The Extracellular Matrix Component Psl Provides Fast-Acting Antibiotic Defense in Pseudomonas aeruginosa Biofilms [PDF]
, 2012 Bacteria within biofilms secrete and surround themselves with an extracellular matrix, which serves as a first line of defense against antibiotic attack.
AA Hammond +82 more
core +3 more sources
Intratumoral bacteria engineered for tumor therapy
Interdisciplinary Medicine, Volume 4, Issue 2, March 2026.This article comprehensively reviews engineered intratumoral bacteria used in tumor therapy. The concept development, characteristics, and engineering methods of intratumoral bacteria are summarized. The mechanisms and the translational significance by which engineered intratumoral bacteria interfere with tumor progression are discussed and highlighted.
Huajie Zhang +7 more
wiley +1 more source
Marine Bacteria, A Source for Alginolytic Enzyme to Disrupt Pseudomonas aeruginosa Biofilms
Marine Drugs, 2019 Pseudomonas aeruginosa biofilms are typically associated with the chronic lung infection of cystic fibrosis (CF) patients and represent a major challenge for treatment. This opportunistic bacterial pathogen secretes alginate, a polysaccharide that is one
Said M. Daboor +4 more
doaj +1 more source
Regulation of pH attenuates toxicity of a byproduct produced by an ethanologenic strain of Sphingomonas sp. A1 during ethanol fermentation from alginate [PDF]
, 2014 Marine macroalgae is a promising carbon source that contains alginate and mannitol as major carbohydrates. A bioengineered ethanologenic strain of the bacterium Sphingomonas sp.
Fujii, Mari +3 more
core +1 more source
Characterization of a Novel Alginate Lyase from Marine Bacterium Vibrio furnissii H1
Marine Drugs, 2018 Alginate lyases show great potential for industrial and medicinal applications, especially as an attractive biocatalyst for the production of oligosaccharides with special bioactivities.
Xiaoyan Zhu +7 more
doaj +1 more source
Dynamic energy budget approach to evaluate antibiotic effects on biofilms [PDF]
, 2017 Quantifying the action of antibiotics on biofilms is essential to devise therapies against chronic infections. Biofilms are bacterial communities attached to moist surfaces, sheltered from external aggressions by a polymeric matrix.
Birnir, Bjorn +3 more
core +3 more sources
Applications of Alginate-Based Bioinks in 3D Bioprinting. [PDF]
, 2016 Three-dimensional (3D) bioprinting is on the cusp of permitting the direct fabrication of artificial living tissue. Multicellular building blocks (bioinks) are dispensed layer by layer and scaled for the target construct.
Axpe, Eneko, Oyen, Michelle L
core +2 more sources
An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation. [PDF]
, 2019 Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for multiple disorders, but deficiency and dysregulation of T cells limit its utility.
Deruaz, Maud +11 more
core +1 more source
Hyaluronan-cholesterol nanohydrogels: Characterisation and effectiveness in carrying alginate lyase
New Biotechnology, 2017 Although in recent years several methods have been studied and developed to obtain different types of nanosized drug delivery systems, the set up of suitable procedures and materials remains highly expensive, their preparation is time consuming and often not feasible for a scale-up process.
MONTANARI, ELITA +9 more
openaire +6 more sources
A novel bleb-dependent polysaccharide export system in nitrogen-fixing Azotobacter vinelandii subjected to low nitrogen gas levels [PDF]
, 2013 The alginate biofilm-producing bacterium Azotobacter vinelandii aerobically fixes nitrogen by oxygensensitivenitrogenases. Here we investigated the bacterial response to nitrogen/oxygen gas mixtures. A.
Fuminori Yoneyama +4 more
core +1 more source