Results 51 to 60 of about 231,871 (392)
International Journal of Molecular Sciences, 2016 Arterial hypertension is a common condition worldwide and an important predictor of several complicated diseases. Arterial hypertension can be triggered by many factors, including physiological, genetic, and lifestyle causes.
N. Muñoz-Durango +6 more
semanticscholar +1 more source
Hypertension Renin–Angiotensin–Aldosterone System Alterations
, 2015 Blockers of the renin-angiotensin-aldosterone system (RAAS), that is, renin inhibitors, angiotensin (Ang)-converting enzyme (ACE) inhibitors, Ang II type 1 receptor antagonists, and mineralocorticoid receptor antagonists, are a cornerstone in the ...
L. Riet +4 more
semanticscholar +1 more source
PLoS ONE, 2014 Prolonged elevations of plasma aldosterone levels are associated with renal pathogenesis. We hypothesized that renal distress could be imposed by an augmented aldosterone-induced protein turnover challenging cellular protein degradation systems of the ...
Muhammad Umar Cheema +6 more
doaj +1 more source
The Biology of Normal Zona Glomerulosa and Aldosterone-Producing Adenoma: Pathological Implications
Endocrine reviews, 2018 The identification of several germline and somatic ion channel mutations in aldosterone-producing adenomas (APAs) and detection of cell clusters that can be responsible for excess aldosterone production, as well as the isolation of autoantibodies ...
T. Seccia +4 more
semanticscholar +1 more source
Real-World Effectiveness of Mineralocorticoid Receptor Antagonists in Primary Aldosteronism
Frontiers in Endocrinology, 2021 ObjectiveTo investigate how often target renin is pursued and achieved in patients with primary aldosteronism (PA) and other low renin hypertension (LRH) treated with mineralocorticoid receptor antagonists (MRAs), as reversal of renin suppression was ...
Yuta Tezuka, Yuta Tezuka, Adina F. Turcu
doaj +1 more source
Aldosterone and Mineralocorticoid Receptors—Physiology and Pathophysiology
International Journal of Molecular Sciences, 2017 Aldosterone is a uniquely terrestrial hormone, first appearing in lungfish, which have both gills and lungs. Mineralocorticoid receptors (MRs), on the other hand, evolved much earlier, and are found in cartilaginous and bony fish, presumptive ligand ...
J. Funder
semanticscholar +1 more source
THE GENDER FEATURES OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN HYPERTENSIVE PATIENTS
Рациональная фармакотерапия в кардиологии, 2016 Aim. To study the correlation of the renin-angiotensin-aldosterone system (RAAS) activity with the female sex hormone levels and markers of target organ damage in patients with arterial hypertension (HT).Material and methods. Patients with HT (20 men and
V. I. Podzolkov +3 more
doaj +1 more source
Primary Aldosteronism, Aldosterone, and Extracellular Vesicles
Endocrinology, 2021 Abstract Primary aldosteronism (PA) is an endocrine related condition leading to arterial hypertension due to inappropriately high and unregulated aldosterone concentration. Recently, a broad spectrum of PA has been recognized, which brings new challenges associated with early identification of this condition that affect renal epithelial
Cristian A Carvajal +3 more
openaire +2 more sources
Activating mutations in CTNNB1 in aldosterone producing adenomas
Scientific Reports, 2016 Primary aldosteronism (PA) is the most common cause of secondary hypertension with a prevalence of 5–10% in unreferred hypertensive patients. Aldosterone producing adenomas (APAs) constitute a large proportion of PA cases and represent a surgically ...
T. Åkerström +15 more
semanticscholar +1 more source
Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications [PDF]
, 2016 Aging is the primary risk factor underlying hypertension and incident cardiovascular disease. With aging, the vasculature undergoes structural and functional changes characterized by endothelial dysfunction, wall thickening, reduced distensibility, and ...
Harvey, Adam +4 more
core +1 more source