Results 21 to 30 of about 322,268 (148)

Targeting lactylation in a novel metabolic-epigenetic-inflammatory axis mitigates inflammation and promotes healing following corneal injury [PDF]

Journal of Translational Medicine
Purpose To investigate the potential roles of histone lactylation, N6-methyladenosine (m6A) modification, and the Janus kinase-signal transducer and activator of transcription 3 (JAK-STAT3) pathway in regulating the wound healing following corneal alkali
Yi Guan, Jinghua Liu, Ying liu, Yarong Yan, Zhengyu Chao, Xinlin Yan, Jiaqi Lin, Yulei Huang, Jiahao Zhu, Shumei Yang, Li Jiang, Ruifang Han, Xuan Li   +12 more
doaj   +2 more sources

Inhibition of PRMT5 reduces angiogenesis in a corneal neovascularization model by blocking NLRP3-mediated pyroptosis [PDF]

Clinical Epigenetics
Protein arginine methyltransferase 5 (PRMT5) is a histone methyltransferase crucial for cell proliferation, differentiation, and inflammation.
Jiewen Mao, Siyu Ding, Qian Deng, Zixian Yang, Xiaoshuo Shi, Yingli Wang, Wanju Yang, Yanning Yang, Shanshan Wan   +8 more
doaj   +2 more sources

Topical Ophthalmic Formulation of Trichostatin A and SurR9-C84A for Quick Recovery Post-alkali Burn of Corneal Haze [PDF]

Frontiers in Pharmacology, 2017
Alkali burn injury is a true ocular emergency of the conjunctiva and cornea that requires immediate precision. Lack of an immediate therapy can lead to a substantial damage in the ocular surface and anterior segment further causing visual impairment and ...
Kislay Roy, Prasad Neerati, Chun Hei Antonio Cheung, Rupinder K. Kanwar, Rajat Sandhir, Jagat R. Kanwar   +5 more
doaj   +3 more sources

S1P, Generated by Sphingosine Kinase 1, Negatively Affects Corneal Wound Healing Process by Activating TGF-β/Smad Pathway

Analytical Cellular Pathology
Abnormal healing of corneal injury can lead to corneal opacity, a leading cause of blindness. This process is extremely complex and involves precise interactions of multiple signaling pathways.
Sandip K. Basu, Sarah E. Nicholas, Bradley P. Hambly, Nataliya Lenchik, Richard C. Grambergs, T. J. Hollingsworth, Amanda Prislovsky, Dimitrios Karamichos, Nawajes Mandal   +8 more
doaj   +2 more sources

Topical Pirfenidone-Loaded Liposomes Ophthalmic Formulation Reduces Haze Development after Corneal Alkali Burn in Mice. [PDF]

Pharmaceutics, 2022
Corneal chemical burns (CCBs) frequently result in corneal fibrosis or haze, an opacity of the cornea that obstructs vision and induces corneal blindness. Diverse strategies have been employed to prevent or reduce CCB-related corneal haze. In this study,
Diaz-Palomera CD, Vidal-Paredes IA, Navarro-Partida J, Cid-Hernandez M, Rosales-Rivera LC, De la Rosa-Bibiano R, Monroy-Ramirez HC, Monroy-Ramirez HC, Santos A, Armendariz-Borunda J.   +9 more
europepmc   +2 more sources

A histological and immunohistochemical study of the effect of platelet- rich plasma on a corneal alkali burn in adult male albino rat [PDF]

The Egyptian Journal of Histology, 2019
Background: Ocular chemical injuries are an emergency that needs immediate and intensive evaluation and treatment. Platelet- rich plasma (PRP) has become a common treatment in the field of ophthalmological surgery.Aim of the study: to evaluate and ...
Heba Sharaf eldin, Marwa Ibrahim, Noha Elswaidy   +2 more
doaj   +1 more source

Comparative Histological Study on the Effect of Early and Late Administration of Adipose Derived Stem Cells on Corneal Alkali Burn in Adult Male Albino Rats [PDF]

The Egyptian Journal of Histology, 2019
Introduction: Corneal alkali burns cause corneal infection, ulceration, perforation, neo-vascularization (NV) and opacification resulting in permanent visual impairment.
Sahar Nasser, Mary Morcos, Maha Gazia, Marwa Yousry, Amira Osman   +4 more
doaj   +1 more source

Effects of Aberrant Pax6 Gene Dosage on Mouse Corneal Pathophysiology and Corneal Epithelial Homeostasis [PDF]

, 2011
Background: Altered dosage of the transcription factor PAX6 causes multiple human eye pathophysiologies. PAX6(+/-) heterozygotes suffer from aniridia and aniridia-related keratopathy (ARK), a corneal deterioration that probably involves a limbal ...
Fullwood, Nigel J., Martin, Francis L., Collinson, J. Martin, Richard L Mort, Morley, Steven D., Morley Steven D., West John D., Bentley, Adam J., Adam J Bentley, Mort, Richard L, Collinson J. Martin, Panagiotis Douvaras, Collinson, J Martin, J Martin Collinson, Bentley Adam J., Mort Richard L., Martin, Francis L, Bentley, Adam J, Morley, Steven D, Martin Francis L., Douvaras, Panagiotis, Steven D Morley, Robert E Hill, Mort, Richard L., West, John D., Hill, Robert E, Fullwood, Nigel J, Nigel J Fullwood, Douvaras Panagiotis, Fullwood Nigel J., Francis L Martin, Hill Robert E., Hill, Robert E., West, John D, John D West   +34 more
core   +5 more sources

Effects of Selective Peroxisome Proliferator Activated Receptor Agonists on Corneal Epithelial Wound Healing

Pharmaceuticals, 2021
The effects of each subtype-selective peroxisome proliferator activated receptor (PPAR) agonist (α, β/δ, γ) on corneal epithelial wound healing were investigated using a rat corneal alkali burn model.
Yutaro Tobita, Takeshi Arima, Yuji Nakano, Masaaki Uchiyama, Akira Shimizu, Hiroshi Takahashi   +5 more
doaj   +1 more source

Comparative Histological and Immunohistochemical Study on the Effect of Platelet-Rich Plasma, Adipose Tissue Derived Mesenchymal Stem Cells, and Mesenchymal Stem Cells Derived Exosomes in Experimentally Induced Corneal Alkali Burn in Albino Rats [PDF]

The Egyptian Journal of Histology
Background and Objectives: Alkali damage to the cornea can be catastrophic and results in lifelong pain and visual loss. Investigation and comparison of the potential therapeutic effects of platelet-rich plasma (PRP), adipose tissue derived mesenchymal ...
Sahar Nasr, Amal Fares, Eman Al-Sayed, Asmaa El-Shafei   +3 more
doaj   +1 more source