell carcinoma (OSCC) is a significant public health issue. While tobacco and alcohol are established risk factors, the role of human papillomavirus (HPV) in oral carcinogenesis remains debated. Cancer stem cells (CSCs) are implicated in tumor aggressiveness and therapy resistance.
Adriely Primo da Silva, Beatriz Gomes Carreira Sartori, Carolina de Barros Gigliotti Vendramini, Adauto José Ferreira Nunes, Maria Renata Sales Nogueira   +4 more
wiley   +1 more source

Adolescent lumbar disc herniation: etiology, diagnosis, and treatment options

Journal of Orthopaedic Surgery and Research
Adolescent lumbar disc herniation (ALDH) is a type of disease with a much lower incidence than adult lumbar disc herniation (LDH), which has a trend of increasing year by year.
Jing Zhang, Wanhao Zhang, Wenjie Yue, Wenhe Qin, Zhonghai Li, Gang Xu   +5 more
doaj   +1 more source

Glucosamine decreases the stemness of human ALDH+ breast cancer stem cells by inactivating STAT3.

Oncology Letters, 2018
Cancer stem cells (CSCs) are a subpopulation of cancer cells responsible for tumor maintenance and relapse due to their ability to resist various anticancer effects.
Rendy Hosea, N. Hardiany, O. Ohneda, S. I. Wanandi   +3 more
semanticscholar   +1 more source