Eco-friendly RP-HPLC method for determination of diazepam in coated tablet
Macedonian Journal of Chemistry and Chemical Engineering, 2023 A new eco-friendly RP-HPLC method for determining diazepam in coated tablets was developed and validated. The separation was achieved on a Lichrosper® 100 RP-18 (250 mm × 4 mm, 5 µm particle size) using the isocratic elution mode with a mobile phase ...
Marija Tomić +6 more
doaj +1 more source
Macedonian Journal of Chemistry and Chemical Engineering, 2021 Fast and simple closed-vessel microwave-assisted digestion procedure was developed for decomposition of three pharmaceutical dosage forms of ibuprofen such as tablets, suspension and gel, prior to elemental impurity analysis by one robust and precise ...
Katerina Jancevska +4 more
doaj +1 more source
Providing clinical evidence under the MDR 2017/745: New challenges for manufacturers in medical device industry [PDF]
Arhiv za farmaciju, 2019 Providing necessary clinical evidence throughout the systems for Clinical Evaluation and Post-Market Surveillance in accordance with new MDR 2017/745 requirements imposes new challenges for manufacturers in medical device industry.
Ivanovska Elena +5 more
doaj +1 more source
Macedonian Journal of Chemistry and Chemical Engineering, 2022 This research highlights the specificity of the new stability-indicating method developed to evaluate the impurity profile of Atorvastatin film-coated tablets. The proposed method has the ability to capture any possible changes that may occur during the
Elena Trajchova Kovachovska +6 more
doaj +1 more source
Investigation of the influence of critical process parameters in roller compaction process on physical properties of granules and tablets using design of experiments [PDF]
Arhiv za farmaciju, 2020 Different granulation methods are used in the pharmaceutical industry, mainly divided as wet or dry granulation. Although roller compaction is a widely used dry granulation process, the evaluation of critical process parameters has proven challenging ...
Atanaskova Elizabeta +2 more
doaj +1 more source
Novel pyrrolizidine alkaloid [PDF]
, 1991 The present invention involves a purified bioactive compound of the formula: ##STR1## wherein at least one of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are H or an acyl having less than about five carbon atoms.
Elbein, Alan D., Tropea, Joseph E.
core +1 more source
Complaints management in the pharmaceutical industry: A Case Study [PDF]
Makedonsko Farmacevtski BiltenEffective complaints management in the pharmaceutical industry is one of the cornerstones for ensuring product quality, regulatory compliance, and customer safety and satisfaction.
Marija Stojanovska +4 more
doaj +1 more source
An integrated targeted and untargeted approach for the analysis of ergot alkaloids in cereals using UHPLC - hybrid quadrupole time-of-flight mass spectrometry [PDF]
, 2015 An ultra-high performance liquid chromatography hybrid quadrupole time of flight (Q-TOF) mass spectrometry (MS) method is described for the simultaneous quantitative determination of common ergot alkaloids and the screening, detection and identification ...
Arroyo Manzanares, Natalia +5 more
core +2 more sources
Workflow for investigation of Out of Specification results in physico-chemical laboratory in Alkaloid [PDF]
Makedonsko Farmacevtski BiltenThe efficient and accurate investigation of Out of Specification (OOS) results is crucial in maintaining the reliability and quality of products in a physico-chemical laboratory.
Andrea Alagjozovska +8 more
doaj +1 more source
Involvement of the leaf-specific multidrug and toxic compound extrusion (MATE) transporter Nt-JAT2 in vacuolar sequestration of nicotine in Nicotiana tabacum [PDF]
, 2014 Alkaloids play a key role in higher plant defense against pathogens and herbivores. Following its biosynthesis in root tissues, nicotine, the major alkaloid of Nicotiana species, is translocated via xylem transport toward the accumulation sites, leaf ...
Goossens, Alain +11 more
core +4 more sources