Results 51 to 60 of about 84,187 (148)

The Effects of Aldosterone on Hypertension-Associated Kidney Injury in a Tg-hAS Mouse Model

Biology
Hypertension remains a global health challenge due to its high prevalence and association with premature morbidity and mortality. Aldosterone, a mineralocorticoid hormone, and its receptor, the mineralocorticoid receptor (MR), are highly implicated in ...
Huiying Gu, Zhe Chen, Nicole Du, Sisi Yang, Yongqi Yu, Yansheng Du   +5 more
doaj   +1 more source

Hypokalemia and Pendrin Induction by Aldosterone

HYPERTENSION, 2017
Aldosterone plays an important role in regulating Na-Cl reabsorption and blood pressure. Epithelial Na+ channel, Na+-Cl− cotransporter, and Cl−/HCO3− exchanger pendrin are the major mediators of Na-Cl transport in the aldosterone-sensitive distal nephron.
Ning Xu, D. Hirohama, Kenichi Ishizawa, W. Chang, T. Shimosawa, T. Fujita, S. Uchida, S. Shibata   +7 more
semanticscholar   +1 more source

Role of the Renin-Angiotensin System and Aldosterone on Cardiometabolic Syndrome

International Journal of Hypertension, 2011
Aldosterone facilitates cardiovascular damage by increasing blood pressure and through different mechanisms that are independent of its effects on blood pressure.
P. Stiefel, A. J. Vallejo-Vaz, S. García Morillo, J. Villar   +3 more
doaj   +1 more source

Aldosterone induces inflammatory cytokines in penile corpus cavernosum by activating the NF-κB pathway

Asian Journal of Andrology, 2018
Emerging evidence indicates that aldosterone and mineralocorticoid receptors (MRs) are associated with the pathogenesis of erectile dysfunction. However, the molecular mechanisms remain largely unknown.
Fei Wu, Zu-Quan Xiong, Shan-Hua Mao, Ji-Meng Hu, Jian-Qing Wang, Hao-Wen Jiang, Qiang Ding   +6 more
doaj   +1 more source

Dynamic changes of renin-angiotensin-aldosterone system parameters after surgery of primary hyperparathyroidism

Терапевтический архив, 2020
Aim.To study an activity of the Renin-Angiotensin-Aldosterone System (RAAS) components in patients with primary hyperparathyroidism (PHPT) before and after parathyroidectomy (PTE).
E. A. Dobreva, E. E. Bibik, A. K. Eremkina, A. R. Ajnetdinova, L. V. Nikankina, N. M. Malysheva, N. G. Mokrysheva   +6 more
doaj   +1 more source

Diagnostic and prognostic value of pituitary-adrenal system hormones in cerebrospinal fluid of patients with acute neuroinfection

Zaporožskij Medicinskij Žurnal, 2018
The purpose of the work. To determine the diagnostic and predictive significance of the pituitary-adrenal system hormones levels in the cerebrospinal fluid of patients with acute neuroinfections due to different etiology. Materials and methods.
A. V. Sokhan
doaj   +1 more source

Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism

Nature Genetics, 2013
Adrenal aldosterone-producing adenomas (APAs) constitutively produce the salt-retaining hormone aldosterone and are a common cause of severe hypertension. Recurrent mutations in the potassium channel gene KCNJ5 that result in cell depolarization and Ca2+
U. Scholl, Gerald Goh, Gabriel Stölting, R. C. de Oliveira, Murim Choi, J. Overton, Annabelle L. Fonseca, R. Korah, Lee F. Starker, J. Kunstman, M. Prasad, Erum A. Hartung, N. Mauras, M. Benson, T. Brady, J. Shapiro, E. Loring, C. Nelson-Williams, S. Libutti, S. Mane, P. Hellman, G. Westin, G. Åkerström, P. Björklund, T. Carling, C. Fahlke, P. Hidalgo, R. Lifton   +27 more
semanticscholar   +1 more source

Rapid Action of Aldosterone on Protein Levels of Sodium-Hydrogen Exchangers and Protein Kinase C Beta Isoforms in Rat Kidney

International Journal of Endocrinology, 2017
Previous in vitro studies demonstrated that aldosterone rapidly activates sodium-hydrogen exchangers 1 and 3 (NHE 1 and 3). In vitro investigations revealed that protein kinase C (PKC) regulates NHE properties. We previously demonstrated that aldosterone
Somchit Eiam-Ong, Mookda Chaipipat, Krissanapong Manotham, Somchai Eiam-Ong   +3 more
doaj   +1 more source

A SELECTIVE ANTAGONIST OF MINERALOCORTICOID RECEPTOR EPLERENONE IN CARDIOLOGY PRACTICE

Рациональная фармакотерапия в кардиологии, 2015
The role of aldosterone in pathophysiological processes is considered. The effects of the selective antagonist of mineralocorticoid receptor eplerenone are analyzed. The advantages of eplerenone compared with spironolactone are discussed.
B. B. Gegenava, O. M. Drapkina
doaj   +1 more source

INVERSION OF THE CONCEPT ABOUT BIOLOGICAL ROLE OF RENIN → ANGIOTENSIN-II → ALDOSTERONE SYSTEM AND FUNCTION OF ARTERIAL BLOOD PRESSURE AS A METABOLISM REGULATOR

Евразийский Кардиологический Журнал, 2015
The phylogenetic theory of general pathology postulates an inversion of the concept about the role of arterial blood pressure (AP) in physiology and pathology. Activation of the synthesis of the renin → angiotensin-II (AG-II) system components by nephron
V. N. Titov
doaj   +1 more source