Results 51 to 60 of about 322,268 (148)

Polysaccharide hydrogel combined with mesenchymal stem cells promotes the healing of corneal alkali burn in rats. [PDF]

, 2015
Corneal chemical burns are common ophthalmic injuries that may result in permanent visual impairment. Although significant advances have been achieved on the treatment of such cases, the structural and functional restoration of a chemical burn-injured ...
Xun Liu, Min Yu (120607), Xuan Cui (706042), Xun Liu (285130), Chunbo Yang, Xuan Cui, Yifeng Ke, Xiaorong Li (66719), Chunbo Yang (706043), Yifeng Ke (706040), Xiaorong Li, Min Yu, Yixiang Wu (706041), Yixiang Wu   +13 more
core   +1 more source

Stem Cell‐Based Approaches for Neurotrophic Keratopathy: From Ocular Surface to Neuro‐Ophthalmology

Sensory Neuroscience, Volume 2, Issue 3, September 2026.
ABSTRACT Neurotrophic keratopathy is an uncommon, but potentially sight‐threatening, corneal disorder that results from impaired trigeminal sensory innervation. The loss of corneal sensation disrupts epithelial stability, weakens wound healing, and may lead to persistent epithelial defects, stromal ulceration, and, in the most advanced cases, corneal ...
Matteo Capobianco, Marco Zeppieri
wiley   +1 more source

Data from: Effects of nicotine on corneal wound healing following acute alkali burn

, 2017
Epidemiological studies have indicated that smoking is a pivotal risk factor for the progression of several chronic diseases. Nicotine, the addictive component of cigarettes, has powerful pathophysiological properties in the body. Although the effects of
Lim, Chae Woong, Kim, Bumseok, Kim, Jong Won   +2 more
core   +1 more source

3D Culture Reverses Limbal Niche Cell Replicative Aging via FOSL1 Upregulation

Aging Cell, Volume 25, Issue 9, September 2026.
3D culture reverses LNC replicative aging via FOSL1 upregulation, enhancing mitochondrial function and alleviating oxidative stress. ABSTRACT Limbal niche cells (LNCs) serve as essential regulators of limbal microenvironmental homeostasis and corneal epithelial wound repair, representing a promising therapeutic resource for limbal stem cell deficiency (
Xuying Wang, Shen Li, Zibin Liu, Xinghan Guo, Jiachao Shen, Tianyu Zhou, Shuying Liao, Xiaoyu Huang, Wei Wang, Lingjuan Xu, Xinjie Zang, Guigang Li   +11 more
wiley   +1 more source

Comparison of therapeutic effects between topical 8-oxo-2′-deoxyguanosine and corticosteroid in ocular alkali burn model

Scientific Reports, 2021
We compared the therapeutic effects of topical 8-oxo-2′-deoxyguanosine (8-oxo-dG) and corticosteroid in a murine ocular alkali burn model. (n = 128) The corneal alkali burn model was established by applying 0.1 N sodium hydroxide (NaOH), followed by ...
Dong Hyun Kim, Sang-Taek Im, Jin Young Yoon, Seunghoon Kim, Mee Kum Kim, Myung-Hee Chung, Chul-Kyu Park   +6 more
doaj   +1 more source

Microenvironment‐Responsive Drug Delivery Systems for Ocular Surface Diseases: Mechanisms, Applications, and Translational Challenges

Small Science, Volume 6, Issue 8, August 2026.
Microenvironment‐responsive drug delivery systems overcome ocular physiological barriers by responding to temperature, pH, ions, reactive oxygen species, and enzymes. This review bridges material design, performance evaluation, and clinical translation, offering actionable insights for treating dry eye disease, infectious keratitis, and corneal ...
Jiamin Liu, Liangbo Chen, Yao Fu, Siyi Zhang   +3 more
wiley   +1 more source

Effect of Nitric Oxide on Human Corneal Epithelial Cell Viability and Corneal Wound Healing

Scientific Reports, 2017
Although the wound healing effects of nitric oxide (NO) are known, the mechanism by which NO modulates corneal wound healing remains unclear. In this study, we investigated the effect of exogenous NO donor (NaNO2) on corneal wound healing.
Joo-Hee Park, Ja-Yeon Kim, Dong Ju Kim, Martha Kim, Minwook Chang, Roy S. Chuck, Choul Yong Park   +6 more
doaj   +1 more source

Efficacy of the nucleotide-binding oligomerzation domain 1 inhibitor Nodinhibit-1 on corneal alkali burns in rats [PDF]

International Journal of Ophthalmology, 2015
AIM:To evaluate the therapeutic effect of Nodinhibit-1 on alkali-burn-induced corneal neovascularization (CNV) and inflammation.The nucleotide-binding oligomerzation domain 1 (NOD1) is a potent angiogenic gene.METHODS:The alkali-burned rat corneas (32 ...
Xu Huang, Yun Han, Yi Shao, Jing-Lin Yi
doaj   +1 more source

A moderate dosage of prostaglandin E2-mediated annexin A1 upregulation promotes alkali-burned corneal repair

iScience, 2023
Summary: Corneal alkali burn remains a clinical challenge in ocular emergency, necessitating the development of effective therapeutic drugs. Here, we observed the arachidonic acid metabolic disorders of corneas induced by alkali burns and aimed to ...
Hongling Liu, Xue Zhang, Qiang Tan, Lingling Ge, Jia Lu, Chunge Ren, Baishijiao Bian, Yijian Li, Yong Liu   +8 more
doaj   +1 more source

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source