Results 81 to 90 of about 23,764 (226)

Mapping the Bioenergetic Landscape of Oral Cancer Stem Cells: A Systematic Review

Oral Diseases, EarlyView.
ABSTRACT Objectives Oral squamous cell carcinoma (OSSC) remains highly lethal, with resistance largely driven by cancer stem cells (CSCs). Mitochondrial reprogramming supports CSC redox control, self‐renewal, and survival. This systematic review aimed to synthesize mitochondrial mechanisms sustaining CSCs in OSCC and evaluate their therapeutic ...
Rodrigo Elísio de Sá, Rebeca Barbosa da Rocha, Benedito dos Santos Alves, Maria Eduarda de Araujo de Carvalho, Jayane da Silva Sousa, José Delano Barreto Marinho‐Filho, Ana Jérsia Araújo   +6 more
wiley   +1 more source

Characterization of aldehyde dehydrogenase isozymes in ovarian cancer tissues and sphere cultures

BMC Cancer, 2012
Background Aldehyde dehydrogenases belong to a superfamily of detoxifying enzymes that protect cells from carcinogenic aldehydes. Of the superfamily, ALDH1A1 has gained most attention because current studies have shown that its expression is associated ...
Saw Yu-Ting, Yang Junzheng, Ng Shu-Kay, Liu Shubai, Singh Surendra, Singh Margit, Welch William R, Tsuda Hiroshi, Fong Wing-Ping, Thompson David, Vasiliou Vasilis, Berkowitz Ross S, Ng Shu-Wing   +12 more
doaj   +1 more source

Translating gut microbiome research into therapies for type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok, Max Nieuwdorp, Elena Rampanelli   +2 more
wiley   +1 more source

Expression of CD47, Aldehyde Dehydrogenase, and SOX4 Stem Cells in Different Colonic Lesions [PDF]

Al-Azhar International Medical Journal
Background: Colorectal cancer (CRC) patients have a higher likelihood of a favorable outcome when diagnosed early. Aime: This study aimed to evaluate the expression of CD47, Aldehyde Dehydrogenase (ALDH), SOX 4 stem cells in cancerous and precancerous ...
Olfat Hammam, Mohammed Badran, Mohamed Rozik, Mostafa EL Hawary, Mohamed El Sisi, Moataz Soliman   +5 more
doaj   +1 more source

Tobacco nitrosamine NNK increases ALDH-positive cells via ROS-Wnt signaling pathway in A549 human lung cancer cells.

Journal of Toxicological Sciences, 2017
Epidemiological studies suggest that lung cancer, which is a major cause of cancer death, has a critical association with cigarette smoking. Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in cigarette smoke is a major ...
Naoya Hirata, Shigeru Yamada, Y. Sekino, Y. Kanda   +3 more
semanticscholar   +1 more source

Disulfiram Attenuates Adenine‐Induced Renal Fibrosis by Modulating Inflammatory and Immunometabolic Responses

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Chronic kidney disease (CKD) is characterized by persistent inflammation that drives progressive renal injury and fibrosis. In this study, we demonstrate that disulfiram markedly attenuates kidney injury and fibrosis in adenine‐induced nephropathy by suppressing innate immune responses and reducing DNA damage and cellular senescence.
Saori Kin, Yuji Oe, Shun Ishigaki, Ichiro Fujio, Mariko Miyazaki, Tetsuhiro Tanaka   +5 more
wiley   +1 more source

Expression of Acetaldehyde Dehydrogenase in Gefitinib-resistant Human Lung Adenocarcinoma HCC-827/GR Cells

Chinese Journal of Lung Cancer, 2018
Background and objective Tumor recurrence and drug resistance are the main causes of death in tumor patients. The family of acetaldehyde dehydrogenase (ALDH) is closely related to the proliferation, migration, invasion and resistance of tumor cells, and ...
Tingting YANG, Jingjing GU, Ting LIU, Haibin MA, Xiaona MA, Jin TAO, Yiran JIN, Xueyun LIANG   +7 more
doaj   +1 more source

Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells

OncoTarget, 2016
The existence of cancer stem cells (CSCs) in non-small cell lung cancer (NSCLC) has profound implications for cancer therapy. In this study, a disulfiram/copper (DSF/Cu) complex was evaluated in vitro and in vivo for its efficacy to inhibit CSCs, which ...
Xinwei Liu, Li-Hui Wang, W. Cui, Xiangzhong Yuan, Lulu Lin, Q. Cao, Nannan Wang, Yi Li, Wei Guo, Xun Zhang, Chun-Fu Wu, Jing-Yu Yang   +11 more
semanticscholar   +1 more source

[Human aldehyde dehydrogenase (ALDH)].

Postepy higieny i medycyny doswiadczalnej, 2001
The paper presents the molecular and kinetics aspects of aldehyde dehydrogenase polymorphism. The role in acetaldehyde metabolism and differences in substrate specificity of isoenzymes are discussed.
W, Jelski, L, Chrostek, M, Szmitkowski
openaire   +1 more source

Relaxin‐2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Xocas Vázquez‐Abuín, Lucía Gómez‐Cibeira, Javier García‐Seara, Pablo de la Fuente‐López, Carlos Minguito‐Carazo, Susana B. Bravo, Manuel Otero‐Santiago, Oreste Gualillo, José Ramón González‐Juanatey, Francisca Lago, Sandra Feijóo‐Bandín, Alana Aragón‐Herrera   +11 more
wiley   +1 more source