Ferrostatin-1-loaded liposome for treatment of corneal alkali burn via targeting ferroptosis [PDF]
Bioengineering and Translational Medicine, 2022 Alkali burn is a potentially blinding corneal injury. During the progression of alkali burn‐induced injury, overwhelmed oxidative stress in the cornea triggers cell damage, including oxidative changes in cellular macromolecules and lipid peroxidation in ...
Ke Yao, Haijie Han, Qichuan Yin
exaly +3 more sources
Supersaturated Oxygen Emulsion Mitigates Hypoxia-Driven Corneal Neovascularization after Alkali Burn [PDF]
Ophthalmology SciencePurpose: Alkali burn is a vision-threatening ocular emergency with no targeted acute therapy. We previously identified tissue hypoxia as a key driver and developed a perfluorodecalin-based supersaturated oxygen emulsion (SSOE) that delivers high levels ...
Asmaa Zidan, Zhirong Lin, Jia Yin
exaly +4 more sources
Chemical (Alkali) Burn-Induced Neurotrophic Keratitis Model in New Zealand Rabbit Investigated Using Medical Clinical Readouts and In Vivo Confocal Microscopy (IVCM) [PDF]
CellsPurpose: Chemical eye injury is an acute emergency that can result in vision loss. Neurotrophic keratitis (NK) is the most common long-term manifestation of chemical injury.
Anil Tiwari, Umang Mathur, Abha Gour
exaly +4 more sources
Therapeutic potential of Jatimukuladi Varti Anjana in alkali burn-induced corneal injury and neovascularization in albino rats [PDF]
Frontiers in MedicineIntroductionCorneal transparency is maintained by its avascular nature, and disruption following injury can lead to corneal neovascularization (CNV), resulting in visual impairment.
Vishva S. Pandya +2 more
doaj +2 more sources
Expanding the Spectrum of Alkali Retinopathy: Maculopathy following Alkali Burn [PDF]
Case Reports in Ophthalmology, 2022 Ocular alkali burns are known to cause profound damage to the anterior segment, especially the cornea and conjunctiva. However, rarely, additional adjacent chorioretinal complications may ensue.
Andreas Vanclooster +2 more
doaj +2 more sources
AIP1 suppresses neovascularization by inhibiting the NOX4-induced NLRP3/NLRP6 imbalance in a murine corneal alkali burn model [PDF]
Cell Communication and Signaling, 2022 Background Apoptosis signal-regulating kinase 1-interacting protein 1 (AIP1) participates in inflammatory neovascularization induction. NADPH oxidase 4 (NOX4) produces reactive oxygen species (ROS), leading to an imbalance in nucleotide-binding ...
Qingyu Li +8 more
doaj +2 more sources
An enhanced-permeability amphiphilic nanogel loaded with sulforaphane for synergistic anti-oxidative and anti-ferroptotic therapy of corneal alkali burn [PDF]
Journal of Translational MedicineBackground Alkali-induced ocular injury is a severe blinding disease where oxidative stress and ferroptosis drive corneal neovascularization and fibrosis.
Chengcheng Yang +8 more
doaj +2 more sources
Rapamycin Mitigates Corneal Damage in a Mouse Model of Alkali Burn Injury [PDF]
BioengineeringAlkali burns to the cornea cause severe damage characterized by an intense inflammatory response driven by inflammatory cytokines, which orchestrate pathological processes, including neovascularization, fibrosis, apoptosis, abnormal cell proliferation ...
Basanta Bhujel +5 more
doaj +2 more sources
Targeting HMGB1-NFκb Axis and miR-21 by Glycyrrhizin: Role in Amelioration of Corneal Injury in a Mouse Model of Alkali Burn [PDF]
Frontiers in Pharmacology, 2022 Corneal neovascularization (CNV) is a sight-threatening condition usually associated with various inflammatory settings including chemical injury. High mobility group box 1 (HMGB1) is identified as an inflammatory alarmin in diverse tissue damage.
Peihong Wang +27 more
doaj +2 more sources
Disulfiram Ophthalmic Solution Inhibited Macrophage Infiltration by Suppressing Macrophage Pseudopodia Formation in a Rat Corneal Alkali Burn Model [PDF]
International Journal of Molecular Sciences, 2023 Etsuko Toda +2 more
exaly +2 more sources