Research on mouse model of grade II corneal alkali burn. [PDF]
International Journal of Ophthalmology, 2016 AIM: To choose appropriate concentration of sodium hydroxide (NaOH) solution to establish a stable and consistent corneal alkali burn mouse model in grade II.
Jun-Qiang Bai +2 more
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Ferrostatin-1-loaded liposome for treatment of corneal alkali burn via targeting ferroptosis [PDF]
Bioengineering and Translational Medicine, 2022 Alkali burn is a potentially blinding corneal injury. During the progression of alkali burn‐induced injury, overwhelmed oxidative stress in the cornea triggers cell damage, including oxidative changes in cellular macromolecules and lipid peroxidation in ...
Ke Yao, Haijie Han, Qichuan Yin
exaly +3 more sources
The Wound Healing Effect of Doxycycline after Corneal Alkali Burn in Rats [PDF]
Journal of Ophthalmology, 2019 Purpose. To evaluate the wound healing effect of doxycycline and its underlying mechanisms in a rat model of corneal alkali burn. Methods. Male SD rats were administered 1.0 N NaOH in the right cornea for 25 seconds and randomly divided into the ...
Qiong Yi, Wen-jin Zou
doaj +3 more sources
Transforming corneal alkali burn treatment: unveiling mechanisms and pioneering therapies from bench to bedside [PDF]
Journal of Translational MedicineCorneal alkali burns are severe ocular injuries characterized by extensive tissue damage, inflammation, oxidative stress, and neovascularization, which often lead to long-term visual impairment and corneal fibrosis.
Mengzhen Xie, Ying Jie
doaj +3 more sources
Targeting LRPPRC to improve corneal wound healing via augmenting autophagy and suppressing TGF-β/Smad signaling post-alkali burn [PDF]
Journal of Translational MedicineBackground Following corneal injury, the body initiates wound healing to maintain corneal function. Activation of the transforming growth factor beta (TGF-β) pathway promotes corneal stromal fibroblasts differentiation, leading to the excessive secretion
Bolin Chen +5 more
doaj +3 more sources
AIP1 suppresses neovascularization by inhibiting the NOX4-induced NLRP3/NLRP6 imbalance in a murine corneal alkali burn model [PDF]
Cell Communication and Signaling, 2022 Background Apoptosis signal-regulating kinase 1-interacting protein 1 (AIP1) participates in inflammatory neovascularization induction. NADPH oxidase 4 (NOX4) produces reactive oxygen species (ROS), leading to an imbalance in nucleotide-binding ...
Qingyu Li +8 more
doaj +2 more sources
LRG1 promotes corneal angiogenesis and lymphangiogenesis in a corneal alkali burn mouse model [PDF]
International Journal of Ophthalmology, 2020 "AIM: To investigate the potential effect and mechanism of leucine-rich α-2-glycoprotein-1 (LRG1) on corneal angiogenesis and lymphangiogenesis. METHODS: Corneal neovascularization and lymphatics were induced by establishing alkali burn mouse model ...
Shan Song +5 more
doaj +2 more sources
An enhanced-permeability amphiphilic nanogel loaded with sulforaphane for synergistic anti-oxidative and anti-ferroptotic therapy of corneal alkali burn [PDF]
Journal of Translational MedicineBackground Alkali-induced ocular injury is a severe blinding disease where oxidative stress and ferroptosis drive corneal neovascularization and fibrosis.
Chengcheng Yang +8 more
doaj +2 more sources
Therapeutic potential of Jatimukuladi Varti Anjana in alkali burn-induced corneal injury and neovascularization in albino rats [PDF]
Frontiers in MedicineIntroductionCorneal transparency is maintained by its avascular nature, and disruption following injury can lead to corneal neovascularization (CNV), resulting in visual impairment.
Vishva S. Pandya +2 more
doaj +2 more sources
CXCR3 deletion aggravates corneal neovascularization in a corneal alkali-burn model [PDF]
Experimental Eye Research, 2022 Shengguo Li, Shuizhen Shi
exaly +2 more sources