Disulfiram Ophthalmic Solution Inhibited Macrophage Infiltration by Suppressing Macrophage Pseudopodia Formation in a Rat Corneal Alkali Burn Model [PDF]
International Journal of Molecular Sciences, 2023 FROUNT is an intracellular protein that promotes pseudopodia formation by binding to the chemokine receptors CCR2 and CCR5 on macrophages. Recently, disulfiram (DSF), a drug treatment for alcoholism, was found to have FROUNT inhibitory activity.
Etsuko Toda +2 more
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Effects of nicotine on corneal wound healing following acute alkali burn.
PLoS ONE, 2017 Epidemiological studies have indicated that smoking is a pivotal risk factor for the progression of several chronic diseases. Nicotine, the addictive component of cigarettes, has powerful pathophysiological properties in the body. Although the effects of
Jong Won Kim +2 more
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The inhibitory effect of doxycycline on oxidative stress injury after corneal alkali burn in rats [PDF]
Guangxi Yike Daxue xuebaoObjective To observe the inhibitory effect of doxycycline (Doxy) on oxidative stress injury after corneal alkali burn in rats. Methods A total of 204 healthy SD rats were randomly divided into normal group, model group and Doxy group, with 68 rats in ...
WANG Lizhi, ZOU Wenjin
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Inhibitory effect of polysulfated heparin endostatin onalkali burn induced corneal neovascularization in rabbits [PDF]
International Journal of Ophthalmology, 2015 AIM: To investigate anti-angiogenic effects of polysulfated heparin endostatin (PSH-ES) on alkali burn induced corneal neovascularization (NV) in rabbits.
Zhao-Na Li +7 more
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Minocycline inhibits alkali burn-induced corneal neovascularization in mice. [PDF]
PLoS ONE, 2012 The purpose of this study was to investigate the effects of minocycline on alkali burn-induced corneal neovascularization (CNV). A total of 105 mice treated with alkali burns were randomly divided into three groups to receive intraperitoneal injections ...
Ou Xiao +5 more
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Supersaturated Oxygen Emulsion Mitigates Hypoxia-Driven Corneal Neovascularization after Alkali Burn
Ophthalmology SciencePurpose: Alkali burn is a vision-threatening ocular emergency with no targeted acute therapy. We previously identified tissue hypoxia as a key driver and developed a perfluorodecalin-based supersaturated oxygen emulsion (SSOE) that delivers high levels ...
Asmaa A. Zidan, MD +5 more
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Drug Design, Development and Therapy, 2018 Ling Chen,* Jing Zhong,* Saiqun Li, Weihua Li, Bowen Wang, Yuqing Deng, Jin Yuan State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China *These authors contributed equally to this work ...
Chen L +6 more
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Role of mesenchymal stem cells on cornea wound healing induced by acute alkali burn. [PDF]
PLoS ONE, 2012 The aim of this study was to investigate the effects of subconjunctivally administered mesenchymal stem cells (MSCs) on corneal wound healing in the acute stage of an alkali burn.
Lin Yao +8 more
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Ophthalmic Combination of SurR9-C84A and Trichostatin-A Targeting Molecular Pathogenesis of Alkali Burn [PDF]
Frontiers in Pharmacology, 2016 Background: Alkali burn is a frequently occurring ocular injury that resembles ocular inflammation caused by eye allergies, infection, and refractive surgeries.Methods: We investigated the synergistic regenerative potential of dominant negative survivin ...
Kislay Roy +3 more
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Effect of Collagen Cross-Linking on Alkali Burn-Induced Corneal Neovascularization in Rabbits
Journal of Ophthalmology, 2018 Objective. This study aims at investigating the effects and molecular mechanism of riboflavin-ultraviolet-A-induced cross-linking (corneal collagen cross-linking, CXL) on corneal neovascularization (CNV) in a rabbit alkali burn model. Methods. A total of
Xiaoying Xu, Taixiang Liu, Haixiang Li
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