Results 31 to 40 of about 322,268 (148)

Pathogenesis of Alkali Injury-Induced Limbal Stem Cell Deficiency: A Literature Survey of Animal Models

Cells, 2023
Limbal stem cell deficiency (LSCD) is a debilitating ocular surface disease that eventuates from a depleted or dysfunctional limbal epithelial stem cell (LESC) pool, resulting in corneal epithelial failure and blindness.
Lina Sprogyte, Mijeong Park, Nick Di Girolamo   +2 more
doaj   +1 more source

Effect of nintedanib thermo-sensitive hydrogel on neovascularization in alkali burn rat model [PDF]

International Journal of Ophthalmology, 2020
AIM: To investigate the effects of nintedanib thermo-sensitive hydrogel (NTH) on neovascularization and related markers in corneal alkali burns of Wistar rats.
Yan Gong, Guo-Hai Wu, Ling-Yi Zhang, Zhe Zhang, Yan-Hong Liao, Xiao-Tian Liu   +5 more
doaj   +1 more source

Inhibition of NUCKS Facilitates Corneal Recovery Following Alkali Burn [PDF]

, 2017
Corneal wound healing involves a complex cascade of cytokine-controlled cellular events, including inflammatory and angiogenesis responses that are regulated by transcriptional chromatin remodeling.
Lian, Q, Wong, DSH, Li, Qing, Wong, YHI, Qiu, B, Jiang, Dan, Chanda, S, Tse, H.-F, Qin, P, Yu, Zhendong, Qin, Peng, Poon, M.-W, Tergaonkar, V, Tse, Hung-Fat, Jiang, D, Poon, MW, Zhang, Y, Wong, D.S.H, Poon, Ming-Wai, Qiu, Beiying, Lian, Qizhou, Tergaonkar, Vinay, Wong, Ian Y., Tse, HF, Yu, Z, Wong, David S. H., Chanda, Sumit, Zhang, Yuelin, Li, Q, Wong, I.Y   +29 more
core   +1 more source

Zeb1 regulation of wound-healing-induced inflammation in alkali-damaged corneas

iScience, 2022
Summary: The cornea is an avascular tissue for vision clarity. Alkali burn could cause severe traumatic damage on the cornea with inflammation and neovascularization (NV), leading to vision reduction and blindness.
Wei Liang, Yingnan Zhang, Liang Zhou, Xiaoqin Lu, Margaret E. Finn, Wei Wang, Hui Shao, Douglas C. Dean, Lijun Zhang, Yongqing Liu   +9 more
doaj   +1 more source

Alkali burn induced corneal spontaneous pain and activated neuropathic pain matrix in the central nerve system in mice [PDF]

, 2017
Purpose: To explore whether alkali burn causes corneal neuropathic pain and activates neuropathic pain matrix in the central nerve system in mice. Methods: A corneal alkali burn mouse model (grade II) was used.
Yan Xiang, Hongbin Xiang, Anne Manyande, Hui Yang, Manyande, Anne, Xuebi Tian, Xiang, Yan, Xiang, Hongbin, Ping Wang, Tian, Xuebi, Wang, Ping, Yang, Hui, Tian, Yu-Ke, Wenchang Zhou, Feng Gao, Gao, Feng, Zhou, Wenchang, Yuke Tian   +17 more
core   +1 more source

Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn. [PDF]

Int J Mol Sci, 2017
Epithelial cells are involved in the regulation of innate and adaptive immunity in response to different stresses. The purpose of this study was to investigate if alkali-injured corneal epithelia activate innate immunity through the nucleotide-binding ...
Bian F, Xiao Y, Zaheer M, Volpe EA, Pflugfelder SC, Li DQ, de Paiva CS.   +6 more
europepmc   +2 more sources

The Potential Therapeutic Effect of Liposomal Ozonated Oil on Experimentally Induced Corneal Alkali Burns in Adult Male Albino Rats (Histological and Immunohistochemical Study) [PDF]

The Egyptian Journal of Histology
Introduction: Corneal alkali burns are true ophthalmic emergency cases that need immediate medical intervention to reduce the severe complications and restore patients' vision.
Dalia El-ghazouly, Rania Yassien, Eman El_Roghy   +2 more
doaj   +1 more source

Pro-inflammatory role of NLRP3 inflammasome in experimental sterile corneal inflammation

Scientific Reports, 2019
We evaluated the role of NLR family pyrin domain containing 3 (NLRP3) inflammasome in sterile corneal inflammation caused by lipopolysaccharide (LPS) or alkali burns in C57BL6 mice or NLRP3 KO (Nlrp3 −/− ) mice.
Hiroaki Shimizu, Tohru Sakimoto, Satoru Yamagami   +2 more
doaj   +1 more source

Therapeutic effects of topical netrin-4 in a corneal acute inflammatory model [PDF]

International Journal of Ophthalmology, 2015
AIM: To evaluate the therapeutic effect of netrin-4 on the early acute phase of inflammation in the alkali-burned eye. METHODS: Eye drops containing netrin-4 or phosphate buffered saline (PBS) were administered to a alkali-burn-induced corneal acute ...
Yun Han, Yi Shao, Ting-Ting Liu, Sang-Ming Li, Wei Li, Zu-Guo Liu   +5 more
doaj   +1 more source

Comparative Analysis of Matrix-Regenerating Agent and Corneal Cross-Linking in an Experimental Alkali Burn Rabbit Model

, 2022
Purpose This study aimed to investigate the clinical and histopathological effects of corneal cross-linking (CXL) and matrix-regenerating agent (RGTA) treatments after corneal alkali burn.
Furat Rencber, Selenay Hümeyra, Pirhan, Dilara, Yuksel, NURŞEN, Yardimoglu Yilmaz, Melda, Bicaklioglu, Gozde, Kesim, ENES, Yazir, Yusufhan   +6 more
core   +1 more source