Results 41 to 50 of about 322,268 (148)

Liposome–trimethyl chitosan nanoparticles codeliver insulin and siVEGF to treat corneal alkali burns by inhibiting ferroptosis

Bioengineering & Translational Medicine, 2023
Alkali burns are potentially blinding corneal injuries. Due to the lack of available effective therapies, the prognosis is poor. Thus, effective treatment methods for corneal alkali burns are urgently needed.
Xiaojing Xiong, Huiting Jiang, Yukun Liao, Yangrui Du, Yu Zhang, Zhigang Wang, Minming Zheng, Zhiyu Du   +7 more
doaj   +1 more source

Platelet Rich Plasma versus Ascorbic Acid as a Possible Treatment for Alkali-Induced Corneal Burn in Adult Male Albino Rats [Histological and Ultrastructural Study]

The Egyptian Journal of Histology
Background: Chemical ocular burns are the main ophthalmic emergencies which need immediate examination and intensive care. Alkali corneal burn is considered a defect in the corneal epithelium, in addition to stromal inflammation, loss of corneal stroma ...
Sahar Gouda, Horeya Korayem, Sahar Khalil, Ahmed Abdelghany, Aya Mostafa   +4 more
doaj   +1 more source

Особливості реорганізації структур рогівки кролів з її хімічним опіком на тлі мерказоліл-індукованого гіпотирозу = Peculiarities of reorganization of the rabbits’ corneal structure with its chemical burn at the background of merkazolil-induced hypothyroidism [PDF]

, 2014
Savchuk Z. L., Klishch I. M., Herasymiuk I. Ye. Особливості реорганізації структур рогівки кролів з її хімічним опіком на тлі мерказоліл-індукованого гіпотирозу = Peculiarities of reorganization of the rabbits’ corneal structure with its chemical burn at
Savchuk, Z. L., Herasymiuk, I. Ye., Klishch, I. M.   +2 more
core   +1 more source

Lipoxin A4 (LXA4) Reduces Alkali-Induced Corneal Inflammation and Neovascularization and Upregulates a Repair Transcriptome

Biomolecules, 2023
Purpose: To investigate the anti-inflammatory and anti-angiogenic effects of the bioactive lipid mediator LXA4 on a rat model of severe corneal alkali injury.
Jiucheng He, Thang L. Pham, Azucena H. Kakazu, Abhilash Ponnath, Khanh V. Do, Haydee E. P. Bazan   +5 more
doaj   +1 more source

Pirfenidone nanoparticles improve corneal wound healing and prevent scarring following alkali burn. [PDF]

, 2013
To evaluate the effects of pirfenidone nanoparticles on corneal re-epithelialization and scarring, major clinical challenges after alkali burn.Effect of pirfenidone on collagen I and α-smooth muscle actin (α-SMA) synthesis by TGFβ induced primary corneal
Ruchit Trivedi, Sushovan Chowdhury, Rajdeep Guha, Sarbani Hazra, Uday B Kompella, Aditya Konar   +5 more
core   +1 more source

Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs

Communications Biology, 2021
Simpson, McTiernan et al. develop fully synthetic corneal implants. The resulting CLP-PEG-MPC implants show reduced corneal swelling, haze, and neovascularization compared to CLP-PEG only implants when grafted into a mini-pig cornea alkali burn model of ...
Fiona C. Simpson, Christopher D. McTiernan, Mohammad Mirazul Islam, Oleksiy Buznyk, Philip N. Lewis, Keith M. Meek, Michel Haagdorens, Cindy Audiger, Sylvie Lesage, François-Xavier Gueriot, Isabelle Brunette, Marie-Claude Robert, David Olsen, Laura Koivusalo, Aneta Liszka, Per Fagerholm, Miguel Gonzalez-Andrades, May Griffith   +17 more
doaj   +1 more source

Accidents in the Chemical Industry: A Scoping Review Focused on Causal Factors

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Although occupational safety in the chemical industry is an area of ongoing research worldwide, chemical incidents continue to occur, indicating the need to review the causes, assist in safety management, and identify problems in the quality of reporting. Methods A systematic search of studies published in English between January 1,
Željka Babić, Emin Veledar, Zrinka Franić, Franka Šakić, Mojca Dobaja Borak, Lucija Šarc, Jelena Macan, Miran Brvar   +7 more
wiley   +1 more source

Reconstruction of deep and perforating corneal defects in dogs—A review (Part II/III): Biomaterials and keratoprosthesis

Veterinary Ophthalmology, Volume 28, Issue 2, Page 532-542, March 2025.
Abstract The surgical reconstruction of severe corneal ulcers is a common and crucial component of the clinical practice of veterinary ophthalmology. Numerous surgical techniques are used in dogs for corneal reconstruction, and these techniques may be categorized by the material used to repair the corneal lesion.
Eric C. Ledbetter, Rick F. Sanchez, Marta Leiva Repiso   +2 more
wiley   +1 more source

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Multifunctional Hydrogels: Rational Design and Application in Regenerative Medicine

MedComm, Volume 7, Issue 10, October 2026.
Multifunctional hydrogels represent a paradigm shift in regenerative medicine, integrating rational material design with bioactive functionality to address complex tissue repair challenges. This review systematically examines the molecular engineering, structure–function relationships, and translational landscape of advanced hydrogel systems, spanning ...
Linyang Song, Epiphane K. Silli, Yazhen Xu, Huixia Lv, Ruoxian Song   +4 more
wiley   +1 more source