Results 71 to 80 of about 2,516,365 (158)
Frontiers in Genetics, 2018 Non-alcoholic fatty liver disease (NAFLD) represents a wide spectrum of disease, ranging from simple fatty liver through steatosis with inflammation and necrosis to cirrhosis.
Alejandro Aguayo-Orozco +4 more
doaj +1 more source
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.Abstract INTRODUCTION Cognitive reserve (CR) reflects variability in cognitive adaptability that modifies the impact of Alzheimer's disease (AD) pathology on cognition. However, blood‐based biomarkers of CR have not been established in prodromal AD.
David Lukacsovich +11 more
wiley +1 more source
Epilepsia dependiente de piridoxina en paciente homocigoto para ALDH7A1 C.1093+1G>A
, 2023 Introduction: Neonatal seizures represent a neurological emergency and can be the initial manifestation of a rare and severe neurological disorder such as pyridoxine-dependent epilepsy, caused by a compound pathogenic variant in the ALDH7A1 gene, located
Palma-Montero, María Alejandra +3 more
core +1 more source
Advanced Science, Volume 13, Issue 8, 9 February 2026.Chemotherapy‐induced efferocytosis drives ovarian cancer stem cell enrichment. By engulfing apoptotic cancer cells, macrophages upregulate ODC1 and produce putrescine, which elevates osteopontin (OPN) expression. Secreted OPN then activates the CD44 receptor on cancer cells, promoting stemness and chemoresistance.
Wenhan Li +19 more
wiley +1 more source
Genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy (ALDH7A1 deficiency) [PDF]
, 2017 Pyridoxine-dependent epilepsy was recently shown to be due to mutations in the ALDH7A1 gene, which encodes antiquitin, an enzyme that catalyses the nicotinamide adenine dinucleotide-dependent dehydrogenation of l-α-aminoadipic semialdehyde/l-Δ1 ...
Tuschl, Karin +22 more
core
The Genetic and Morphological Basis of Local Adaptation to Elevational Extremes in an Alpine Finch
Ecology and Evolution, Volume 16, Issue 2, February 2026.We investigated morphological and genetic variation in the Sierra Nevada Gray‐crowned Rosy Finch to identify traits important for local adaptation in alpine environments. By combining trait measurements with genome‐wide analyses, we uncovered loci linked to thermoregulation, altitude adaptation, and cold tolerance.
Erica C. N. Robertson +6 more
wiley +1 more source
The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective
Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu +8 more
wiley +1 more source
Treatment of pediatric epilepsy
Pediatric Investigation, Volume 10, Issue 1, Page 86-100, February 2026.Anti‐seizure medications are the first‐line treatment for the vast majority of children with epilepsy, with the advantages of non‐invasive wide adaptability. Surgery is the main treatment for drug‐resistant epilepsy and lesion‐related epilepsy, which can cure some cases of epilepsy in children. A ketogenic diet is often an add‐on therapy.
Junxiao Li +8 more
wiley +1 more source
Expression pattern of aldh7a1 in zebrafish.
, 2014 Whole-mount in situ hybridization of aldh7a1 at (A) 24 hpf and (B) 48 hpf. L, lens; OF, optic fissure; PF, pectoral fin. Scale bar: 65 µm in A; 60 µm in B.
Chad Brocker (184166) +7 more
core +1 more source
mtDNA amount is not significantly reduced in aldh7a1 knock-out zebrafish.
, 2021 qPCR graph of mtDNA amount from wildtype (Wildtype, black circles) and aldh7a1 homozygous knock-out (aldh7a1 knock-out, grey squares) zebrafish embryos, demonstrating only a slight reduction in mtDNA copy number in knock-out relative to the wildtype ...
Anastasia Minenkova (11408438) +7 more
core +1 more source