Results 111 to 120 of about 84,539 (289)

Pared-down landscapes in Antarctica [PDF]

open access: yes, 1971
The frigid-arid climate that now prevails in ice-free parts of Victoria Land, Antarctica, inhibits glacial erosion. If certain landscapes, more or less remote from the great troughs of outlet glaciers, have been glaciated in the past, as seems very ...
Cotton, C.A., Wilson, A.T.
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

CONSIDERATIONS ABOUT PUBLIC HOUSING POLICY [PDF]

open access: yes
The field of house construction in Romania is confrunting in the transition period through a real democratic system with remarkable aspects. It’s about, first of all, the human rights: that the owner of a home, which correspond to the requirements of ...
Cristian Silviu BANACU   +2 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Mutations in the Foodstuff Quality Perception of the New Consumers in Romania [PDF]

open access: yes
In the current context of the market, very complex and dynamic, we can observe the crystallization of a new generation of consumers, with a specific behavior and a particular manner of approaching the quality unlike the one of traditional consumer.
Dorin Popescu   +2 more
core  

Portacaval shunt for glycogen storage disease and hyperlipidaemia. [PDF]

open access: yes, 1977
Complete portacaval shunt was used to treat 10 patients with glycogen storage disease. A favourable effect was noted on body growth and a number of metabolic abnormalities.
Benichou, J   +3 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

VALUATION OF TARGET FIRMS ACQUIRED IN THE FOOD SECTOR DURING THE 1996-2001 WAVE [PDF]

open access: yes
The paper studies valuation ratios of food companies that were part of mergers & acquisitions (M&A) involving at least one French company during the 1996-2001 period. Results converge to value the food company 1.1 to 1.4 times its turnover.
Declerck, Francis
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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