Impact of generic alendronate cost on the cost-effectiveness of osteoporosis screening and treatment. [PDF]
PLoS ONE, 2012 Since alendronate became available in generic form in the Unites States in 2008, its price has been decreasing. The objective of this study was to investigate the impact of alendronate cost on the cost-effectiveness of osteoporosis screening and ...
Smita Nayak +2 more
doaj +12 more sources
Effectiveness of treatments to prevent femoral periprosthetic bone loss following total hip arthroplasty: a network meta-analysis [PDF]
Frontiers in PharmacologyBackgroundThe objective of this study was to conduct a systematic review and network meta-analysis (NMA) to compare the efficacy of various anti-osteoporosis drugs in preventing femoral periprosthetic bone loss following total hip arthroplasty (THA ...
Zhi-Hu Zhao +5 more
doaj +2 more sources
Comparative Molecular Docking, Molecular Dynamics and Adsorption–Release Analysis of Calcium Fructoborate and Alendronate Salts on Hydroxyapatite and Hydroxyapatite–Titanium Implants [PDF]
BiomedicinesBackground/Objectives: Hydroxyapatite (HAp)-based implants and HAp–titanium (HApTi) composites are widely used in orthopedic and dental applications, but their long-term success is limited by peri-implant bone loss.
Diana-Maria Trasca +6 more
doaj +2 more sources
Duration and timing of bisphosphonate treatment as factors determining osteoblast mineralization
Journal of Oral Biology and Craniofacial Research, 2022 Background: Alendronate is a drug for the treatment of excessive bone resorption. Alendronate reduces osteoblast viability and mineralization in a dose-dependent manner. Other views of alendronate could affect mineralization.
Somying Patntirapong
doaj +1 more source
Alendronate reduced peri-tunnel bone loss and enhanced tendon graft to bone tunnel healing in anterior cruciate ligament reconstruction [PDF]
European Cells & Materials, 2013 Peri-tunnel bone loss after anterior cruciate ligament (ACL) reconstruction is commonly observed, both clinically and experimentally. We aimed to study the effect and mechanisms of different doses of alendronate in the reduction of peri-tunnel bone loss ...
PPY Lui +4 more
doaj +2 more sources
Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis [PDF]
, 2006 BACKGROUND: Treatment with glucocorticoids is associated with bone loss starting soon after therapy is initiated and an increased risk of fracture. METHODS: We performed a randomized, double-placebo, double-blind clinical trial of 18 months' duration ...
Ale Algra +14 more
core +10 more sources
Acta Crystallographica Section E Structure Reports Online, 2012 The title compound {systematic name: bis(μ2-dihydrogen 4-azaniumyl-1-hydroxybutane-1,1-diphosphonato)bis[aqua(dihydrogen 4-azaniumyl-1-hydroxybutane-1,1-diphosphonato)nickel(II)] dihydrate}, [Ni2(C4H12NO7P2)4(H2O)2]·2H2O, was synthesiized under hydrothermal conditions. Its structure is isotypic with the CoII analogue.
Małgorzata Sikorska +2 more
openaire +3 more sources
Impairment of cold injury-induced muscle regeneration in mice receiving a combination of bone fracture and alendronate treatment. [PDF]
PLoS ONE, 2017 Alendronate, a nitrogen-containing bisphosphonate, is well established as a treatment for osteoporosis through regulation of osteoclast activity. Previously, the pharmacological effects of bisphosphonates on cells outside the bone environment have been ...
Shigeo Kawada +2 more
doaj +1 more source
BMC Women's Health, 2022 Background Postmenopausal women compliance to alendronate therapy is suboptimal due to the complex dosing requirements. The poor compliance may increase their potential of fractures and the prevalence of side effects.
Asma Radwan +7 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Alendronate is the most widely used drug for postmenopausal osteoporosis (PMO). It inhibits bone resorption, affecting osteoclasts. Pharmacokinetics (PK) and pharmacodynamics (PD) of alendronate have been widely studied, but few mathematical models exist
José L. Calvo-Gallego +3 more
doaj +1 more source