Pro-inflammatory role of NLRP3 inflammasome in experimental sterile corneal inflammation
Scientific Reports, 2019 We evaluated the role of NLR family pyrin domain containing 3 (NLRP3) inflammasome in sterile corneal inflammation caused by lipopolysaccharide (LPS) or alkali burns in C57BL6 mice or NLRP3 KO (Nlrp3 −/− ) mice.
Hiroaki Shimizu +2 more
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Effects of nicotine on corneal wound healing following acute alkali burn.
PLoS ONE, 2017 Epidemiological studies have indicated that smoking is a pivotal risk factor for the progression of several chronic diseases. Nicotine, the addictive component of cigarettes, has powerful pathophysiological properties in the body. Although the effects of
Jong Won Kim +2 more
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The Potential Therapeutic Effect of Liposomal Ozonated Oil on Experimentally Induced Corneal Alkali Burns in Adult Male Albino Rats (Histological and Immunohistochemical Study) [PDF]
The Egyptian Journal of HistologyIntroduction: Corneal alkali burns are true ophthalmic emergency cases that need immediate medical intervention to reduce the severe complications and restore patients' vision.
Dalia El-ghazouly +2 more
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Inhibitory effect of polysulfated heparin endostatin onalkali burn induced corneal neovascularization in rabbits [PDF]
International Journal of Ophthalmology, 2015 AIM: To investigate anti-angiogenic effects of polysulfated heparin endostatin (PSH-ES) on alkali burn induced corneal neovascularization (NV) in rabbits.
Zhao-Na Li +7 more
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Efficacy of the nucleotide-binding oligomerzation domain 1 inhibitor Nodinhibit-1 on corneal alkali burns in rats [PDF]
International Journal of Ophthalmology, 2015 AIM:To evaluate the therapeutic effect of Nodinhibit-1 on alkali-burn-induced corneal neovascularization (CNV) and inflammation.The nucleotide-binding oligomerzation domain 1 (NOD1) is a potent angiogenic gene.METHODS:The alkali-burned rat corneas (32 ...
Xu Huang, Yun Han, Yi Shao, Jing-Lin Yi
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Scientific Reports, 2021 We compared the therapeutic effects of topical 8-oxo-2′-deoxyguanosine (8-oxo-dG) and corticosteroid in a murine ocular alkali burn model. (n = 128) The corneal alkali burn model was established by applying 0.1 N sodium hydroxide (NaOH), followed by ...
Dong Hyun Kim +6 more
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Role of mesenchymal stem cells on cornea wound healing induced by acute alkali burn. [PDF]
PLoS ONE, 2012 The aim of this study was to investigate the effects of subconjunctivally administered mesenchymal stem cells (MSCs) on corneal wound healing in the acute stage of an alkali burn.
Lin Yao +8 more
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Zeb1 regulation of wound-healing-induced inflammation in alkali-damaged corneas
iScience, 2022 Summary: The cornea is an avascular tissue for vision clarity. Alkali burn could cause severe traumatic damage on the cornea with inflammation and neovascularization (NV), leading to vision reduction and blindness.
Wei Liang +9 more
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Saintika Medika, 2017 Purpose : to evaluate the effects of Methanolic extract of Cowpea (Vigna unguiculata) administration on vascular endothelial growth factor (VEGF) expression in rats with corneal-alkali induced inflammation.
Yuliono Trika Nur Hasan +2 more
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The Egyptian Journal of HistologyBackground: Chemical ocular burns are the main ophthalmic emergencies which need immediate examination and intensive care. Alkali corneal burn is considered a defect in the corneal epithelium, in addition to stromal inflammation, loss of corneal stroma ...
Sahar Gouda +4 more
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